Results 161 to 170 of about 288,150 (296)

Tumour deposits are associated with increased metastatic risk in colorectal cancer: a population‐based analysis of metastatic patterns and burden

Histopathology, EarlyView.
In this population‐based cohort of 3505 patients with colorectal cancer without distant metastases at diagnosis, tumour deposits are independently associated with an increased risk of distant metastases (HR 1.34, 95% CI 1.03–1.74). This finding supports consideration of tumour deposits in future risk stratification strategies.
Yao Shu, Nelleke P M Brouwer, Marloes A G Elferink, Johannes H W de Wilt, Femke Simmer, Iris D Nagtegaal   +5 more
wiley   +1 more source

Detection and treatment of peritoneal metastases in colon cancer: COLOPEC trial compared to routine practice. [PDF]

Colorectal Dis
Hochstenbach I, Hamm JJM, Rademaker E, Aalbers AGJ, Boerma D, van Grevenstein WMU, Hemmer PHJ, De Hingh IHJT, Kok NFM, Tuynman JB, Madsen EVE, de Wilt JHW, Consten ECJ, van Westreenen HL, Tanis PJ, COLOPEC Collaborators Group, Dutch Snapshot Research Group and Dutch Complex Colon Cancer Initiative.   +16 more
europepmc   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Secondary Cytoreductive Surgery ± Hyperthermic Intraperitoneal Chemotherapy for Recurrent Colorectal Cancer Peritoneal Metastases. [PDF]

Ann Surg Oncol
Oppat KM, Bennett FJ, Patel SH, Raoof M, Baumgartner JM, Mogal HD, Lambert LA, Abbott DE, Greer JB, Grotz TE, Fournier KF, Dineen SP, Powers B, Zaidi MY, Winer JH, Russell MC, Staley CA, Cloyd JM, Maithel SK, Concors SJ.   +19 more
europepmc   +1 more source

A Multidimensional Framework for Interpreting Macrophage Markers in the Era of Cellular Heterogeneity

Immunology, EarlyView.
Macrophage markers should be interpreted as context‐dependent biological readouts rather than deterministic cell identifiers. This Review proposes a multidimensional framework integrating lineage, identity, and functional state across complementary experimental modalities to enable a more accurate interpretation of macrophage heterogeneity.
Alessandro Palma
wiley   +1 more source

Distinct Patterns of Colorectal Peritoneal Metastases at Initial and Repeat Cytoreductive Surgery. [PDF]

World J Surg
Sarofim M, Morris DL.
europepmc   +1 more source

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Updated S2k hidradenitis suppurativa (HS) guidelines provide expert consensus on diagnosis, assessment and comorbidities. Expanded substantially since the 2015 version, they reflect rapid growth in HS literature and aim to improve generalist‐level patient care through evidence‐informed, consensus‐based guidance.
G. B. E. Jemec, B. Villumsen, K. R. van Straalen, H. H. van der Zee, S. Valiukevičienė, T. Tzellos, J. C. Szepietowski, A. Szegedi, D. M. L. Saunte, M. Romanelli, H. Raynal, F. Prignano, E. P. Prens, M. Podda, A. Nassif, A. Molina‐Leyva, Ł. Matusiak, A. V. Marzano, B. M. McGrath, A. I. Liakou, B. Kirby, L. Kemény, E. Just, D. Ioannidis, J. R. Ingram, R. E. Hunger, B. Horváth, P. Guillem, Ø. Grimstad, E. J. Giamarellos‐Bourboulis, M. Dolenc‐Voljč, V. Del Marmol, Z. Bukvić Mokos, V. Bettoli, F. Benhadou, F. G. Bechara, C. C. Zouboulis   +36 more
wiley   +1 more source

The Negative Impact of a Non-Therapeutic Laparotomy in Patients With Inoperable Colorectal Peritoneal Metastases. [PDF]

J Surg Oncol
Heuvel TVD, Kesteren LV, Nienhuijs S, Burger P, Buffart T, Tuynman J, Hingh I.   +6 more
europepmc   +1 more source

Comparison of Uncovered and Covered Biliary SEMS for the Salvage of Obstructed SEMS: A Multicenter Retrospective Propensity Score–Weighted Study

Journal of Gastroenterology and Hepatology, EarlyView.
In patients undergoing secondary SEMS placement after initial uncovered stent failure, fully covered and uncovered SEMSs showed comparable patency, survival, and safety. However, mechanisms of recurrent biliary obstruction differed by stent type, with tumor ingrowth in uncovered SEMSs and sludge or food impaction in fully covered SEMSs.
Ho Seung Lee, Gunn Huh, Sung Hyun Cho, Dongwook Oh, Jae Min Lee, Tae Jun Song, Hoonsub So, Hong‐Sik Lee, Dong‐Wan Seo   +8 more
wiley   +1 more source

Resolution of peritoneal metastases in CLDN18.2-positive gastric cancer treated with CAPOX plus zolbetuximab. [PDF]

Jpn J Clin Oncol
Midorikawa H, Hokamura N, Fukasawa T, Fukagawa T.   +3 more
europepmc   +1 more source