Results 121 to 130 of about 288,150 (296)

Morbidity and Mortality of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients Aged 70 Years and Older: A Two‐Center 10‐Year Experience

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is established for peritoneal surface malignancies, but its use in older patients is debated. We assessed CRS‐HIPEC morbidity and mortality in patients aged ≥ 70 years using a cohort of younger patients as a comparator.
Ali Ediz Kıvanç, Mehmet Oduncu, Pırıltı Özcan, Özgül Düzgün, Neşet Köksal   +4 more
wiley   +1 more source

Development and External Validation of a Postoperative Risk Score for Venous Thromboembolism in Epithelial Ovarian Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a major complication in women with epithelial ovarian cancer (EOC). We aimed to develop and externally validate an early postoperative risk score to identify EOC patients at increased risk of VTE after debulking surgery.
Qiu‐Lin Cui, Yu‐Shi He, Xuan‐Hui Wang, Cheng Li, Gang Wang, Ming Chen, Shu‐Min Chen   +6 more
wiley   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Routing immunomodulatory cytokine-encoded mRNAs to the omentum: turning an enemy into an ally in peritoneal metastasis

OncoImmunology
Peritoneal metastases remain a significant clinical challenge owing to the immunosuppressive nature of the omentum, which serves as a protective niche for disseminated tumor cells.
Leire Arrizabalaga, Ignacio Melero, Pedro Berraondo, Fernando Aranda   +3 more
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Is pressurized intraperitoneal aerosol chemotherapy (PIPAC) feasible in a rabbit model of gastric peritoneal metastases?

International audienceCurrently, peritoneal metastases (PM) represent a poor prognosis in cancer and chemotherapy techniques are very limited (Cortés-Guiral et al 2021 Nat RevDis Primers). Pressurized intra-peritoneal aerosol chemotherapy (PIPAC) appears
Bardet, Sylvia M., Durand-Fontanier, Sylvaine, Yardin, C., Brandy, Matteo, Perrin, Marie-Laure, Taibi, Abdelkader   +5 more
core  

Dihydrotanshinone I Targets MIF to Inhibit GSK‐3β/β‐Catenin Axis‐Mediated Invasion and Metastasis in Gastric Cancer

Phytotherapy Research, EarlyView.
DHT directly binds to MIF and subsequently blunts AKT signaling, which restores the kinase activity of GSK‐3β. The reactivated GSK‐3β then promotes the phosphorylation (Ser33/37/Thr41) and proteasomal degradation of β‐catenin, thereby preventing its nuclear translocation and inhibiting the transcription of EMT‐related genes (e.g., Snail and Twist ...
Chuhang Wang, Xiaochen Ni, Yuyan Pan, Wei Fan, Jianing Guo, Kaiyuan Zhang, Mingsi Zhang, Linfeng Zheng, Yunhai Wei, Tao Jiang, Guangji Zhang   +10 more
wiley   +1 more source

The burden of peritoneal metastases

Since reliable and up-to-date epidemiological information on peritoneal metastases is currently lacking, the aim of this thesis was to provide insight into the burden of peritoneal metastases by exploring epidemiological and clinical aspects from a variety of primary cancers.
openaire   +1 more source

Thrombocytosis and tumour distribution predict outcome in dogs with hepatocellular carcinoma: A multi‐institutional retrospective analysis

Veterinary Record, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is the most common canine hepatobiliary tumour. This study aimed to determine which criteria influenced outcome of HCC in a modern population of dogs across eight institutions. Methods The medical records of 106 dogs with HCC were retrospectively reviewed.
Emily A. Janik, MacKenzie A. Pellin, Dawn M. Clarke   +2 more
wiley   +1 more source