Role of sulfiredoxin in systemic diseases influenced by oxidative stress
Redox Biology, 2014 Sulfiredoxin is a recently discovered member of the oxidoreductases family which plays a crucial role in thiol homoeostasis when under oxidative stress.
Sheeja S. Varghese
exaly +5 more sources
Sulfiredoxin‐1 is a promising novel prognostic biomarker for hepatocellular carcinoma [PDF]
Cancer Medicine, 2020 Identifying novel prognostic biomarkers for hepatocellular carcinoma (HCC) and then, develop an effective individualized treatment strategy remain extremely warranted.
Qian‐Wen Rao +8 more
doaj +4 more sources
Nrf2/HO-1-sulfiredoxin1 pathway involved in nanobubble hydrogen-dissolved water-mediated protective effects by ultrasound-guided early local injection in a rat model of chronic constriction injury-induced neuropathic pain [PDF]
Frontiers in Molecular NeuroscienceIntroductionNeuropathic pain (NP) is a kind of common and intractable chronic pain. Hydrogen (H2)-rich water exhibited protective effects in NP by intrathecal injection, drinking, and intraperitoneal injection.
Junmin Yu +4 more
doaj +2 more sources
New insights on the differential interaction of sulfiredoxin with members of the peroxiredoxin family revealed by protein-protein docking and experimental studies. [PDF]
Eur J Pharmacol, 2023 Sulfiredoxin (Srx) is the enzyme that restores the peroxidase activity of peroxiredoxins (Prxs) through catalyzing the reduction of hyperoxidized Prxs back to their active forms.
Mishra M, Jiang H, Wei Q.
europepmc +2 more sources
A novel role of the fission yeast sulfiredoxin Srx1 in heme acquisition
Molecular Microbiology, 2023 The transporter Str3 promotes heme import in Schizosaccharomyces pombe cells that lack the heme receptor Shu1 and are deficient in heme biosynthesis. Under microaerobic conditions, the peroxiredoxin Tpx1 acts as a heme scavenger within the Str3‐dependent
Tobias Vahsen +3 more
semanticscholar +3 more sources
Dental HypothesesIntroduction: We aimed to determine the association between salivary levels of heme oxygenase 1 (HO-1) and sulfiredoxin-1 (SRXN-1) with periodontal health in smokers and nonsmokers.
Tamara A. Mohammmed, Omar Husham Ali
doaj +2 more sources
Association of SRXN1 receptor gene polymorphism with susceptibility to periodontitis [PDF]
Contemporary Clinical Dentistry, 2022 Background: Emerging evidence suggests that oxidative stress forms a key component in the etiopathogenesis of periodontitis. Literature evidence have shown potential antioxidants responsible for combating the pro-oxidants which stress the periodontium ...
Karthikeyan Murthykumar +2 more
doaj +2 more sources
Inhibition of NOX2 or NLRP3 inflammasome prevents cardiac remote ischemic preconditioning [PDF]
Frontiers in Physiology, 2023 Introduction: Short episodes of ischemia-reperfusion (IR) in the heart (classical ischemic preconditioning, IPC) or in a limb (remote ischemic preconditioning, RIPC) before a prolonged ischemic episode, reduce the size of the infarct.
Sandra Benavides +7 more
doaj +2 more sources
Tumor Biology, 2017 Sulfiredoxin (Srx), a novel oxidative stress-induced antioxidant protein, has been reported to be expressed in several human tumour tissues. However, the expression and functions of Srx in cervical squamous cell carcinoma remain unknown.
Xiaoyan Chen +4 more
exaly +2 more sources
Altered NRF2 signalling in systemic redox imbalance: Insights from non-communicable diseases [PDF]
Redox BiologyThe balanced activity of the cytoprotective transcription factor NRF2 is central for maintaining redox, metabolic-energetics, and proteome homeostasis, as well as for regulating inflammatory responses, among other functions.
Monika Jakubowska +13 more
doaj +2 more sources