Results 141 to 150 of about 1,895,537 (160)

Periprostatic Adipose Tissue: A Heavy Player in Prostate Cancer Progression

Current Opinion in Endocrine and Metabolic Research, 2020
Abstract Prostate is surrounded by a specific fat depot called periprostatic adipose tissue (PPAT) that contributes through paracrine mechanisms to prostate cancer (PCa) progression. Like other white adipose tissues, PPAT stores lipids and is an endocrine organ. However, PPAT is still poorly characterized.
David Estève, Cécile Manceau, Catherine MULLER   +2 more
exaly   +2 more sources

Influence of Adipocytokines in Periprostatic Adipose Tissue on Prostate Cancer Aggressiveness

Cytokine, 2016
To evaluate the correlation between the level of adipocytokines expression in periprostatic adipose tissue and the prostate cancer aggressiveness.The periprostatic adipose tissues were collected from 30 patients who underwent radical retropubic prostatectomy.
Qiang, Zhang, Li-Jiang, Sun, Zhi-Gang, Yang, Gui-Ming, Zhang, Ri-Cha, Huo   +4 more
exaly   +3 more sources

Increased apoptosis of periprostatic adipose tissue in VDR null mice

Journal of Cellular Biochemistry, 2004
AbstractThe vitamin D receptor (VDR) is a member of the steroid/retinoid receptor superfamily of nuclear receptors that controls mineral ion homeostatis and has potential tumor‐suppressive functions for various cancer types, specifically prostate cancer.
Meral, Guzey, Drazen, Jukic, Julie, Arlotti, Marie, Acquafondata, Rajiv, Dhir, Robert H, Getzenberg   +5 more
openaire   +2 more sources

Variable effects of periprostatic adipose tissue on prostate cancer cells: Role of adipose tissue lipid composition and cancer cells related factors

The Prostate, 2023
AbstractBackgroundPeriprostatic adipose tissue (PPAT) is likely to modulate prostate cancer (PCa) progression. We analyzed the variations in the effect of PPAT on cancer cells, according to its fatty acid (FA) composition and tumor characteristics.MethodsThe expression of markers of aggressiveness Ki67 and Zeb1, and epigenetic marks that could be ...
Mathilde Cancel, David Crottes, Dorine Bellanger, Frank Bruyère, Coralie Mousset, Michelle Pinault, Karine Mahéo, Gaëlle Fromont   +7 more
openaire   +2 more sources

Assessment of Periprostatic and Subcutaneous Adipose Tissue Lipolysis and Adipocyte Size From Men With Localized Prostate Cancer [PDF]

Cancers, 2020
The prostate is surrounded by periprostatic adipose tissue (PPAT), the thickness of which has been associated with more aggressive prostate cancer (PCa). There are limited data regarding the functional characteristics of PPAT, how it compares to subcutaneous adipose tissue (SAT), and whether in a setting of localized PCa, these traits are altered by ...
Gary Wittert, Lisa G Horvath, Barbara Meyer   +2 more
exaly   +4 more sources

Tumor Cell-Educated Periprostatic Adipose Tissue Acquires an Aggressive Cancer-Promoting Secretory Profile [PDF]

Cellular Physiology and Biochemistry, 2012
The microenvironment produces important factors that are crucial to prostate cancer (PCa) progression. However, the extent to which the cancer cells stimulate periprostatic adipose tissue (PPAT) to produce these proteins is largely unknown. Our purpose was to determine whether PCa cell-derived factors influence PPAT metabolic activity.Primary cultures ...
Antonio Morais, Andreia S M Azevedo, Maria José Oliveira   +2 more
exaly   +3 more sources

Specificities of mammary and periprostatic adipose tissues: A perspective from cancer research

Annales d'Endocrinologie
In addition to the major subcutaneous and visceral adipose tissues (AT), other adipose depots are dispersed throughout the body and are found in close interaction with proximal organs such as mammary and periprostatic AT (MAT and PPAT respectively). These ATs have an effect on proximal organ function during physiological processes and diseases such as ...
Marie, Rebeaud, Mathilde, Lacombe, Frédérique, Fallone, Delphine, Milhas, Mathieu, Roumiguié, Charlotte, Vaysse, Camille, Attané, Catherine, Muller   +7 more
openaire   +2 more sources

Extracellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: implication for prostate cancer aggressiveness

The Journal of Pathology
Abstract One of the most striking features of the adipose depot surrounding the prostate [periprostatic adipose tissue (PPAT)] is that its accumulation is independent of body mass index. Its volume varies considerably between individuals, with some patients exhibiting abundant PPATs, which have been correlated to the occurrence of ...
Estève, David, Toulet, Aurélie, Roumiguié, Mathieu, Bu, Dawei, Lacombe, Mathilde, Péricart, Sarah, Belles, Chloé, Manceau, Cécile, Houël, Cynthia, Ducoux-Petit, Manuelle, van Acker, Nathalie, Dauvillier, Stéphanie, Jia, Yiyue, Hernandez, Marine, Moutahir, Mohammed, Franchet, Camille, Doumerc, Nicolas, Thoulouzan, Mathieu, Le Gonidec, Sophie, Valet, Philippe, Malavaud, Bernard, Burlet-Schiltz, Odile, Bouloumié, Anne, Scherer, Philipp, Milhas, Delphine, Muller, Catherine   +25 more
openaire   +3 more sources

Mapping Risk: Linking Periprostatic Adipose Tissue with PI-RADS for Prostate Cancer Stratification

Purpose Methods and materials Results Conclusion Personal information and conflict of interest ...
Stoicescu, Roxana, Stoicescu, Roxana
openaire   +1 more source

956 ANDROGEN PRODUCTION IN PERIPROSTATIC ADIPOSE TISSUE IN PROSTATE CANCER PATIENTS

Journal of Urology, 2012
Seiji Arai, Yasuhiro Shibata, Hidekazu Koike, Hiroshi Matsui, Kazuto Ito, Seijiro Honma, Kazuhiro Suzuki   +6 more
openaire   +1 more source