Induction of Peripheral Tolerance in Ongoing Autoimmune Inflammation Requires Interleukin 27 Signaling in Dendritic Cells [PDF]
Frontiers in Immunology, 2017 Peripheral tolerance to autoantigens is induced via suppression of self-reactive lymphocytes, stimulation of tolerogenic dendritic cells (DCs) and regulatory T (Treg) cells.
Rodolfo Thomé +9 more
doaj +5 more sources
A red blood cell–based antigen delivery system to facilitate T cell epitope presentation to promote peripheral tolerance to ADAMTS13 in immune-mediated thrombotic thrombocytopenic purpura [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare and potentially fatal autoimmune disease caused by a severe ADAMTS13 functional deficiency, mediated by autoantibodies targeting ADAMTS13.
Margot Dierickx +7 more
doaj +2 more sources
Translating tolerogenic therapies to the clinic – where do we stand? [PDF]
Frontiers in Immunology, 2012 Manipulation of the immune system to prevent the development of a specific immune response is an ideal strategy to improve outcomes after transplantation.
Fadi eIssa, Kathryn J. Wood
doaj +2 more sources
The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance [PDF]
Journal of Immunology Research, 2018 Autoimmune regulator (AIRE), whose gene mutation is considered to be a causative factor of autoimmune polyglandular syndrome type 1 (APS1), is an important transcriptional regulator.
Bingjie Zhao +4 more
doaj +2 more sources
Dendritic Cells As Inducers of Peripheral Tolerance. [PDF]
Trends Immunol, 2017 Mechanisms of tolerance initiated in the thymus are indispensable for establishing immune homeostasis, but they may not be sufficient to prevent tissue-specific autoimmune diseases. In the periphery, dendritic cells (DCs) play a crucial tolerogenic role, extending the maintenance of immune homeostasis and blocking autoimmune responses.
Iberg CA, Jones A, Hawiger D.
europepmc +4 more sources
Global trends of peripheral immune tolerance research: a bibliometric and visualization analysis [PDF]
Frontiers in ImmunologyBackgroundPeripheral immune tolerance is a key mechanism for maintaining immune homeostasis and preventing autoimmune responses. Although numerous studies have explored its molecular and cellular basis, a comprehensive and systematic overview of the ...
Shixiao Kong +3 more
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Regulatory Cell Therapy in Organ Transplantation: Achievements and Open Questions
Frontiers in Immunology, 2021 The effective development of innovative surgical applications and immunosuppressive agents have improved remarkable advancements in solid organ transplantation.
Marta Fortunato +5 more
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IPEX Syndrome: Improved Knowledge of Immune Pathogenesis Empowers Diagnosis
Frontiers in Pediatrics, 2021 Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare monogenic autoimmune disease with variable clinical manifestations, ranging from early-onset severe autoimmunity, including enteropathy, eczema, and type 1 diabetes,
Federica Barzaghi, Laura Passerini
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The Role of Viral Infections in the Onset of Autoimmune Diseases
Viruses, 2023 Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance, leading to the inability to sufficiently differentiate between self and non-self.
Bhargavi Sundaresan +3 more
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Cells, 2021 Antigen-specific regulatory T cells play key immune suppressive roles in autoimmune disease models and regulate the peripheral tolerance achieved via anterior chamber-associated immune deviation (ACAID).
Shukkur M. Farooq, Hossam M. Ashour
doaj +1 more source