Results 61 to 70 of about 2,318 (179)

Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2 [PDF]

Epigenetics, 2009
Peroxiredoxins are neuroprotective antioxidant enzymes that reduce hydroperoxides and protect neurons against oxidative stress. However, they can be inactivated through hyperoxidation of their active site cysteine, an event that can take place in the brain in response to oxidative insults such as stroke and also normal aging. Synaptic activity promotes
Soriano, F. X., Papadia, S., Bell, F. S., Hardingham, G. E.; id_orcid 0000-0002-7629-5314   +3 more
openaire   +3 more sources

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins [PDF]

Journal of Biological Chemistry, 2005
Cysteine residues of certain peroxiredoxins (Prxs) undergo reversible oxidation to sulfinic acid (Cys-SO2H) and the reduction reaction is catalyzed by sulfiredoxin (Srx). Specific Cys residues of various other proteins are also oxidized to sulfinic acid, suggesting that formation of Cys-SO2H might be a novel posttranslational modification that ...
Hyun Ae, Woo, Woojin, Jeong, Tong-Shin, Chang, Kwang Joo, Park, Sung Jun, Park, Jeong Soo, Yang, Sue Goo, Rhee   +6 more
openaire   +2 more sources

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Characterization of plant sulfiredoxin and role of sulphinic form of 2-Cys peroxiredoxin [PDF]

Journal of Experimental Botany, 2010
The antioxidant function of 2-Cys peroxiredoxin (Prx) involves the oxidation of its conserved peroxidatic cysteine to sulphenic acid that is recycled by a reductor agent. In conditions of oxidative stress, the peroxidatic cysteine can be overoxidized to sulphinic acid inactivating the Prx.
Iglesias-Baena, Iván, Barranco-Medina, Sergio, Lázaro-Payo, Alfonso, López-Jaramillo, Francisco Javier, Sevilla, Francisca, Lázaro, Juan-José   +5 more
openaire   +2 more sources

Balancing anti-inflammatory and anti-oxidant responses in murine bone marrow derived macrophages.

PLoS ONE, 2017
RationaleThe underlying pathophysiology of bronchopulmonary dysplasia includes a macrophage-mediated host response orchestrated by anti-inflammatory peroxisome proliferator-activated receptor gamma (PPARγ) and anti-oxidant nuclear factor (erythroid ...
Christopher R Nitkin, Tracey L Bonfield
doaj   +1 more source

Comparative Evaluation of Gingival Crevicular Fluid Sulfiredoxin Levels in Patients with Periodontitis Prior and after Periodontal Therapy: A Prospective Clinical Trial

World Journal of Dentistry
1][12] Bone resorption, resulting in alveolar bone loss and eventual tooth IntroductIonChronic periodontitis (CP) is a persistent inflammatory condition influenced by the complex interaction between the host and oral microbes, damaging the periodontal ...
Sheeja Varghese, M. Karobari, Selvaraj Jayaraman, D. Ganapathy, K. Kumar   +4 more
semanticscholar   +1 more source

Drone‐imaging assisted genome‐wide association studies reveal key quantitative trait loci for emergence and late blight resistance in tetraploid potato

Crop Science, Volume 66, Issue 2, March/April 2026.
Abstract Solanum tuberosum L. (potato) is the world's most important vegetable crop, and developing improved cultivars is paramount for global food security. The efficacy of the genomic prediction models that accelerate breeding and genome‐wide association studies (GWAS) depends on large, high‐quality phenotypic datasets, which are often associated ...
Trine Aalborg, Mathias Timmermann Christiansen, Hélène Romé, Aakash Chawade, Merethe Bagge, Kåre Lehmann Nielsen   +5 more
wiley   +1 more source

Bacteroides fragilis Enterotoxin Induces Sulfiredoxin-1 Expression in Intestinal Epithelial Cell Lines Through a Mitogen-Activated Protein Kinases- and Nrf2-Dependent Pathway, Leading to the Suppression of Apoptosis

International Journal of Molecular Sciences, 2020
Enterotoxigenic Bacteroides fragilis is a causative agent of colitis and secrets enterotoxin (BFT), leading to the disease. Sulfiredoxin (Srx)-1 serves to protect from oxidative damages.
J. Jeon, Jun-Ho Choi, Keun-Hwa Lee, J. Kim   +3 more
semanticscholar   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source