Results 181 to 190 of about 830,673 (331)

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Morphology and Pathophysiology of 10 Different Types of Peritoneal Metastases. [PDF]

J Surg Oncol
Sugarbaker PH, Liang JJ.
europepmc   +1 more source

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single‐Cell Level in CTCs From HR+/HER2− Metastatic Breast Cancer

Cancer Science, EarlyView.
Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Tania Rossi, Michela Palleschi, Caterina Gianni, Filippo Merloni, Alessandra Virga, Sara Bandini, Davide Angeli, Michela Tebaldi, Roberta Maltoni, Paola Ulivi, Antonino Musolino   +10 more
wiley   +1 more source

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: a single-institution experience. [PDF]

Radiol Oncol
Pilko G, Petric R.
europepmc   +1 more source

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

Cell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo, Qiang Qin, Wenting She, Xiangying Wang, Xiqin Li, Chenxuan Shu, Ruohan Li, Ziwei Li, Dongjie Fu, Yan He, Qingsong Ye   +10 more
wiley   +1 more source

Secondary Cytoreductive Surgery ± Hyperthermic Intraperitoneal Chemotherapy for Recurrent Colorectal Cancer Peritoneal Metastases. [PDF]

Ann Surg Oncol
Oppat KM, Bennett FJ, Patel SH, Raoof M, Baumgartner JM, Mogal HD, Lambert LA, Abbott DE, Greer JB, Grotz TE, Fournier KF, Dineen SP, Powers B, Zaidi MY, Winer JH, Russell MC, Staley CA, Cloyd JM, Maithel SK, Concors SJ.   +19 more
europepmc   +1 more source

Surgical removal of a perirectal melanoma through sphincterotomy and rectal wall resection in a horse

Equine Veterinary Education, EarlyView.
Summary Melanomas are among the most frequent neoplasms in grey horses. Deep perirectal melanomas, however, are uncommon and challenging to excise due to their proximity to the peritoneal reflection. This report describes the successful standing removal of a large (16 × 8 × 6 cm) perirectal melanoma firmly adherent to the dorsal rectal wall in a 19 ...
R. Becker, C. Koch, M. de Preux
wiley   +1 more source

Distinct Patterns of Colorectal Peritoneal Metastases at Initial and Repeat Cytoreductive Surgery. [PDF]

World J Surg
Sarofim M, Morris DL.
europepmc   +1 more source

Clinical and surgical findings in a mare with unilateral ovarian fibroleiomyoma and adhesions

Equine Veterinary Education, EarlyView.
Summary This case report describes the clinical presentation, ultrasonographic findings, surgical management and outcome of a 7‐year‐old Warmblood mare presented for recurrent colic, weight loss and poor performance. Rectal palpation identified a firm mass in the left caudal abdomen, which appeared on ultrasonography as a large, fluid‐filled, cyst‐like
N. Scilimati, P. Berni, E. Blanc, M. Di Pentima, F. Leonardi, S. Napoli, C. Palmieri, M. Ruggeri, R. Gialletti   +8 more
wiley   +1 more source

The Negative Impact of a Non-Therapeutic Laparotomy in Patients With Inoperable Colorectal Peritoneal Metastases. [PDF]

J Surg Oncol
Heuvel TVD, Kesteren LV, Nienhuijs S, Burger P, Buffart T, Tuynman J, Hingh I.   +6 more
europepmc   +1 more source