Results 41 to 50 of about 65,477 (305)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Reductive Cleavage of Organic Peroxides by Iron Salts and Thiols [PDF]
, 2018 Despite the low bond strength of the oxygen–oxygen bond, organic peroxides are often surprisingly resistant to cleavage by nucleophiles and reductants. As a result, achieving decomposition under mild conditions can be challenging.
Patrick H. Dussault +14 more
core +1 more source
DFT Benchmark Study of the O--O Bond Dissociation Energy in Peroxides Validated with High-Level Ab-Initio Calculations [PDF]
, 2020 Peroxides play a central role in many chemical and biological pro- cesses such as the Fenton reaction. The relevance of these compounds lies in the low stability of the O–O bond which upon dissociation results in radical species able to initiate various ...
Danilo, Carmona +2 more
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Synthesis, characterization and reactivity of polymeric peroxides
, 1990 Polymeric peroxides constitute an important class of compounds. There are two main groups of these materials: (i) those formed from vinyl monomers and oxygen, and (ii) those formed from aldehydes and ketones by reaction with oxidizing agents such as ...
Kishore, K., Mukundan, T.
core +2 more sources
Neopterin and Oxidation Products in the Blood of Patients with Various Forms of Dementia
Pteridines, 2003 Human monocyte-derived macrophages and dendritic cells produce increased amounts of neopterin derivatives upon stimulation with interferon-γ (IFN-γ).
Frick Barbara +6 more
doaj +1 more source
Atmospheric peroxides. Technical progress report
, 1994 The research conducted in this program has furthered the development of a method for real-time analysis of hydrogen peroxide, methyl hydroperoxide, and hydroxymethyl hydroperoxide, the most abundant peroxides in the atmosphere. The Fenton method was used
Weinstein-Lloyd, J.
core +1 more source
Advances in the synthesis of acyclic peroxides [PDF]
, 2017 Peroxide-containing compounds are an attractive synthetic target, given their widespread abundance in nature, with many displaying potent antimalarial and antimicrobial properties.
H. Gandhi +14 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Rearrangements of organic peroxides and related processes
, 2016 This review is the first to collate and summarize main data on named and unnamed rearrangement reactions of peroxides. It should be noted, that in the chemistry of peroxides two types of processes are considered under the term rearrangements.
Ivan A. Yaremenko +3 more
core +1 more source