Results 71 to 80 of about 231,424 (276)

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

A novel method to design biomimetic, 3D printable stochastic scaffolds with controlled porosity for bone tissue engineering

Materials & Design, 2022
Periodic cellular materials such as body-centered cubic, face-centered cubic, and triply periodic minimal surfaces, have been used to construct scaffolds for bone tissue engineering. Their use is suboptimal for reasons like stress concentration at nodes,
Susheem Kanwar, Oraib Al-Ketan, Sanjairaj Vijayavenkataraman   +2 more
doaj  

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Structural relaxation in amorphous materials under cyclic tension-compression loading

, 2019
The process of structural relaxation in disordered solids subjected to repeated tension-compression loading is studied using molecular dynamics simulations.
Jana, Pritam Kumar, Priezjev, Nikolai V.
core   +1 more source

Visco-Node-Pore Sensing: A Microfluidic Rheology Platform to Characterize Viscoelastic Properties of Epithelial Cells. [PDF]

, 2019
Viscoelastic properties of cells provide valuable information regarding biological or clinically relevant cellular characteristics. Here, we introduce a new, electronic-based, microfluidic platform-visco-node-pore sensing (visco-NPS)-which quantifies ...
Kim, Junghyun, Kim, Youngbin, Li, Brian, Scheideler, Olivia, Sohn, Lydia   +4 more
core   +1 more source

Modulate stress distribution with bio-inspired irregular architected materials towards optimal tissue support

Nature Communications
Natural materials typically exhibit irregular and non-periodic architectures, endowing them with compelling functionalities such as body protection, camouflage, and mechanical stress modulation.
Yingqi Jia, Ke Liu, Xiaojia Shelly Zhang
doaj   +1 more source

Mechanical behaviour of additively manufactured elastomeric pre-buckled honeycombs under quasi-static and impact loading

Materials & Design, 2022
Selective laser sintering has been used to manufacture different structural variations of a pre-buckled circular honeycomb. The mechanical behaviour of these structures has been examined under both quasi-static and dynamic impact loading.
Rhosslyn Adams, Scott Townsend, Shwe Soe, Peter Theobald   +3 more
doaj  

Elastic effects on relaxation volume tensor calculations

, 2008
Relaxation volume tensors quantify the effect of stress on diffusion of crystal defects. Continuum linear elasticity predicts that calculations of these parameters using periodic boundary conditions do not suffer from systematic deviations due to elastic
B. Puchala, C.-H. Ge, K. Garikipati, M. L. Falk, P. A. Packan, R. E. Miller, V. Gavini, W. Windl   +7 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source