Results 61 to 70 of about 11,517 (308)

OXIDATIVE STRESS AND LIPID PEROXIDATION IN THE NEWBORN [PDF]

Pediatric Research, 1994
Increasing appreciation of the causative role of oxidative injury in the development of many severe diseases of the newborn places great importance on the reliable assessment of lipid peroxidation. Lipid peroxidation in the erythrocyte membrane has been widely investigated but little has been reported on lipid peroxidation in the plasma The aim of the ...
Giuseppe Buonocore, Stefano Zani, Maria Angela Farnetant, Franco Bagnoli, Rodolfo Bracci   +4 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Supplementation with Bioactive Compounds Improves Health and Rejuvenates Biological Age in Postmenopausal Women

Biomolecules
Aging involves immune system deterioration (immunosenescence) and increased oxidative stress, both associated with morbidity and mortality. Menopause accelerates aging, highlighting the need for strategies to mitigate its effects in postmenopausal women.
Estefanía Díaz-Del Cerro, Judith Félix, Mª Carmen Martínez-Poyato, Mónica De la Fuente   +3 more
doaj   +1 more source

Analysis of phytochemicals, minerals and in vitro antioxidant activities of Gongronema latifolium leaves [PDF]

, 2017
Gongronema latifolium is primarily used as spice and vegetable as well as a herb in traditional medicine in the treatment of malaria, diabetes and hypertension.
Chinwe, Igwe V., Usunomena, Usunobun
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway

Behavioural Neurology, 2022
The pathogenesis of sepsis-associated encephalopathy (SAE) involves many aspects, including intracellular peroxidative stress damage, mitochondrial dysfunction, and cell apoptosis. In this study, we mainly explored the influence of P2X7R on the cognitive
Kaifang Wang, Meiyan Sun, Zhaodong Juan, Jianxin Zhang, Yingui Sun, Guizhi Wang, Chunling Wang, Yanjing Li, Wenwen Kong, Lulu Fan, Yue Zhang, Hongxiang Zhao, Xiaoyong Zhao   +12 more
doaj   +1 more source

Coordination of the N-Terminal Heme in the Non-Classical Peroxidase from Escherichia coli

Molecules, 2023
The non-classical bacterial peroxidase from Escherichia coli, YhjA, is proposed to deal with peroxidative stress in the periplasm when the bacterium is exposed to anoxic environments, defending it from hydrogen peroxide and allowing it to thrive under ...
Ricardo N. S. Oliveira, Sara R. M. M. de Aguiar, Sofia R. Pauleta   +2 more
doaj   +1 more source

Extra virgin olive oil and cardiovascular diseases: benefits for human health [PDF]

, 2017
The cardioprotective properties of Mediterranean Diet were demonstrated for the first time from the Seven Country Study. In the last few decades, numerous epidemiological studies, as well as intervention trial, confirmed this observation, pointing out ...
Cammisotto, Vittoria, Carnevale, Roberto, Castellani, Valentina, D'Amico, Alessandra, Fianchini, Luca, Nocella, Cristina, Novo, Marta, Stefanini, Lucia, Violi, Francesco   +8 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Oxidative Stress of Human Sperm Cryopreservation

Antioxidants
Due to their negligible cytoplasm and composition of the sperm plasmalemma, spermatozoa are particularly vulnerable to lipid peroxidative damage induced by reactive oxygen species (ROS).
Steven D. Fleming, Laura K. Thomson
doaj   +1 more source