Results 101 to 110 of about 4,841,252 (345)

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update.

Journal of Clinical Oncology, 2020
PURPOSE To update the ASCO guideline on the recommended prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathy (CIPN) in adult cancer survivors.
C. Loprinzi, C. Lacchetti, J. Bleeker, G. Cavaletti, Cynthia Chauhan, D. Hertz, M. Kelley, A. Lavino, M. Lustberg, J. Paice, B. Schneider, Ellen M. Lavoie Smith, M. Smith, Thomas J. Smith, N. Wagner-Johnston, D. Hershman   +15 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Editorial: Out-of-field second primary cancer induction: Dosimetry and modelling

Frontiers in Oncology, 2022
Beatriz Sánchez-Nieto, Liliana Stolarczyk, Liliana Stolarczyk, Alexandru Dasu, Alexandru Dasu, Wayne D. Newhauser, Francisco Sánchez-Doblado   +6 more
doaj   +1 more source

Peripheral Doses Beyond Electron Applicators in Conventional C-Arm Linear Accelerators: A Systematic Literature Review

Technology in Cancer Research & Treatment
Background: This review investigates peripheral dose levels in electron beam treatments, comparing different manufacturers including Varian, Elekta, and Siemens.
Kapil Dev Maharaj BSc, MSc, Joshua Dass MPH, MHM, FRANZCR, FRACMA, Mounir Ibrahim BSc, MSc, PhD, ROCMPS, Talat Mahmood BSc, MSc, ROCMPS, Pejman Rowshanfarzad BSc, MSc, PhD   +4 more
doaj   +1 more source

Prenatal Tolerance Induction: Relationship between Cell Dose, Marrow T-Cells, Chimerism, and Tolerance

Cell Transplantation, 2008
It was reported that the dose of self-antigens can determine the consequence of deletional tolerance and donor T cells are critical for tolerance induction in mixed chimeras.
Jeng-Chang Chen M.D., Ming-Ling Chang, Shiu-Feng Huang, Pei-Yeh Chang, Marcus O. Muench, Ren-Huei Fu, Liang-Shiou Ou, Ming-Ling Kuo   +7 more
doaj   +1 more source

Clinical applications of custom-made vaginal cylinders constructed using three-dimensional printing technology. [PDF]

, 2016
PurposeThree-dimensional (3D) printing technology allows physicians to rapidly create customized devices for patients. We report our initial clinical experience using this technology to create custom applicators for vaginal brachytherapy.Material and ...
Cunha, Adam, Diederich, Chris, Hsu, I-Chow, Mellis, Katherine, Pouliot, Jean, Sethi, Rajni, Siauw, Timmy   +6 more
core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Peripheral neuropathy

Journal of Neurology, 2019
Type II mixed cryoglobulinemia is sustained by an oligoclonal production of IgM sharing rheumatoid activity and can be associated with renal, cutaneous, rheumatologic or neurological manifestations.
Lisa M. Shulman, Paul Dash, Nicole Villemarette-Pittman, Robert G. Miller, D. Gelinas, Patricia O’Connor, E. Leppik, Joel S. Steinberg, William B. Young, Stephen D. Silberstein, Wayne A. Henning, C. Kushida   +11 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source