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The Mitochondrial Permeability Transition Pore
2018The mitochondrial permeability transition (MPT) consists of an abrupt increase in the permeability of the inner mitochondrial membrane to low molecular weight solutes, resulting in the osmotic breakout of the organelle. MPT drives cell death and provides an etiological contribution to several human disorders characterized by the acute loss of post ...
Morganti, Claudia +8 more
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Permeability Transition Pore Closure Promoted by Quinine
Journal of Bioenergetics and Biomembranes, 1999The mitochondrial membrane permeability transition induced by Ca2+ is inhibited by quinine in a dose-dependent fashion. Competition experiments strongly suggest that quinine displaces Ca2+ bound to the inner membrane. This is supported by experiments showing that quinine inhibits Ca2+-dependent but not Ca2+-independent mitochondrial swelling induced by
R, Catisti, A E, Vercesi
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The permeability transition pore complex: another view
Biochimie, 2002Mitochondria play a critical role in initiating both apoptotic and necrotic cell death. A major player in this process is the mitochondrial permeability transition pore (MPTP), a non-specific pore, permeant to any molecule of < 1.5 kDa, that opens in the inner mitochondrial membrane under conditions of elevated matrix [Ca(2+)], especially when this is ...
Halestrap, AP, Mcstay, GP, Clarke, SJ
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The mitochondrial permeability transition pore.
Novartis Foundation symposium, 2008The mitochondrial permeability transition pore (PTP) is a high conductance channel of the inner membrane whose opening leads to an increase of permeability to solutes with molecular masses up to about 1500Da, the 'permeability transition'. This potentially catastrophic event has long been known, yet the molecular bases for its occurrence remain ...
Paolo, Bernardi, Michael, Forte
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The mitochondrial permeability transition pore as a target for preconditioning and postconditioning
Basic Research in Cardiology, 2009The experimental evidence supporting the mitochondrial permeability transition pore (mPTP) as a major mediator of lethal myocardial reperfusion injury and therefore a critical target for cardioprotection is persuasive. Although, its molecular identity eludes investigators, it is generally accepted that mitochondrial cyclophilin-D, the target for the ...
Derek J, Hausenloy +2 more
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The permeability transition pore as a pathway for the release of mitochondrial DNA
Life Sciences, 2005This study shows that under oxidative stress DNA from liver mitochondria (mtDNA) can be released through the non-specific permeability transition pore. Pore opening was induced after the addition of Fe2+ and hydrogen peroxide, in the presence of calcium ions.
Noemí, García +3 more
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Inactivation of Mitochondrial Permeability Transition Pore by Octylguanidine and Octylamine
Journal of Bioenergetics and Biomembranes, 2000Mitochondrial permeability transition occurs through a Ca2+-dependent opening of a transmembrane pore, whose identity has been attributed to that of the adenine nucleotide translocase (ANT). In this work, we induced permeability transition by adding 0.5 microM carboxyatractyloside.
E, Chávez +5 more
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Mitochondrial Permeability Transition Pore and Calcium Handling
2018The opening of a large conductance channel in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore (PTP), has been shown to be a primary mediator of cell death in the heart subjected to ischemia-reperfusion injury.
Randi J, Parks +2 more
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Lethal and Nonlethal Functions of the Permeability Transition Pore
2016The mitochondrial permeability transition is an inner membrane permeability increase that can be traced to the opening of a specific but nonselective high-conductance inner membrane channel named the permeability transition pore (PTP). PTP can open either transiently or permanently.
Fontaine, Eric, BERNARDI, PAOLO
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What is the mitochondrial permeability transition pore?
Journal of Molecular and Cellular Cardiology, 2009Under conditions of mitochondrial calcium overload, especially when accompanied by oxidative stress, elevated phosphate concentrations and adenine nucleotide depletion, a non-specific pore, the mitochondrial permeability transition pore (MPTP), opens in the inner mitochondrial membrane.
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