Results 41 to 50 of about 1,937 (151)

Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis [PDF]

Carcinogenesis, 2014
Sulfiredoxin (Srx), the exclusive enzyme that reduces the hyperoxidized inactive form of peroxiredoxins (Prxs), has been found highly expressed in several types of human skin cancer. To determine whether Srx contributed to skin tumorigenesis in vivo, Srx null mice were generated on an FVB background.
Lisha, Wu, Hong, Jiang, Hedy A, Chawsheen, Murli, Mishra, Matthew R, Young, Matthieu, Gerard, Michel B, Toledano, Nancy H, Colburn, Qiou, Wei   +8 more
openaire   +2 more sources

Candida albicans resistance to hypochlorous acid

mBio, 2023
Innate immune cells, especially neutrophils, play key roles in protecting against infection by Candida albicans and other fungal pathogens. A distinct aspect of neutrophils compared to other phagocytes is that they make much higher levels of ...
Lois M. Douglas, Kyunghun Min, James B. Konopka   +2 more
doaj   +1 more source

Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer

Oxidative Medicine and Cellular Longevity, 2020
The incidence of prostate cancer (PCa) is increasing, and it is currently the second most frequent cause of death by cancer in men. Despite advancements in cancer therapies, new therapeutic approaches are still needed for treatment-refractory advanced metastatic PCa.
Caroline N. Barquilha, Nilton J. Santos, Caio C. D. Monção, Isabela C. Barbosa, Flávio O. Lima, Luis A. Justulin, Nelma Pértega-Gomes, Sérgio L. Felisbino   +7 more
openaire   +4 more sources

Nrf2-activated expression of sulfiredoxin contributes to urethane-induced lung tumorigenesis [PDF]

Cancer Letters, 2018
Lung cancer is the leading cause of cancer death worldwide. Cigarette smoking and exposure to chemical carcinogens are among the risk factors of lung tumorigenesis. In this study, we found that cigarette smoke condensate and urethane significantly stimulated the expression of sulfiredoxin (Srx) at the transcript and protein levels in cultured normal ...
Murli Mishra, Hong Jiang, Hedy A. Chawsheen, Matthieu Gerard, Michel B. Toledano, Qiou Wei   +5 more
openaire   +3 more sources

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Drone‐imaging assisted genome‐wide association studies reveal key quantitative trait loci for emergence and late blight resistance in tetraploid potato

Crop Science, Volume 66, Issue 2, March/April 2026.
Abstract Solanum tuberosum L. (potato) is the world's most important vegetable crop, and developing improved cultivars is paramount for global food security. The efficacy of the genomic prediction models that accelerate breeding and genome‐wide association studies (GWAS) depends on large, high‐quality phenotypic datasets, which are often associated ...
Trine Aalborg, Mathias Timmermann Christiansen, Hélène Romé, Aakash Chawade, Merethe Bagge, Kåre Lehmann Nielsen   +5 more
wiley   +1 more source

Characterization of plant sulfiredoxin and role of sulphinic form of 2-Cys peroxiredoxin [PDF]

Journal of Experimental Botany, 2010
The antioxidant function of 2-Cys peroxiredoxin (Prx) involves the oxidation of its conserved peroxidatic cysteine to sulphenic acid that is recycled by a reductor agent. In conditions of oxidative stress, the peroxidatic cysteine can be overoxidized to sulphinic acid inactivating the Prx.
Iglesias-Baena, Iván, Barranco-Medina, Sergio, Lázaro-Payo, Alfonso, López-Jaramillo, Francisco Javier, Sevilla, Francisca, Lázaro, Juan-José   +5 more
openaire   +2 more sources

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2 [PDF]

Epigenetics, 2009
Peroxiredoxins are neuroprotective antioxidant enzymes that reduce hydroperoxides and protect neurons against oxidative stress. However, they can be inactivated through hyperoxidation of their active site cysteine, an event that can take place in the brain in response to oxidative insults such as stroke and also normal aging. Synaptic activity promotes
Soriano, F. X., Papadia, S., Bell, F. S., Hardingham, G. E.; id_orcid 0000-0002-7629-5314   +3 more
openaire   +3 more sources

Cellular Coordination of Transcription Factors and Regulatory Genes for Cryptococcal Virulence

Cellular Microbiology, Volume 2026, Issue 1, 2026.
Cryptococcus neoformans is an opportunistic pathogen belonging to the family Cryptococcaceae, capable of causing systemic and invasive fungal infections in humans and animals. The infection caused by Cryptococcus is lethal primarily in immunocompromised individuals due to the overwhelming expression of virulence factors that drive cryptococcosis in ...
Olufemi S. Folorunso, Olihile M. Sebolai, Sanket Kaushik   +2 more
wiley   +1 more source