Results 61 to 70 of about 5,468,047 (208)

M2 macrophage-derived exosomes enable osteogenic differentiation and inhibit inflammation in human periodontal ligament stem cells through promotion of CXCL12 expression

BMC Oral Health
Periodontitis is a dental disease characterized by inflammation of periodontal tissues and loss of the periodontal ligaments and alveolar bone. Exosomes are a class of extracellular vesicles that are involved in a variety of diseases by releasing active ...
Jie Gao, Zhi-Gang Wu
semanticscholar   +1 more source

Single cell RNA sequencing analysis of human dental pulp stem cells and human periodontal ligament stem cells.

Journal of Endodontics, 2021
INTRODUCTION Many studies have investigated the transcriptome profiles of dental stem cells for regenerative medicine. However, such studies use bulk RNA and do not consider cell-level heterogeneity.
Sukjoon Lee, Dongzi Chen, Munsu Park, Sunil Kim, Y. Choi, S. Moon, D. Shin, J. H. Lee, Kim Euiseong   +8 more
semanticscholar   +1 more source

Autologous periodontal stem cell assistance in periodontal regeneration technique (SAI-PRT) in the treatment of periodontal intrabony defects: A case report with one-year follow-up [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects, 2017
Numerous animal and human studies have provided evidence supporting the belief that periodontal ligament stem cells (PDLSCs) can be harnessed for regeneration of periodontal tissues.
Vandana KL, Haneet Ryana, Priyanka Jairaj Dalvi   +2 more
doaj   +1 more source

Antibacterial periodontal ligament stem cells enhance periodontal regeneration and regulate the oral microbiome

Stem cell research & therapeutics
The transplantation of periodontal ligament stem cells (PDLSCs) has been shown to enhance periodontal regeneration in animal models and clinical trials.
Jiayi You, Qian Zhang, Linjue Qian, Zihan Shi, Xinyue Wang, Lu Jia, Yang Xia   +6 more
semanticscholar   +1 more source

Stromal cell‐derived factor‐1/Exendin‐4 cotherapy facilitates the proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells in vitro and promotes periodontal bone regeneration in vivo

Cell Proliferation, 2021
Stromal cell‐derived factor‐1 (SDF‐1) actively directs endogenous cell homing. Exendin‐4 (EX‐4) promotes stem cell osteogenic differentiation. Studies revealed that EX‐4 strengthened SDF‐1‐mediated stem cell migration.
Qianyu Liang, L. Du, Rui Zhang, W. Kang, S. Ge   +4 more
semanticscholar   +1 more source

Capsaicin attenuates Porphyromonas gingivalis-suppressed osteogenesis of periodontal ligament stem cells via regulating mitochondrial function and activating PI3K/AKT/mTOR pathway.

Journal of Periodontal Research
BACKGROUND AND OBJECTIVE Prevention of periodontal bone resorption triggered by Porphyromonas gingivalis (P. gingivalis) is crucial for dental stability.
Weijia Wang, Zhi-Yan Zhou, Tian Ding, Susu Feng, Hong-Rui Liu, Mengmeng Liu, S. Ge   +6 more
semanticscholar   +1 more source

Quercetin reverses TNF-α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF-κB/NLRP3 inflammasome pathway

International Journal of Molecular Medicine, 2021
Quercetin (Quer) is a typical antioxidant flavonoid from plants that is involved in bone metabolism, as well as in the progression of inflammatory diseases.
Wen-Jing Zhang, Linglu Jia, Bin Zhao, Yixuan Xiong, Ya-Nan Wang, Jin Liang, X. Xu   +6 more
semanticscholar   +1 more source

Force-Induced Autophagy in Periodontal Ligament Stem Cells Modulates M1 Macrophage Polarization via AKT Signaling

Frontiers in Cell and Developmental Biology, 2021
Autophagy, a lysosomal degradation pathway, serves as a protective cellular mechanism in maintaining cell and tissue homeostasis under mechanical stimulation.
N. Jiang, Danqing He, Yu-Shi Ma, Jun-Xiang Su, Xiaowen Wu, Shengjie Cui, Zi-Xin Li, Yan-Heng Zhou, Hua-Jie Yu, Yan Liu   +9 more
semanticscholar   +1 more source

Mechanical force-activated CD109 on periodontal ligament stem cells governs osteogenesis and osteoclast to promote alveolar bone remodeling

Stem Cells Translational Medicine
Mechanical force-mediated bone remodeling is crucial for various physiological and pathological processes involving multiple factors, including stem cells and the immune response.
Yang Li, Yi Li, Chao Liu, Xinyi Yu, Ziqi Gan, L. Xiang, Jinxuan Zheng, Bo-Wen Meng, Rong-Cheng Yu, Xin Chen, X. Kou, Yang Cao, Tingting Ai   +12 more
semanticscholar   +1 more source

The effect of the Wnt pathway on the osteogenic differentiation of periodontal ligament stem cells in different environments [PDF]

PeerJ
Alveolar bone defects have always been an urgent problem in the oral cavity. For some patients with periodontal disease or undergoing orthodontic treatment or implant restoration, alveolar bone defects can greatly inconvenience clinical diagnosis and ...
Qi Su, Fengqiong Huang, XiuLei Fang, Qiang Lin   +3 more
doaj   +2 more sources