Results 11 to 20 of about 507,873 (296)

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance. [PDF]

Science, 2020
ElTanbouly MA, Zhao Y, Nowak E, Li J, Schaafsma E, Le Mercier I, Ceeraz S, Lines JL, Peng C, Carriere C, Huang X, Day M, Koehn B, Lee SW, Silva Morales M, Hogquist KA, Jameson SC, Mueller D, Rothstein J, Blazar BR, Cheng C, Noelle RJ.   +21 more
europepmc   +2 more sources

Accumulation of Self-Reactive Naive and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjogren's Syndrome [PDF]

, 2014
This work was funded by grants number 18237 and 20089 from Arthritis Research UK (http://www.arthritisresearchuk.org) to MB and the William Harvey Research Foundation.
A Cappione 3rd, A Hansen, A Hansen, A Hansen, A Hansen, A Kessel, B Chang, B Mietzner, C Vitali, Costantino Pitzalis, DI Stott, E Meffre, E Theander, Elisa Corsiero, F Barone, F Takemoto, H Mouquet, H Tsuboi, H Wardemann, IS Lossos, J Pijpe, J Samuels, Jay Reddy, JC Edwards, JF Scheid, JG Routsias, L Dawson, L Le Pottier, M Bombardieri, M Tsuiji, Michele Bombardieri, N Haneji, Nurhan Sutcliffe, P Youinou, S Salomonsson, S Yurasov, T Rogosch, T Tiller, T Tiller   +38 more
core   +6 more sources

On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance

Molecules, 2020
There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is well ...
Susanna Fürst, Zoltán S. Zádori, Ferenc Zádor, Kornél Király, Mihály Balogh, Szilvia B. László, Barbara Hutka, Amir Mohammadzadeh, Chiara Calabrese, Anna Rita Galambos, Pál Riba, Patrizia Romualdi, Sándor Benyhe, Júlia Timár, Helmut Schmidhammer, Mariana Spetea, Mahmoud Al-Khrasani   +16 more
doaj   +1 more source

Soluble monomeric human programmed cell death-ligand 1 inhibits the functions of activated T cells

Frontiers in Immunology, 2023
IntroductionThe presence of soluble human programmed cell death-ligand 1 (shPD-L1) in the blood of patients with cancer has been reported to be negatively correlated with disease prognosis.
Zhaoduan Liang, Zhaoduan Liang, Wenfang Chen, Yunzhuo Guo, Yunzhuo Guo, Yuefei Ren, Yuefei Ren, Ye Tian, Wenxuan Cai, Yifeng Bao, Qi Liu, Peng Ding, Yi Li, Yi Li   +13 more
doaj   +1 more source

Genetic regulation of peripheral tolerance [PDF]

Nature Reviews Immunology, 2012
openaire   +3 more sources

Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies. [PDF]

J Exp Med, 2017
Schroeder KMS, Agazio A, Strauch PJ, Jones ST, Thompson SB, Harper MS, Pelanda R, Santiago ML, Torres RM.   +8 more
europepmc   +2 more sources

Mechanistic and Biomarker Studies to Demonstrate Immune Tolerance in Multiple Sclerosis

Frontiers in Immunology, 2022
The induction of specific immunological tolerance represents an important therapeutic goal for multiple sclerosis and other autoimmune diseases. Sound knowledge of the target antigens, the underlying pathomechanisms of the disease and the presumed ...
María José Docampo, Andreas Lutterotti, Mireia Sospedra, Roland Martin   +3 more
doaj   +1 more source

Myocardial infarction primes autoreactive T cells through activation of dendritic cells [PDF]

, 2017
Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An example
Bouché, Ann, Carmeliet, Peter, De Prijck, Sofie, Gillebert, Thierry, Guilliams, Martin, Lambrecht, Bart, Ludewig, Burkhard, Martens, Liesbet, Nindl, Veronika, Saeys, Yvan, Scott, Charlotte, Sichien, Dorine, Van Der Borght, Katrien, Van Moorleghem, Justine, Vanheerswynghels, Manon   +14 more
core   +6 more sources

Forkhead-Box-P3 Gene Transfer in Human CD4+ T Conventional Cells for the Generation of Stable and Efficient Regulatory T Cells, Suitable for Immune Modulatory Therapy

Frontiers in Immunology, 2017
The development of novel approaches to control immune responses to self- and allogenic tissues/organs represents an ambitious goal for the management of autoimmune diseases and in transplantation.
Laura Passerini, Rosa Bacchetta
doaj   +1 more source

Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. [PDF]

, 2017
Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology.
Chen, Yiling, Cheng, Debra A, Hsu, Lih-Yun, Liang, Hong-Erh, Weiss, Arthur   +4 more
core   +2 more sources