Results 41 to 50 of about 2,545,611 (287)

Properties of the permeability transition in VDAC1−/− mitochondria

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006
Opening of the permeability transition pore (PTP), a high-conductance mitochondrial channel, causes mitochondrial dysfunction with Ca2+ deregulation, ATP depletion, release of pyridine nucleotides and of mitochondrial apoptogenic proteins. Despite major efforts, the molecular nature of the PTP remains elusive.
KRAUSKOPF A, ERIKSSON O, CRAIGEN WJ, FORTE MA, BERNARDI, PAOLO   +4 more
openaire   +4 more sources

Mitochondrial permeability transition pore and postconditioning [PDF]

Cardiovascular Research, 2006
Postconditioning has recently been described as a powerful cardioprotection that prevents lethal reperfusion injury. Growing evidence suggests that mitochondrial permeability transition may be a key event in postconditioning. This proposition arises from the complementary observations that: (1) conditions for the mitochondrial permeability transition ...
Odile, Gateau-Roesch, Laurent, Argaud, Michel, Ovize   +2 more
openaire   +2 more sources

Melanocytes from patients affected by Ullrich congenital muscular dystrophy and Bethlem myopathy have dysfunctional mitochondria that can be rescued with cyclophilin inhibitors

Frontiers in Aging Neuroscience, 2014
Ullrich congenital muscular dystrophy and Bethlem myopathy are caused by mutations in collagen VI genes, which encode an extracellular matrix protein; yet mitochondria play a major role in disease pathogenesis through a short circuit caused by ...
Alessandra eZulian, Francesca eTagliavini, Francesca eTagliavini, Erika eRizzo, Erika eRizzo, Camilla ePellegrini, Francesca eSardone, Francesca eSardone, Nicoletta eZini, Nicoletta eZini, Nadir Mario Maraldi, Spartaco eSanti, Spartaco eSanti, Cesare eFaldini, Luciano eMerlini, Valeria ePetronilli, Valeria ePetronilli, Paolo eBernardi, Paolo eBernardi, Patrizia eSabatelli, Patrizia eSabatelli   +20 more
doaj   +1 more source

Mitochondrial Permeability Transition, Cell Death and Neurodegeneration. [PDF]

Cells
Neurodegenerative diseases are chronic conditions occurring when neurons die in specific brain regions that lead to loss of movement or cognitive functions.
Baev AY, Vinokurov AY, Potapova EV, Dunaev AV, Angelova PR, Abramov AY.   +5 more
europepmc   +2 more sources

Mitochondrial Involvement and Impact in Aging Skeletal Muscle

Frontiers in Aging Neuroscience, 2014
Atrophy is a defining feature of aging skeletal muscle that contributes to progressive weakness and an increased risk of mobility impairment, falls, and physical frailty in very advanced age.
Russell T. Hepple
doaj   +1 more source

Novel insights into the mitochondrial permeability transition [PDF]

Cell Cycle, 2014
Alavian and colleagues recently provided further evidence in support of the notion that the c subunit of the mitochondrial F1FO ATP synthase constitutes the long-sought pore-forming unit of the supramolecular complex responsible for the so-called 'mitochondrial permeability transition' (MPT).
BONORA, Massimo, Bravo San Pedro, José Manuel, Kroemer, Guido, Galluzzi, Lorenzo, PINTON, Paolo   +4 more
openaire   +3 more sources

Astaxanthin Inhibits Mitochondrial Permeability Transition Pore Opening in Rat Heart Mitochondria

Antioxidants, 2019
The mitochondrion is the main organelle of oxidative stress in cells. Increased permeability of the inner mitochondrial membrane is a key phenomenon in cell death. Changes in membrane permeability result from the opening of the mitochondrial permeability
Yulia Baburina, Roman Krestinin, Irina Odinokova, Linda Sotnikova, Alexey Kruglov, Olga Krestinina   +5 more
doaj   +1 more source

Signal transduction to the permeability transition pore [PDF]

FEBS Letters, 2010
The permeability transition pore (PTP) is an inner mitochondrial membrane channel that has been thoroughly characterized functionally, yet remains an elusive molecular entity. The best characterized PTP‐regulatory component, cyclophilin (CyP) D, is a matrix protein that favors pore opening.
RASOLA, ANDREA, SCIACOVELLI, MARCO, PANTIC, BORIS, BERNARDI, PAOLO   +3 more
openaire   +3 more sources

Requirement for ER-mitochondria Ca2+ transfer, ROS production and mPTP formation in L-asparaginase-induced apoptosis of acute lymphoblastic leukemia cells

Frontiers in Cell and Developmental Biology, 2023
Acute lymphoblastic leukemia (aLL) is a malignant cancer in the blood and bone marrow characterized by rapid expansion of lymphoblasts. It is a common pediatric cancer and the principal basis of cancer death in children.
Jung Kwon Lee, Jesusa L. Rosales, Ki-Young Lee   +2 more
doaj   +1 more source

Permeability Of Dentine. [PDF]

, 2003
This is an update on the present integrated knowledge regarding dentine permeability that assumed a role in dentine sensitivity and contribute clinically to the effective bonding properties of restorative dental materials.
Che Ghazali, Farid
core   +1 more source