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Redox regulation by sulfiredoxin-1: bridging cysteine oxidation and liver disease therapeutics [PDF]
Experimental and Molecular MedicineCysteine (Cys) posttranslational modifications play a critical role in regulating protein function, cellular signaling and redox homeostasis in various physiological and pathological conditions.
Jong-Won Kim +5 more
doaj +3 more sources
Sulfiredoxin levels in gingival crevicular fluid: A new antioxidant defence system- case control study [PDF]
Journal of Oral Biology and Craniofacial ResearchIntroduction: Periodontitis is a chronic inflammatory condition in which oxidative stress plays a major role in its pathogenesis. The redox balance in the body acts as a defense system to counter this stress.
Disha Dixit +5 more
doaj +3 more sources
Antioxidants, 2023 Non-small cell lung cancer (NSCLC), the most common type of lung cancer, etiologically associates with tobacco smoking which mechanistically contributes to oxidative stress to facilitate the occurrence of mutations, oncogenic transformation and ...
Qiou Wei +2 more
exaly +4 more sources
p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3 [PDF]
Redox Biology, 2022 Mitochondrial dysfunction is a key contributor to necroptosis. We have investigated the contribution of p53, sulfiredoxin, and mitochondrial peroxiredoxin 3 to necroptosis in acute pancreatitis.
Sergio Rius-Pérez +3 more
doaj +3 more sources
Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State
Antioxidants, 2021 Human peroxiredoxins (Prx) are a family of antioxidant enzymes involved in a myriad of cellular functions and diseases. During the reaction with peroxides (e.g., H2O2), the typical 2-Cys Prxs change oligomeric structure between higher order (do)decamers ...
Hanzhi Wu +2 more
exaly +4 more sources
Redox Biology, 2021 Cancer stem cells (CSCs) initiate tumor formation and are known to be resistant to chemotherapy. A metabolic alteration in CSCs plays a critical role in stemness and survival. However, the association between mitochondrial energy metabolism and the redox
Sung-Wuk Jang +2 more
exaly +4 more sources
DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis [PDF]
Redox BiologyGrowing evidence suggests that dimethylarginine dimethylaminohydrolase 1 (DDAH1), a crucial enzyme for the degradation of asymmetric dimethylarginine (ADMA), is closely related to oxidative stress during the development of multiple diseases. However, the
Juntao Yuan +8 more
doaj +3 more sources
Sulfiredoxin stimulates luteinization in vitro by promoting progesterone production in rats. [PDF]
ReproductionIn brief Sulfiredoxin (Srxn1) is essential for corpus luteum formation during ovulation. Inhibition of Srxn1 with J14 suppressed LH-stimulated progesterone production, key gene expressions (Cyp11a1, Star), and markers of luteinization.
Chun SY +4 more
europepmc +2 more sources
Cell Death and Disease, 2021 Acinar cell injury and the inflammatory response are critical bioprocesses of acute pancreatitis (AP). We investigated the role and underlying mechanism of sulfiredoxin-1 (Srxn1) in AP.
Jun He +10 more
doaj +2 more sources
The desulfinylation enzyme sulfiredoxin-1 attenuates HSC activation and liver fibrosis by modulating the PTPN12-NLRP3 axis. [PDF]
HepatologyBackground & Aims: Liver fibrosis is characterized by the progressive scarring of liver tissue. Oxidative stress is a critical causal factor of hepatic stellate cell (HSC) activation and the subsequent liver fibrogenesis, but the mechanism is not fully ...
Kim JW +13 more
europepmc +2 more sources