Results 21 to 30 of about 2,545,611 (287)

The mitochondrial permeability transition

, 2007
The mitochondrial permeability transition pore (PTP) is a high conductance channel of the inner membrane whose opening leads to an increase of permeability to solutes with molecular masses up to about 1500 Da, the ‘permeability transition’. This potentially catastrophic event has long been known, yet the molecular bases for its occurrence remain ...
BERNARDI, PAOLO, FORTE M.
openaire   +2 more sources

Transcriptional regulation of cyclophilin D by BMP/Smad signaling and its role in osteogenic differentiation

eLife, 2022
Cyclophilin D (CypD) promotes opening of the mitochondrial permeability transition pore (MPTP) which plays a key role in both cell physiology and pathology.
Rubens Sautchuk, Brianna H Kalicharan, Katherine Escalera-Rivera, Jennifer H Jonason, George A Porter, Hani A Awad, Roman A Eliseev   +6 more
doaj   +1 more source

The Regulation of Non-Specific Membrane Permeability Transition in Yeast Mitochondria under Oxidative Stress

Microbiology Research, 2021
In this study, the mechanism of non-specific membrane permeability (yPTP) in the Endomyces magnusii yeast mitochondria under oxidative stress due to blocking the key antioxidant enzymes has been investigated.
Elena P. Isakova, Olga I. Klein, Yulia I. Deryabina   +2 more
doaj   +1 more source

A Cardiac Mitochondrial FGFR1 Mediates the Antithetical Effects of FGF2 Isoforms on Permeability Transition

Cells, 2021
Mitochondria, abundant organelles in high energy demand cells such as cardiomyocytes, can determine cell death or survival by regulating the opening of mitochondrial permeability transition pore, mPTP.
Wattamon Srisakuldee, Barbara E. Nickel, Robert R. Fandrich, Feixong Zhang, Kishore B. S. Pasumarthi, Elissavet Kardami   +5 more
doaj   +1 more source

Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury

Biomolecules, 2020
Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic ...
Kristina Skemiene, Evelina Rekuviene, Aiste Jekabsone, Paulius Cizas, Ramune Morkuniene, Vilmante Borutaite   +5 more
doaj   +1 more source

The Haves and Have-Nots: The Mitochondrial Permeability Transition Pore across Species

Cells, 2023
The demonstration that F1FO (F)-ATP synthase and adenine nucleotide translocase (ANT) can form Ca2+-activated, high-conductance channels in the inner membrane of mitochondria from a variety of eukaryotes led to renewed interest in the permeability ...
Elena Frigo, Ludovica Tommasin, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +4 more
doaj   +1 more source

Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak

Frontiers in Cell and Developmental Biology, 2021
Mitochondrial permeability transition pore (MPTP)-dependent necrosis contributes to numerous pathologies in the heart, brain, and skeletal muscle. The MPTP is a non-selective pore in the inner mitochondrial membrane that is triggered by high levels of ...
Pooja Patel, Pooja Patel, Arielys Mendoza, Arielys Mendoza, Dexter J. Robichaux, Dexter J. Robichaux, Meng C. Wang, Meng C. Wang, Meng C. Wang, Xander H. T. Wehrens, Xander H. T. Wehrens, Jason Karch, Jason Karch   +12 more
doaj   +1 more source

Atomistic Simulations of the Permeability and Dynamic Transportation Characteristics of Diamond Nanochannels

Nanomaterials, 2022
Through atomistic simulations, this work investigated the permeability of hexagonal diamond nanochannels for NaCl solution. Compared with the multilayer graphene nanochannel (with a nominal channel height of 6.8 Å), the diamond nanochannel exhibited ...
Bingqing Li, Bin Dong, Tianxiang Shi, Haifei Zhan, Yongqiang Zhang   +4 more
doaj   +1 more source

Cyclophilin D-induced mitochondrial impairment confers axonal injury after intracerebral hemorrhage in mice

Neural Regeneration Research, 2023
The mitochondrial permeability transition pore is a nonspecific transmembrane channel. Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling, calcium overload, and axonal degeneration ...
Yang Yang, Kai-Yuan Zhang, Xue-Zhu Chen, Chuan-Yan Yang, Ju Wang, Xue-Jiao Lei, Yu-Lian Quan, Wei-Xiang Chen, Heng-Li Zhao, Li-Kun Yang, Yu-Hai Wang, Yu-Jie Chen, Hua Feng   +12 more
doaj   +1 more source

Increased susceptibility of striatal mitochondria to calcium-induced permeability transition [PDF]

, 2003
Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition.
Brustovetsky, T, Dubinsky, JM, Tatiana Brustovetsky, Janet M. Dubinsky, Capano, M, Purl, KJ, Michela Capano, Martin Crompton, Kevin J. Purl, Brustovetsky, N, Crompton, M, Nickolay Brustovetsky   +11 more
core   +1 more source