Results 81 to 90 of about 43,516 (333)

Identification of perivascular space dynamics with CT and MRI – Analysis with Hounsfield unit and point value measurements [PDF]

Journal of Research in Clinical Medicine
Introduction: This research aims to delineate the dynamic characteristics of perivascular spaces (PVS) using computed tomography (CT) and magnetic resonance imaging (MRI) examinations and to offer insights for differential diagnosis. Hounsfield Unit (HU)
Ziya Asan, Aydan Koysuren, Hatice Duygu Ciftci Sivri   +2 more
doaj   +1 more source

Centrum Semiovale Perivascular Space and Amyloid Deposition in Spontaneous Intracerebral Hemorrhage. [PDF]

, 2021
BACKGROUND AND PURPOSE: We explored whether high-degree magnetic resonance imaging–visible perivascular spaces in centrum semiovale (CSO) are more prevalent in cerebral amyloid angiopathy (CAA) than hypertensive small vessel disease and their ...
Tsai, Hsin-Hsi, Pasi, Marco, Jeng, Jiann-Shing, Chen, Ya-Fang, Yen, Ruoh-Fang, Huang, Chi-Ching, MD, Gurol, M Edip, Tsai, Li-Kai, Lee, Bo-Ching   +8 more
core  

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Quantitative evaluation of normal cerebrospinal fluid flow in Sylvian aqueduct and perivascular spaces of middle cerebral artery and circle of Willis using 2D phase-contrast MRI imaging

Frontiers in Neuroscience
IntroductionRecently, it was proposed that CSF flow comprises a critical part of the glymphatic system, playing a role in various brain abnormalities from Alzheimer’s disease to hydrocephalus.
Rosemarie Faustina D. Le, Christof Karmonik, Angelique S. Regnier-Golanov, Eugene V. Golanov, Gavin W. Britz   +4 more
doaj   +1 more source

Opercular Perivascular Space Mimicking a Space-Occupying Brain Lesion: A Short Case Series. [PDF]

Diagnostics (Basel)
A newly recognized fourth type of perivascular space has recently been described in the radiological literature. Despite its growing relevance, many radiologists are still unfamiliar with its imaging characteristics, often leading to misinterpretation as
Tumelkans R, Eraslan C, Balodis A.
europepmc   +2 more sources

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Targeting the brain’s glymphatic pathway: A novel therapeutic approach for cerebral small vessel disease

Neural Regeneration Research
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels, often leading to stroke and dementia.
Yuhui Ma, Yan Han
doaj   +1 more source

Perivascular tissue resident memory T cells as therapeutic target in multiple sclerosis [PDF]

, 2020
Introduction: Multiple sclerosis (MS) is characterized by inflammatory attacks of infiltrating leukocytes at onset but evolves into a smoldering, progressive disease within the central nervous system at its later stages.
Hsiao, C.-C. (Cheng-Chih), Hamann, J. (Jörg), Smolders, J. (Joost), Hsiao, Cheng-Chih, Smolders, Joost, Huitinga, Inge, Fransen, Nina L., Huitinga, I. (Inge), Fransen, Nina L, Fransen, N.L. (Nina L.), Smolders, Joost; id_orcid, Hamann, Jörg   +11 more
core   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source