Sulfiredoxin‐1 is a promising novel prognostic biomarker for hepatocellular carcinoma [PDF]
Cancer Medicine, 2020 Identifying novel prognostic biomarkers for hepatocellular carcinoma (HCC) and then, develop an effective individualized treatment strategy remain extremely warranted.
Qian‐Wen Rao +8 more
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Redox Biology, 2021 Cancer stem cells (CSCs) initiate tumor formation and are known to be resistant to chemotherapy. A metabolic alteration in CSCs plays a critical role in stemness and survival. However, the association between mitochondrial energy metabolism and the redox
In-Sung Song +2 more
exaly +3 more sources
Oxidative post-translational modifications of plant antioxidant systems under environmental stress. [PDF]
Physiol PlantAbstract Plants are often subject to environmental challenges posed by abiotic and biotic stresses, which are increasing under the current climate change conditions, provoking a loss in crop yield worldwide. Plants must cope with adverse situations such as increasing temperatures, air pollution or loss of agricultural land due to salinity, drought ...
Jiménez A, Martí MC, Sevilla F.
europepmc +2 more sources
Altered NRF2 signalling in systemic redox imbalance: Insights from non-communicable diseases [PDF]
Redox BiologyThe balanced activity of the cytoprotective transcription factor NRF2 is central for maintaining redox, metabolic-energetics, and proteome homeostasis, as well as for regulating inflammatory responses, among other functions.
Monika Jakubowska +13 more
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Linoleic Hydroperoxides Are Potent Hyperoxidative Agents of Sensitive and Robust Typical 2-Cys Peroxiredoxins [PDF]
AntioxidantsTypical 2-Cys peroxiredoxins (2-Cys Prxs, AhpC/Prx1 subfamily) are ubiquitous thiol peroxidases that efficiently reduce H2O2 and other hydroperoxides via a reactive peroxidatic Cys (CP).
Vitória Isabela Montanhero Cabrera +12 more
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Tumor Biology, 2017 Sulfiredoxin (Srx), a novel oxidative stress-induced antioxidant protein, has been reported to be expressed in several human tumour tissues. However, the expression and functions of Srx in cervical squamous cell carcinoma remain unknown.
Xiaoyan Chen +4 more
exaly +2 more sources
Srxn1 Overexpression Protect Against Cardiac Remodelling by Inhibiting Oxidative Stress and Inflammation. [PDF]
J Cell Mol MedABSTRACT Oxidative stress and inflammation are common medical issues contributing to the onset and progression of heart failure (HF). Sulfiredoxin 1 (Srxn1) is a key regulatory factor in the antioxidant response. This study aimed to examine the effect of Srxn1 in HF.
Wang H +6 more
europepmc +2 more sources
DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis [PDF]
Redox BiologyGrowing evidence suggests that dimethylarginine dimethylaminohydrolase 1 (DDAH1), a crucial enzyme for the degradation of asymmetric dimethylarginine (ADMA), is closely related to oxidative stress during the development of multiple diseases. However, the
Juntao Yuan +8 more
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Sulfiredoxin stimulates luteinization in vitro by promoting progesterone production in rats. [PDF]
ReproductionIn brief Sulfiredoxin (Srxn1) is essential for corpus luteum formation during ovulation. Inhibition of Srxn1 with J14 suppressed LH-stimulated progesterone production, key gene expressions ( Cyp11a1 ,
Chun SY +4 more
europepmc +4 more sources
Hyperoxidation of Peroxiredoxins and Effects on Physiology of Drosophila
Antioxidants, 2021 The catalytic activity of peroxiredoxins (Prx) is determined by the conserved peroxidatic cysteine (CysP), which reacts with peroxides to form sulfenic acid (Cys-SOH).
Austin McGinnis +3 more
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