Results 201 to 210 of about 2,782,679 (244)

Human‐Scale Rotating Magnetic Field Delivery With Permanent Magnets Under Anatomic and Robotic Constraints

Advanced Robotics Research, EarlyView.
Rotating magnetic fields (RMFs) are widely used for microrobot propulsion and control. We show that RMF generation with permanent magnets is mechanically feasible for many limb and intracranial applications but becomes constrained for thoracic targets.
Tuan‐Anh Le, Husnu Halid Alabay, Anika Sivarasa, Gia‐Minh Hoang, Hakan Ceylan   +4 more
wiley   +1 more source

Wireless Precise Manipulation of Tumor Spheroids Using a Millirobot Controlled by Permanent Magnetic Traps

Advanced Robotics Research, EarlyView.
A magnetic donut‐like millirobot is developed for label‐free pick‐and‐place of a tumor spheroid wirelessly controlled by a magnetic trap. Spheroids are important 3D multicellular culture systems that recapitulate key structural and functional features of native tissues.
Yue Gao, Moonkwang Jeong, Anni G. Muñoz, Ann‐Sophia Müller, Fangchao Long, Shengqiang Zhou, Juntian Qu, Leoni A. Kunz‐Schughart, Tian Qiu   +8 more
wiley   +1 more source

Dual‐Mode Gripper With Suction and Shape‐Adaptive Freezing Grasps

Advanced Robotics Research, EarlyView.
This study presents a dual‐mode robotic gripper that combines vacuum suction with a shape‐adaptive freezing grasp. The freezing mode uses a compliant rubber membrane, a sprayed water layer, and dry‐ice powder to generate ice‐mediated adhesion while conforming to complex geometries.
Takuma Yanagisawa, Toshihiro Nishimura, Yosuke Suzuki, Tokuo Tsuji, Tetsuyou Watanabe   +4 more
wiley   +1 more source

The mitochondrial permeability transition pore in AD 2016: An update

Biochimica Et Biophysica Acta - Molecular Cell Research, 2016
Over the past 30 years the mitochondrial permeability transition the permeabilization of the inner mitochondrial membrane due to the opening of a wide pore has progressed from being considered a curious artifact induced in isolated mitochondria by Ca2 ...
Mario Zoratti, Michele Azzolini, Ildikó Szabó   +2 more
exaly   +5 more sources

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The mitochondrial permeability transition pore

Biochemical Society Symposia, 1999
This chapter reviews recent advances in the identification of the structural elements of the permeability transition pore. The discovery that cyclosporin A (CsA) inhibits the pore proved instrumental. Various approaches indicate that CsA blocks the pore by binding to cyclophilin (CyP)-D.
M, Crompton, S, Virji, V, Doyle, N, Johnson, J M, Ward   +4 more
openaire   +2 more sources

Genetic Dissection of the Permeability Transition Pore

Journal of Bioenergetics and Biomembranes, 2005
The permeability transition pore (PTP) regulates the structural re-organization of mitochondria in response to changes in cellular Ca(2+) and is thought to be an important participant in mitochondrial responses to cell death signals. Although the proteins forming the PTP have yet to be rigorously identified, recent examination of the response of ...
BERNARDI, PAOLO, FORTE M.
openaire   +2 more sources

The mitochondrial megachannel is the permeability transition pore

Journal of Bioenergetics and Biomembranes, 1992
Single-channel electrophysiological recordings from rat liver mitoplast membranes showed that the 1.3-nS mitochondrial megachannel was activated by Ca++ and inhibited by Mg++, Cyclosporin A, and ADP, probably acting at matrix-side sites. These agents are known to modulate the so-called mitochondrial permeability transition pore (Gunter, T.
SZABO', ILDIKO', Zoratti, M.
openaire   +3 more sources

Tristability in mitochondrial permeability transition pore opening

Chaos: An Interdisciplinary Journal of Nonlinear Science, 2021
Mitochondrial permeability transition pore (PTP), a key regulator of cell life and death processes, is triggered by calcium ions (Ca2+) and potentiated by reactive oxygen species (ROS). Although the two modes of PTP opening, i.e., transient and persistent, have been identified for a long time, its dynamical mechanism is still not fully understood.
Hong Qi, Zhi-Chao Li, Shi-Miao Wang, Lin Wu, Fei Xu, Zhi-Long Liu, Xiang Li, Jia-Zeng Wang   +7 more
openaire   +2 more sources

Mitochondrial permeability transition pore-dependent necrosis

Journal of Molecular and Cellular Cardiology, 2023
Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is triggered by increases in matrix levels of Ca2+ and reactive oxygen species. This form of cell death has been implicated in ischemic injuries of the heart and brain as well
Dexter J, Robichaux, Mikako, Harata, Elizabeth, Murphy, Jason, Karch   +3 more
openaire   +2 more sources

Pharmacology of mitochondrial permeability transition pore inhibitors

Drug Development Research, 2019
AbstractIt is now firmly established that an important event in the formation of reperfusion injury of the heart is the opening of mitochondrial permeability transition pores (mPTPs), which changes the permeability of the mitochondria. mPTP opening results in the death of cardiomyocytes through activation of apoptosis and necroptosis.
Peter Oeltgen, Leonid Maslov, Natalia Naryzhnaya   +2 more
exaly   +3 more sources