Results 141 to 150 of about 288,150 (296)

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

Patient selection for cytoreductive surgery and HIPEC for the treatment of peritoneal metastases from colorectal cancer

Cancer Management and Research, 2017
Geert A Simkens, Koen P Rovers, Simon W Nienhuijs, Ignace H de Hingh Department of Surgical Oncology, Catharina Cancer Institute, Eindhoven, The Netherlands Abstract: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal ...
Simkens GA, Rovers KP, Nienhuijs SW, de Hingh IH   +3 more
doaj  

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Perioperative Management for Colorectal Peritoneal Metastases [PDF]

Clinical Colorectal Cancer, 2018
Kim, Bradford J., Passot, Guillaume
openaire   +2 more sources

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Late peritoneal metastases of medulloblastoma following ventriculoperitoneal shunting: A case report. [PDF]

Radiol Case Rep
Ouazzani Chahdi H, Akammar A, Chaouche I, El Bouardi N, Haloua M, Alami B, Alaoui Lamrani MY, Maaroufi M, Boubbou M.   +8 more
europepmc   +1 more source

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single‐Cell Level in CTCs From HR+/HER2− Metastatic Breast Cancer

Cancer Science, EarlyView.
Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Tania Rossi, Michela Palleschi, Caterina Gianni, Filippo Merloni, Alessandra Virga, Sara Bandini, Davide Angeli, Michela Tebaldi, Roberta Maltoni, Paola Ulivi, Antonino Musolino   +10 more
wiley   +1 more source

Impact of the Tumor Microenvironment and Molecular Oncology in Peritoneal Metastases. [PDF]

Cancers (Basel)
Khurshid A, Chalasani HS, Jacobs A, Kasakewitch JP, Avila K, Brown ZJ.   +5 more
europepmc   +1 more source

A unique interplay of access and selection shapes peritoneal metastasis evolution in colorectal cancer [PDF]

Whether metastasis in humans can be accomplished by most primary tumor cells or requires the evolution of a specialized trait remains an open question.
Raicu, Mihaela G, Watson, Emma V, Wiezer, Rene Mj, Ubink, Inge, Kops, Geert Jpl, Gorelick, Alexander N, Lansu, Nico, Hung, Wei-Ting, Naxerova, Kamila, Corcoran, Ryan B, Lennerz, Jochen K, Giunta, Peter, Boerma, Djamila, Juric, Dejan, Kranenburg, Onno, Wassenaar, Emma Ce, Cheek, David M, Kucukkose, Emre, Blohmer, Martin, Klaasen, Sjoerd J, Boland, Genevieve, Lee, I-Hsiu, Getz, Gad, Degner, Sebastian, Regenerative Medicine and Stem Cells, Hubrecht Institute with UMC, CMM, Lab Translational Oncology, MS CGO, Cancer   +29 more
core  

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

Cell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo, Qiang Qin, Wenting She, Xiangying Wang, Xiqin Li, Chenxuan Shu, Ruohan Li, Ziwei Li, Dongjie Fu, Yan He, Qingsong Ye   +10 more
wiley   +1 more source