Results 81 to 90 of about 2,318 (179)

Sulfiredoxin is Regulated by NRF2 During Oxidative Stress in Lungs

The FASEB Journal, 2008
Mammalian sulfiredoxin (SRX) plays a role in the regulation of oxidative stress. However, the transcriptional regulation of SRX in response to oxidative stress is not clear. Here we demonstrated that NRF2 transcription factor regulates SRX expression following oxidative stress in lungs. In response to cigarette smoke exposure, lungs from wild‐type mice
Guoyu Ling, Thomas E Sussan, Rajesh K Thimmulappa, Shyam Biswal   +3 more
openaire   +1 more source

Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III [PDF]

Journal of Biological Chemistry, 2009
The mitochondria are the major intracellular source of reactive oxygen species (ROS), which are generated during cellular respiration. The role of peroxiredoxin (Prx) III, a 2-Cys Prx family member, in the scavenging of mitochondrial H(2)O(2) has recently been emphasized.
You Hyun, Noh, Jin Young, Baek, Woojin, Jeong, Sue Goo, Rhee, Tong-Shin, Chang   +4 more
openaire   +2 more sources

Proteomic analysis across aged tissues reveals distinct signatures and the crucial involvement of midgut barrier function in the regulation of aging

Aging Cell, Volume 24, Issue 1, January 2025.
Proteomic analysis reveals that instead of specific proteins, different tissues exhibit common dysregulated functional networks. Specifically, the integrity of the midgut barrier function is compromised during aging, which can be restored through the downregulation of the insulin receptor (InR).
Congying Zhang, Jinlong Wang, Tianzhao Yao, Jiaxin Hu, Feifei Sun, Chunlu Feng, Zhendong Sun, Yuzhuo Shao, Zhu Wang, Jiarui Wu, Yunpeng Huang   +10 more
wiley   +1 more source

CRL3Keap1 E3 ligase facilitates ubiquitin-mediated degradation of oncogenic SRX to suppress colorectal cancer progression

Nature Communications
The antioxidant protein sulfiredoxin-1 (SRX) is an oncogenic factor that promotes tumor progression, but the regulatory mechanism underlying SRX degradation remains to be understood.
Feng Zhu, Liangshan Li, Yuanyuan Chen, Yongfu Pan, Wenjuan Zhang, Lihui Li, Lili Cai, Xiaoxue Zhao, Hu Zhao, Shiwen Wang, Lijun Jia   +10 more
doaj   +1 more source

Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin – Thioredoxin system. 1. Understanding commonalities and differences among cell types

Redox Biology, 2018
The system (PTTRS) formed by typical 2-Cys peroxiredoxins (Prx), thioredoxin (Trx), Trx reductase (TrxR), and sulfiredoxin (Srx) is central in antioxidant protection and redox signaling in the cytoplasm of eukaryotic cells.
Gianluca Selvaggio, Pedro M.B.M. Coelho, Armindo Salvador   +2 more
doaj   +1 more source

Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine

Redox Biology, 2014
Thioredoxin reductase (TR) catalyzes the reduction of thioredoxin (TRX), which in turn reduces mammalian typical 2-Cys peroxiredoxins (PRXs 1–4), thiol peroxidases implicated in redox homeostasis and cell signaling.
Brian Cunniff, Gregg W. Snider, Nicholas Fredette, Jason Stumpff, Robert J. Hondal, Nicholas H. Heintz   +5 more
doaj   +1 more source

Perception and processing of stress signals by plant mitochondria

The Plant Journal, Volume 120, Issue 6, Page 2337-2355, December 2024.
Significance Statement Besides their role in energy metabolism, plant mitochondria have emerged as highly dynamic signalling hubs that integrate external stimuli to coordinate numerous cellular processes including responses to environmental stress. In this review, we provide an overview of the current knowledge on perception and processing of stress ...
Jennifer Selinski, Stephanie Frings, Romy Schmidt‐Schippers   +2 more
wiley   +1 more source

QTL Mapping of Melampsora Leaf Rust Resistance and Yield Component Traits in the Salix F1 Hybrid Common Parent Population

GCB Bioenergy, Volume 16, Issue 10, October 2024.
Pedigrees of the Salix F1 hybrid common parent (HCP) mapping populations. The Salix F1 HCP was comprised of two half‐sib families, both with a S. purpurea common parent and each consisting of four F1 families. Reciprocal crosses were made with male and female S. viminalis and S. suchowensis while S. integra, S. udensis, and S.
Dustin G. Wilkerson, Chase R. Crowell, Christine D. Smart, Lawrence B. Smart   +3 more
wiley   +1 more source

The redox regulator sulfiredoxin forms a complex with thioredoxin domain–containing 5 protein in response to ER stress in lung cancer cells

Journal of Biological Chemistry, 2019
Sulfiredoxin (Srx) reduces hyperoxidized 2-cysteine–containing peroxiredoxins (Prxs) and protects cells against oxidative stress. Previous studies have shown that Srx is highly expressed in primary specimens of lung cancer patients and plays a pivotal ...
Hedy A. Chawsheen, Hong Jiang, Qi Ying, Na Ding, Pratik Thapa, Q. Wei   +5 more
semanticscholar   +1 more source

Nrf2 as a regulator of energy metabolism and mitochondrial function

FEBS Letters, Volume 598, Issue 17, Page 2092-2105, September 2024.
Nrf2 activates the expression of many genes involved in intermediary metabolic pathways such as glycolysis, the pentose phosphate pathway, fatty acid oxidation, and glutaminolysis. Nrf2 also modulates substrate utilization for mitochondrial respiration.
Alina Luchkova, Ana Mata, Susana Cadenas
wiley   +1 more source