OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling [PDF]
Mitochondrion, 2020 Optic atrophy type 1 protein (OPA1), a dynamin-related GTPase, that, in addition to mitochondrial fusion, plays an important role in maintaining the structural organization and integrity of the inner mitochondrial membrane (IMM). OPA1 exists in two forms:
Sabzali Javadov, Sehwan Jang
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Simple kinetic model of mitochondrial swelling in cardiac cells [PDF]
Journal of Cellular Physiology, 2018 Mitochondria play an important role in both cell survival and cell death. In response to oxidative stress, they undergo opening of non‐selective permeability transition pores (PTP) in the inner mitochondrial membrane.
Sabzali Javadov, Vladimir I. Makarov
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The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability. [PDF]
Sci Rep, 2020 The iron chelator Deferasirox (DFX) causes severe toxicity in patients for reasons that were previously unexplained. Here, using the kidney as a clinically relevant in vivo model for toxicity together with a broad range of experimental techniques ...
Gottwald EM +15 more
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Different approaches to modeling analysis of mitochondrial swelling. [PDF]
Mitochondrion, 2018 Mitochondria are critical players involved in both cell life and death through multiple pathways. Structural integrity, metabolism and function of mitochondria are regulated by matrix volume due to physiological changes of ion homeostasis in cellular ...
Javadov S, Chapa-Dubocq X, Makarov V.
europepmc +2 more sources
The targeted anti-oxidant MitoQ causes mitochondrial swelling and depolarization in kidney tissue. [PDF]
Physiol Rep, 2018 Kidney proximal tubules (PTs) contain a high density of mitochondria, which are required to generate ATP to power solute transport. Mitochondrial dysfunction is implicated in the pathogenesis of numerous kidney diseases.
Gottwald EM +6 more
europepmc +2 more sources
Study of mitochondrial swelling, membrane fluidity and ROS production induced by nano-TiO2 and prevented by Fe incorporation. [PDF]
Toxicol Res (Camb), 2019 The potential impact of TiO2 and Fe incorporated TiO2 nanoparticles at the organelle level has been reported. The toxicity of the samples on mitochondria isolated from chicken liver tissue has been examined through mitochondrial swelling, membrane ...
Barkhade T, Mahapatra SK, Banerjee I.
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Mitochondrial Volume Regulation and Swelling Mechanisms in Cardiomyocytes
Antioxidants, 2023 Mitochondrion, known as the “powerhouse” of the cell, regulates ion homeostasis, redox state, cell proliferation and differentiation, and lipid synthesis. The inner mitochondrial membrane (IMM) controls mitochondrial metabolism and function. It possesses
Xavier R. Chapa-Dubocq +3 more
doaj +2 more sources
The Role of Swelling in the Regulation of OPA1-Mediated Mitochondrial Function in the Heart In Vitro
Cells, 2023 Optic atrophy-1 (OPA1) plays a crucial role in the regulation of mitochondria fusion and participates in maintaining the structural integrity of mitochondrial cristae.
Xavier R. Chapa-Dubocq +5 more
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A mathematical model of mitochondrial swelling
BMC Research Notes, 2010 Background The permeabilization of mitochondrial membranes is a decisive event in apoptosis or necrosis culminating in cell death. One fundamental mechanism by which such permeabilization events occur is the calcium-induced mitochondrial permeability ...
Filbir Frank +5 more
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European Journal of Pharmacology, 2014 (−)-Epicatechin (EPI) is cardioprotective in the setting of ischemia/reperfusion (IR) injury and doxycycline (DOX) is known to preserve cardiac structure/function after myocardial infarction (MI).
Diego Romero-Perez +2 more
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