How the Wnt signaling pathway protects from neurodegeneration: The Mitochondrial Scenario
Frontiers in Cellular Neuroscience, 2015 Alzheimer´s disease (AD) is the most common neurodegenerative disorder and is characterized by progressive memory loss and cognitive decline. One of the hallmarks of AD is the overproduction of amyloid-beta aggregates that range from the toxic soluble ...
Macarena S. Arrázola +5 more
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Permeability evolution during progressive development of deformation bands in porous sandstones [PDF]
, 2003 Triaxial deformation experiments were carried out on large (0.1 m) diameter cores of a porous sandstone in order to investigate the evolution of bulk sample permeability as a function of axial strain and effective confining pressure. The log permeability
Kwon, O. +7 more
core +1 more source
The mitochondrial permeability transition pore: A mystery solved?
Frontiers in Physiology, 2013 The permeability transition denotes an increase of the mitochondrial inner membrane permeability to solutes with molecular masses up to about 1,500 Da. It is presumed to be mediated by opening of a channel, the permeability transition pore (PTP), whose ...
Paolo eBernardi, Paolo eBernardi
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A Novel Conceptual Model for the Dual Role of FOF1-ATP Synthase in Cell Life and Cell Death
Biomolecular Concepts, 2020 The mitochondrial permeability transition (MPT) has been one of the longstanding enigmas in biology. Its cause is currently at the center of an extensive scientific debate, and several hypotheses on its molecular nature have been put forward. The present
Nath Sunil
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Meikuang Anquan, 2023 In order to study the influencing factors of coal permeability enhancement under the effect of phase change thermal storage, coal permeability enhancement experiment and coal gas seepage experiment were conducted, and the effects of thermal storage ...
XU Deyu, MA Haojuan, CUI Hongqing, WANG Tianyu, LIU Tao
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Loading rate dependence of permeability evolution in porous aeolian sandstones [PDF]
, 2004 Mechanical properties of rocks are characterized by their notable dependence on the applied deformation rate. However, little is known about the strain rate dependence of fluid flow properties since most laboratory tests are conducted using a single ...
Ira O. Ojala +8 more
core +1 more source
, 2022 The opening of mitochondrial permeability transition pore (mPTP) plays a fundamental role in cell apoptosis regulation, ischemia–reperfusion injury, and neurodegenerative disorders.
Weiying Lin (1670665) +9 more
core +1 more source
C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation [PDF]
, 2012 Hemorrhagic shock leads to hepatic hypoperfusion and activation of mitogen-activated stress kinases (MAPK) like c-Jun N-terminal kinase (JNK) 1 and 2. Our aim was to determine whether mitochondrial dysfunction leading to hepatic necrosis and apoptosis ...
Zhong, Zhi +6 more
core +1 more source
The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition
Cells, 2020 The mitochondrial permeability transition, a Ca2+-induced significant increase in permeability of the inner mitochondrial membrane, plays an important role in various pathologies.
Nickolay Brustovetsky
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Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore. [PDF]
PLoS ONE, 2011 Antamanide is a cyclic decapeptide derived from the fungus Amanita phalloides. Here we show that antamanide inhibits the mitochondrial permeability transition pore, a central effector of cell death induction, by targeting the pore regulator cyclophilin D.
Luca Azzolin +8 more
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