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Mitochondrial Permeability Transition

Cells, 2022
The mitochondrial permeability transition (PT) is a phenomenon that can be broadly defined as an increase in the permeability of the mitochondrial inner membrane [...]
Paolo Bernardi, Evgeny Pavlov
doaj   +5 more sources

Shedding light on the mitochondrial permeability transition [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2011
The mitochondrial permeability transition is an increase of permeability of the inner mitochondrial membrane to ions and solutes with an exclusion size of about 1500Da. It is generally accepted that the permeability transition is due to opening of a high-conductance channel, the permeability transition pore.
RICCHELLI F, SILEIKYTE J, BERNARDI, PAOLO   +2 more
core   +8 more sources

Perspectives on the mitochondrial permeability transition [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1998
AbstractThe permeability transition, a sudden permeability increase of the inner mitochondrial membrane that is greatly favored by Ca2+ accumulation, has puzzled mitochondrial scientists for more than 40 years. It is now recognized that this phenomenon is mediated by opening a high conductance channel (the mitochondrial permeability transition pore ...
BERNARDI, PAOLO, BASSO E, COLONNA R, COSTANTINI, PAOLA, DI LISA, FABIO, ERIKSSON O, FONTAINE E, FORTE M, ICHAS F, MASSARI S, NICOLLI, ANNAMARIA, PETRONILLI V, SCORRANO, LUCA   +12 more
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Virus‐induced permeability transition in mitochondria [PDF]

FEBS Letters, 2000
Isolated rat liver mitochondria undergo permeability transition after supplementation with a suspension of tobacco mosaic virus. Four mitochondrial parameters proved the opening of the permeability transition pore in the inner mitochondrial membrane: increased oxygen consumption, collapse of the membrane potential, release of calcium ions from ...
Zorova, Ljubava D., Krasnikov, Boris F., Kuzminova, Alevtina E., Polyakova, Irina A., Dobrov, Eugeny N., Zorov, Dmitry B.   +5 more
openaire   +3 more sources

The permeability transition in plant mitochondria: the missing link [PDF]

Frontiers in Plant Science, 2015
The synthesis of ATP in mitochondria is dependent on a low permeability of the inner membrane. Nevertheless, mitochondria can undergo an increased permeability to solutes, named permeability transition (PT) that is mediated by a pore (PTP).
Marco eZancani, Valentino eCasolo, Elisa ePetrussa, Carlo ePeresson, Sonia ePatui, Alberto eBertolini, Valentina eDe Col, Enrico eBraidot, Francesco eBoscutti, Angelo eVianello   +9 more
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Properties of the Permeability Transition of Pea Stem Mitochondria [PDF]

Frontiers in Physiology, 2018
In striking analogy with Saccharomyces cerevisiae, etiolated pea stem mitochondria did not show appreciable Ca2+ uptake. Only treatment with the ionophore ETH129 (which allows electrophoretic Ca2+ equilibration) caused Ca2+ uptake followed by increased ...
Valentina De Col, Elisa Petrussa, Valentino Casolo, Enrico Braidot, Giovanna Lippe, Antonio Filippi, Carlo Peresson, Sonia Patui, Alberto Bertolini, Valentina Giorgio, Vanessa Checchetto, Angelo Vianello, Paolo Bernardi, Marco Zancani   +13 more
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Postconditioning Inhibits Mitochondrial Permeability Transition [PDF]

Circulation, 2005
Background— Brief periods of ischemia performed just at the time of reperfusion can reduce infarct size, a phenomenon called “postconditioning.” After reflow, opening of the mitochondrial permeability transition pore (mPTP) has been involved in lethal reperfusion injury.
Laurent, Argaud, Odile, Gateau-Roesch, Olivier, Raisky, Joseph, Loufouat, Dominique, Robert, Michel, Ovize   +5 more
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Occurrence and Characteristics of the Mitochondrial Permeability Transition in Plants [PDF]

Journal of Biological Chemistry, 2002
The behavior of purified potato mitochondria toward the main effectors of the animal mitochondrial permeability transition has been studied by light scattering, fluorescence, SDS-polyacrylamide gel electrophoresis, and immunoblotting techniques. The addition of Ca(2+) induces a phosphate-dependent swelling that is fully inhibited by cyclosporin A if ...
Arpagaus S, Rawyler A, Braendle R
openaire   +5 more sources

Structural heterogeneity and permeability in faulted eolian sandstone: Implications for subsurface modeling of faults [PDF]

, 2002
We determined the structure and permeability variations of a 4 km-long normal fault by integrating surface mapping with data from five boreholes drilled through the fault (borehole to tens of meters scale).
Forster, C.B., Robeson, K.R., Snelgrove, S., Shipton, Z.K., Evans, J.P.   +4 more
core   +9 more sources

Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT

Molecules, 2021
The permeability transition (PT) is an increased permeation of the inner mitochondrial membrane due to the opening of the PT pore (PTP), a Ca2+-activated high conductance channel involved in Ca2+ homeostasis and cell death.
Andrea Carrer, Claudio Laquatra, Ludovica Tommasin, Michela Carraro   +3 more
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