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Peroxiredoxins in the Lung with Emphasis on Peroxiredoxin VI
2007All six mammalian peroxiredoxins are expressed in the lung. Peroxiredoxin (Prx) VI is the isoform expressed at the highest level and its lung expression exceeds that for other organs. The predominant location of Prx VI is the cytosol and acidic organelles of Clara cells of the conducting airways and type II epithelial cells and macrophages in the ...
Bruno, Schremmer +3 more
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Annual Review of Plant Biology, 2003
Peroxiredoxins (Prxs) are abundant low-efficiency peroxidases located in distinct cell compartments including the chloroplast and mitochondrion. They are grouped into four clans based on their structural and biochemical properties. The catalytic center contains a cysteinyl residue that reduces diverse peroxides and is regenerated via intramolecular or
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Peroxiredoxins (Prxs) are abundant low-efficiency peroxidases located in distinct cell compartments including the chloroplast and mitochondrion. They are grouped into four clans based on their structural and biochemical properties. The catalytic center contains a cysteinyl residue that reduces diverse peroxides and is regenerated via intramolecular or
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2007
Some members of the Prx family are up-regulated in cells under stress conditions. Prx I is the major cytoplasmic Prx and is known as a stress-inducible antioxidant enzyme. Various stress agents or conditions activate Prx I gene expression in vitro and in vivo.
Tetsuro, Ishii, Toru, Yanagawa
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Some members of the Prx family are up-regulated in cells under stress conditions. Prx I is the major cytoplasmic Prx and is known as a stress-inducible antioxidant enzyme. Various stress agents or conditions activate Prx I gene expression in vitro and in vivo.
Tetsuro, Ishii, Toru, Yanagawa
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Structural Survey of the Peroxiredoxins
2007Peroxiredoxins (Prxs) are ubiquitous proteins that use an active site Cys residue to reduce hydroperoxides. Structural studies since the first Prx structure was determined in 1998 have produced 35 crystal structures of wild type and mutant Prxs with at least one representative structure from each of the five major evolutionary subfamilies of Prxs ...
P Andrew, Karplus, Andrea, Hall
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2000
Abstract The peroxiredoxin family is a widely distributed class of enzymes that directly reduce H2O2 and other hydroperoxides, with hydrogen derived from NAD(P)H, by different routes (1). Two highly conserved cysteine residues are revealed by alignment of the peroxiredoxin family members.
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Abstract The peroxiredoxin family is a widely distributed class of enzymes that directly reduce H2O2 and other hydroperoxides, with hydrogen derived from NAD(P)H, by different routes (1). Two highly conserved cysteine residues are revealed by alignment of the peroxiredoxin family members.
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The Catalytic Mechanism of Peroxiredoxins
2007Peroxiredoxins carry out the efficient reduction of a typically broad range of peroxide substrates through an absolutely conserved, activated cysteine residue within a highly conserved active site pocket structure. Though details of reductive recycling after cysteine sulfenic acid formation at the active site vary among members of different Prx classes,
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Enhanced hyperoxidation of peroxiredoxin 2 and peroxiredoxin 3 in the presence of bicarbonate/CO2
Free Radical Biology and Medicine, 2019Hydrogen peroxide undergoes an equilibrium reaction with bicarbonate/CO2 to produce peroxymonocarbonate (HCO4-). Peroxymonocarbonate is more reactive with thiols than H2O2 but it makes up only a small fraction of the H2O2 in physiological bicarbonate buffers so the increase in rate of oxidation of low molecular weight thiols is modest.
Alexander V, Peskin +2 more
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Peroxiredoxins as biomarkers of oxidative stress
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014Peroxiredoxins (Prxs) are a class of abundant thiol peroxidases that degrade hydroperoxides to water. Prxs are sensitive to oxidation, and it is hypothesized that they also act as redox sensors. The accumulation of oxidized Prxs may indicate disruption of cellular redox homeostasis.This review discusses the biochemical properties of the Prxs that make ...
Rebecca A, Poynton, Mark B, Hampton
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Peroxiredoxin 6 is a natural radioprotector
Doklady Biochemistry and Biophysics, 2016After injection of 20 mg/kg peroxiredoxin 6 to male Kv:SHK mice 15 min before X-ray irradiation in the range of lethal doses (7-10 Gy), the mice remained alive for 30 days, whereas the mortality of the control animals was 100%. In the irradiated animals, peroxiredoxin 6 decreased the severity of radiation-induced leucopenia, granulocytopenia, and ...
M G, Sharapov +8 more
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Targeting peroxiredoxins against leukemia
Experimental Cell Research, 2013Peroxiredoxins (Prx), a family of small non-seleno peroxidases, are important regulators for cellular reactive oxygen species (ROS), which contribute to many signaling pathways and pathogenesis of diseases. Targeting redox homeostasis is being developed as a promising therapeutic strategy for many diseases such as cancers.
Chuan-Xu, Liu +4 more
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