p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3 [PDF]
Redox Biology, 2022 Mitochondrial dysfunction is a key contributor to necroptosis. We have investigated the contribution of p53, sulfiredoxin, and mitochondrial peroxiredoxin 3 to necroptosis in acute pancreatitis.
Sergio Rius-Pérez +3 more
doaj +2 more sources
Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State
Antioxidants, 2021 Human peroxiredoxins (Prx) are a family of antioxidant enzymes involved in a myriad of cellular functions and diseases. During the reaction with peroxides (e.g., H2O2), the typical 2-Cys Prxs change oligomeric structure between higher order (do)decamers ...
Tom E Forshaw +2 more
exaly +3 more sources
Antioxidants, 2023 Non-small cell lung cancer (NSCLC), the most common type of lung cancer, etiologically associates with tobacco smoking which mechanistically contributes to oxidative stress to facilitate the occurrence of mutations, oncogenic transformation and ...
Pratik Thapa +2 more
exaly +3 more sources
Nrf2/HO-1-sulfiredoxin1 pathway involved in nanobubble hydrogen-dissolved water-mediated protective effects by ultrasound-guided early local injection in a rat model of chronic constriction injury-induced neuropathic pain [PDF]
Frontiers in Molecular NeuroscienceIntroductionNeuropathic pain (NP) is a kind of common and intractable chronic pain. Hydrogen (H2)-rich water exhibited protective effects in NP by intrathecal injection, drinking, and intraperitoneal injection.
Junmin Yu +4 more
doaj +2 more sources
Sulfiredoxin levels in gingival crevicular fluid: A new antioxidant defence system- case control study [PDF]
Journal of Oral Biology and Craniofacial ResearchIntroduction: Periodontitis is a chronic inflammatory condition in which oxidative stress plays a major role in its pathogenesis. The redox balance in the body acts as a defense system to counter this stress.
Disha Dixit +5 more
doaj +2 more sources
Redox regulation by sulfiredoxin-1: bridging cysteine oxidation and liver disease therapeutics [PDF]
Experimental and Molecular MedicineCysteine (Cys) posttranslational modifications play a critical role in regulating protein function, cellular signaling and redox homeostasis in various physiological and pathological conditions.
Jong-Won Kim +5 more
doaj +2 more sources
Association of SRXN1 receptor gene polymorphism with susceptibility to periodontitis [PDF]
Contemporary Clinical Dentistry, 2022 Background: Emerging evidence suggests that oxidative stress forms a key component in the etiopathogenesis of periodontitis. Literature evidence have shown potential antioxidants responsible for combating the pro-oxidants which stress the periodontium ...
Karthikeyan Murthykumar +2 more
doaj +2 more sources
Inhibition of NOX2 or NLRP3 inflammasome prevents cardiac remote ischemic preconditioning [PDF]
Frontiers in Physiology, 2023 Introduction: Short episodes of ischemia-reperfusion (IR) in the heart (classical ischemic preconditioning, IPC) or in a limb (remote ischemic preconditioning, RIPC) before a prolonged ischemic episode, reduce the size of the infarct.
Sandra Benavides +7 more
doaj +2 more sources
Role of sulfiredoxin in systemic diseases influenced by oxidative stress
Redox Biology, 2014 Sulfiredoxin is a recently discovered member of the oxidoreductases family which plays a crucial role in thiol homoeostasis when under oxidative stress.
Sheeja S Varghese
exaly +3 more sources
Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline [version 2; peer review: 2 approved] [PDF]
F1000Research, 2022 Introduction: Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress.
Bogdan Ovidiu Popescu +8 more
doaj +2 more sources