Results 31 to 40 of about 2,318 (179)
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on SRXN1 (sulfiredoxin 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Chawsheen, HA, Jiang, H, Wei, Q
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A Novel Role for Human Sulfiredoxin in the Reversal of Glutathionylation [PDF]
Cancer Research, 2006 Abstract Modification of protein cysteine residues by disulfide formation with glutathione (glutathionylation) is a reversible posttranslational modification of critical importance in controlling cell signaling events following oxidative and/or nitrosative stress.
Victoria J, Findlay +5 more
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mLife, 2022 Cryptococcus neoformans and its sister species Cryptococcus deuterogattii are important human fungal pathogens. Despite their phylogenetically close relationship, these two Cryptococcus pathogens are greatly different in their clinical characteristics ...
Weixin Ke +11 more
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Catalytic Mechanism of Sulfiredoxin from Saccharomyces cerevisiae Passes through an Oxidized Disulfide Sulfiredoxin Intermediate That Is Reduced by Thioredoxin [PDF]
Journal of Biological Chemistry, 2009 Sulfiredoxin catalyzes the ATP-dependent reduction of overoxidized eukaryotic 2-Cys peroxiredoxin PrxSO(2) into sulfenic PrxSOH. Recent mechanistic studies on sulfiredoxins have validated a catalytic mechanism that includes formation of a phosphoryl intermediate on the sulfinyl moiety of PrxSO(2), followed by an attack of the catalytic cysteine of ...
Roussel, Xavier +4 more
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Antioxidants, 2023 The role of catechins in the epigenetic regulation of gene expression has been widely studied; however, if and how this phenomenon relates to the redox properties of these polyphenols remains unknown.
Patrycja Jakubek +8 more
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Neurobiology of Disease, 2012 In current study, we tested the hypothesis that c-Jun-dependent sulfiredoxin expression mediates protective effects of brain-derived neurotrophic factor (BDNF) against neurotoxicity induced by 3-nitropropionic acid (3-NP), a mitochondrial complex II ...
Chia-Lin Wu +5 more
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Oxidative post-translational modifications of plant antioxidant systems under environmental stress. [PDF]
Physiol PlantAbstract Plants are often subject to environmental challenges posed by abiotic and biotic stresses, which are increasing under the current climate change conditions, provoking a loss in crop yield worldwide. Plants must cope with adverse situations such as increasing temperatures, air pollution or loss of agricultural land due to salinity, drought ...
Jiménez A, Martí MC, Sevilla F.
europepmc +2 more sources
Deglutathionylation of 2-Cys Peroxiredoxin Is Specifically Catalyzed by Sulfiredoxin [PDF]
Journal of Biological Chemistry, 2009 Reversible protein glutathionylation plays a key role in cellular regulation and cell signaling and protects protein thiols from hyperoxidation. Sulfiredoxin (Srx), an enzyme that catalyzes the reduction of Cys-sulfinic acid derivatives of 2-Cys peroxiredoxins (2-Cys Prxs), has been shown to catalyze the deglutathionylation of actin.
Ji Won, Park +3 more
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F1000Research, 2022 Introduction: Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress.
Bogdan Ovidiu Popescu +8 more
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Oxidative Medicine and Cellular Longevity, 2022 Cutaneous squamous cell carcinoma (cSCC) is the second carcinoma in nonmelanoma skin cancer (NMSC). Sulfiredoxin (Srx) is an antioxidant protein with a role in maintaining redox homeostasis. And Srx has an oncogenic role in skin tumorigenesis.
Wen-Hua Wang +6 more
semanticscholar +1 more source