Results 71 to 80 of about 2,318 (179)
Redox Biology, 2013 Background: Fetal-to-neonatal transition is associated with oxidative stress. In preterm infants, immaturity of the antioxidant system favours supplemental oxygen-derived morbidity and mortality.
Javier Escobar +9 more
doaj +1 more source
BioMed Research International, Volume 2026, Issue 1, 2026.Reactive oxygen species (ROS) are highly reactive molecules generated through endogenous metabolic pathways and exogenous environmental exposures. While essential for physiological processes—including cell signaling, proliferation, differentiation, immune defense, and neurotransmission—dysregulated ROS production contributes to oxidative stress and ...
Alkhaddour Aziz +2 more
wiley +1 more source
MOLECULAR MECHANISM OF THE REDUCTION OF CYSTEINE SULFINIC ACID OF PEROXIREDOXIN TO CYSTEINE BY MAMMALIAN SULFIREDOXIN [PDF]
The FASEB Journal, 2006 Among many proteins with cysteine sulfinic acid (Cys–SO2H) residues, the sulfinic forms of certain peroxiredoxins (Prxs) are selectively reduced by sulfiredoxin (Srx) in the presence of ATP. All Srx enzymes contain a conserved cysteine residue. To elucidate the mechanism of the Srx‐catalyzed reaction, we generated various mutants of Srx and examined ...
Woojin, Jeong +4 more
openaire +2 more sources
Cellular Coordination of Transcription Factors and Regulatory Genes for Cryptococcal Virulence
Cellular Microbiology, Volume 2026, Issue 1, 2026.Cryptococcus neoformans is an opportunistic pathogen belonging to the family Cryptococcaceae, capable of causing systemic and invasive fungal infections in humans and animals. The infection caused by Cryptococcus is lethal primarily in immunocompromised individuals due to the overwhelming expression of virulence factors that drive cryptococcosis in ...
Olufemi S. Folorunso +2 more
wiley +1 more source
Hyperoxidation of Peroxiredoxin 6 Induces Alteration from Dimeric to Oligomeric State
Antioxidants, 2019 Peroxiredoxins(Prdx), the family of non-selenium glutathione peroxidases, are important antioxidant enzymes that defend our system from the toxic reactive oxygen species (ROS).
Sharifun Shahnaj +8 more
doaj +1 more source
Physiological Reports, Volume 13, Issue 18, September 2025.Abstract Triple‐negative breast cancer (TNBC) predominantly affects young and minority women, with cytotoxic chemotherapy regimens causing severe side effects, including chronic cardiac dysfunction. Obesity worsens TNBC survival. Inositol‐requiring enzyme‐1 (IRE1), a key arm of the unfolded protein response (UPR), influences tumor progression.
Yismeilin R. Feliz‐Mosquea +5 more
wiley +1 more source
Molecular Medicine Reports, 2020 Sulfiredoxin-1 (SRX1) is a conserved endogenous antioxidative protein, which is involved in the response to cellular damage caused by oxidative stress.
Zhi-Liang Wu +4 more
semanticscholar +1 more source
Oxidative Stress in Antigen Processing and Presentation
MedComm – Oncology, Volume 4, Issue 2, June 2025.Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang +9 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 69, Issue 8, April 2025.In this study, we show that the sulfur compound commonly found in cruciferous and allium vegetables and the main human metabolite of S‐methyl‐L‐cysteine sulfoxide, called S‐methyl methanethiosulfonate (MMTSO), alters energy metabolism in DU145 prostate cancer cells.
Gemma Beasy +8 more
wiley +1 more source
Frontiers in Plant Science, 2013 Mitochondrial respiration provides the energy needed to drive metabolic and transport processes in cells. Mitochondria are a significant site of reactive oxygen species (ROS) production in plant cells, and redox-system components obey fine regulation ...
Juan José Lázaro +7 more
doaj +1 more source