Results 101 to 110 of about 2,782,679 (244)

Discrimination between two steps in pore opening during the mitochondrial permeability transition

, 2005
It is well known that a lag phase generally elapses between the addition of inducers of the mitochondrial permeability transition and the opening of the pore.
Nikolov P, Petronilli V, Ricchelli F, Jori G, Gobbo S   +4 more
core   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

CKB Promotes Mitochondrial ATP Production by Suppressing Permeability Transition Pore

Advanced Science
Creatine kinases are essential for maintaining cellular energy balance by facilitating the reversible transfer of a phosphoryl group from ATP to creatine, however, their role in mitochondrial ATP production remains unknown.
Le He, Jianghua Lin, Shaojuan Lu, Hao Li, Jie Chen, Xinyi Wu, Qixin Yan, Hailiang Liu, Hui Li, Yufeng Shi   +9 more
doaj   +1 more source

Darcy to non-Darcy seepage transition in heterogeneous coarse-grained soil: Seepage characteristics and critical threshold prediction

Journal of Rock Mechanics and Geotechnical Engineering
Seepage in coarse-grained soil exhibits distinct non-Darcy characteristics, and the transition from linear to nonlinear seepage significantly affects the hydraulic characteristics and geotechnical applications.
Xin Zhang, Yufeng Wei, Guoxiang Tu, Hao Yang, Shixin Zhang, Peng Liang   +5 more
doaj   +1 more source

Mitochondrial permeability transition pore as a selective target for anti-cancer therapy

Frontiers in Oncology, 2013
Mitochondrial outer membrane permeabilization (MOMP) is the ultimate step in dozens of lethal apoptotic signal transduction pathways which converge on mitochondria.
Dong Hoon eSuh, Mi-Kyung eKim, Hee Seung eKim, Hyun Hoon eChung, Yong Sang eSong, Yong Sang eSong, Yong Sang eSong   +6 more
doaj   +1 more source

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

Advanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares, Nadège Bouchonneau, Christian Jochum, Donald Radford   +3 more
wiley   +1 more source

The Permeability Transition Pore as a Mitochondrial Ca2+ Release Channel; a Critical Appraisal

, 1996
Mitochondria from a variety of sources possess an inner membrane channel, the permeability transition pore. The pore is a voltage-dependent channel, activated by matrix Ca2+ and inhibited by matrix H+, which can be blocked by cyclosporin A, presumably ...
PETRONILLI V., BERNARDI, PAOLO
core   +1 more source

The Mitochondrial Permeability Transition.

, 1998
This review summarizes recent work on the regulation of the permeability transition pore, a cyclosporin A-sensitive mitochondrial channel that may play a role in intracellular calcium homeostasis and in a variety of forms of cell death.
PETRONILLI V., NICOLLI, ANNAMARIA, COSTANTINI, PAOLA, COLONNA R., ICHAS F., BERNARDI, PAOLO, MASSARI S., FONTAINE E., ERIKSSON O., SCORRANO, LUCA   +9 more
core   +1 more source

Shedding light on the mitochondrial permeability transition

, 2011
The mitochondrial permeability transition is an increase of permeability of the inner mitochondrial membrane to ions and solutes with an exclusion size of about 1500 Da.
RICCHELLI F, BERNARDI, PAOLO, SILEIKYTE J, Fernanda Ricchelli, Paolo Bernardi, Justina Šileikytė   +5 more
core   +2 more sources

Self‐Cleaning Sensor Surfaces for Long‐Term Environmental Monitoring

Advanced Engineering Materials, EarlyView.
Long‐term use of unattended outdoor sensors without soiling or biofouling is achieved through generation of a micro‐ and nanorough cuvette surface by combing hydrophobic nanoparticles with fluorinated polymers, crosslinked and surface‐attached through CHic chemistry. The coating demonstrates self‐cleaning behavior and prolonged outdoor stability, which
Sanam Kumari Rajak, Yasmina Frey, Ulrike Wallrabe, Oswald Prucker, Jürgen Rühe   +4 more
wiley   +1 more source