Results 21 to 30 of about 2,318 (179)

Linoleic Hydroperoxides Are Potent Hyperoxidative Agents of Sensitive and Robust Typical 2-Cys Peroxiredoxins [PDF]

Antioxidants
Typical 2-Cys peroxiredoxins (2-Cys Prxs, AhpC/Prx1 subfamily) are ubiquitous thiol peroxidases that efficiently reduce H2O2 and other hydroperoxides via a reactive peroxidatic Cys (CP).
Vitória Isabela Montanhero Cabrera, Sabrina Vargas, Nathália Miranda de Medeiros, Gabrielle Nascimento Sividanes, Laura Fernandes da Silva, Larissa Regina Diniz, Thiago Geronimo Pires Alegria, João Henrique Ghilardi Lago, Marcos Hikari Toyama, Sayuri Miyamoto, Daniela Ramos Truzzi, Luis Eduardo Soares Netto, Marcos Antonio de Oliveira   +12 more
doaj   +2 more sources

Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer

Oxidative Medicine and Cellular Longevity, 2020
The incidence of prostate cancer (PCa) is increasing, and it is currently the second most frequent cause of death by cancer in men. Despite advancements in cancer therapies, new therapeutic approaches are still needed for treatment-refractory advanced ...
C. N. Barquilha, N. J. Santos, Caio C D Monção, Isabela C Barbosa, F. O. Lima, L. A. Justulin, N. Pértega-Gomes, S. Felisbino   +7 more
semanticscholar   +5 more sources

Sulfiredoxin May Promote Cervical Cancer Metastasis via Wnt/β-Catenin Signaling Pathway

International Journal of Molecular Sciences, 2017
The abnormal elevation of sulfiredoxin (Srx/SRXN1)—an antioxidant enzyme whose main function is to protect against oxidative stress—has been shown to be closely correlated with the progression of several types of cancer, including human cervical cancer ...
K. Lan, Yuni Zhao, Yue Fan, Binbin Ma, Shan-Shan Yang, Qin Liu, H. Linghu, Hui Wang   +7 more
exaly   +2 more sources

Frugoside Induces Mitochondria-Mediated Apoptotic Cell Death through Inhibition of Sulfiredoxin Expression in Melanoma Cells

Cancers, 2019
Malignant melanoma is the most life-threatening neoplasm of the skin. Despite the increase in incidence, melanoma is becoming more resistant to current therapeutic agents. The bioactive compound frugoside has been recently reported to inhibit growth when
Sung-Wuk Jang, Yu Jeong Jeong
exaly   +2 more sources

Effects of cold water immersion versus active recovery on oxidative stress, redox gene expression and mitochondrial adaptations after strength training. [PDF]

Exp Physiol
Abstract We compared the acute and chronic effects of postexercise cold water immersion (CWI) and active recovery (ACT) on oxidative stress, redox‐related gene expression, mitochondrial adaptations and muscle oxidative capacity. In a crossover study, nine males completed strength sessions, followed by either 10 min CWI or ACT.
Roberts LA, Pileggi CA, Zeng N, Figueiredo VC, Markworth JF, Raastad T, Briskey D, Suzuki K, Coombes JS, Cameron-Smith D, Peake JM.   +10 more
europepmc   +2 more sources

Fibulin-1 Improves Caerulein-Induced Acute Pancreatitis In Vitro by Inhibiting Ferroptosis. [PDF]

J Biochem Mol Toxicol
FBLN1 exhibited lower expression in acute pancreatitis. Moreover, FBLN1 inhibited inflammatory injury and ferroptosis in Caerulein‐triggered AR42J cells. FBLN1 can activate the NRF2/HO‐1 pathway. ABSTRACT Acute pancreatitis is an inflammatory disease of the pancreas that is often accompanied by various complications, which seriously impair patient ...
Mai X, He S, Li Y, Zhang L, Xu Q, Wen Y.
europepmc   +2 more sources

Hyperoxidation of Peroxiredoxins and Effects on Physiology of Drosophila

Antioxidants, 2021
The catalytic activity of peroxiredoxins (Prx) is determined by the conserved peroxidatic cysteine (CysP), which reacts with peroxides to form sulfenic acid (Cys-SOH).
Austin McGinnis, Vladimir I. Klichko, William C. Orr, Svetlana N. Radyuk   +3 more
doaj   +1 more source

Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded-Hypertensive Diabetic Db/Db Mice. [PDF]

FASEB Bioadv
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Shahzad Z, Bala N, Illyas A, Kazory A, Chandrasekar I, Alli AA.   +5 more
europepmc   +2 more sources

Loss of Peroxiredoxin IV Protects Mice from Azoxymethane/Dextran Sulfate Sodium-Induced Colorectal Cancer Development

Antioxidants, 2023
Peroxiredoxin IV (Prx4), a typical two-cysteine-containing member of the peroxidase family, functions as an antioxidant to maintain cellular redox homeostasis through the reduction of reactive oxygen species (ROS) via cycles of oxidation–reduction ...
Pratik Thapa, Hong Jiang, Na Ding, Yanning Hao, Aziza Alshahrani, Eun Y. Lee, Junichi Fujii, Qiou Wei   +7 more
doaj   +1 more source

Circadian Oscillation of Sulfiredoxin in the Mitochondria [PDF]

Molecular Cell, 2015
Hydrogen peroxide (H2O2) released from mitochondria regulates various cell signaling pathways. Given that H2O2-eliminating enzymes such as peroxiredoxin III (PrxIII) are abundant in mitochondria, however, it has remained unknown how such release can occur.
Kil, In Sup, Ryu, Keun Woo, Lee, Se Kyoung, Kim, Jeong Yeon, Chu, Sei Yoon, Kim, Ju Hee, Park, Sunjoo, Rhee, Sue Goo   +7 more
openaire   +3 more sources