Results 71 to 80 of about 1,937 (151)

Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin – Thioredoxin system. 1. Understanding commonalities and differences among cell types

Redox Biology, 2018
The system (PTTRS) formed by typical 2-Cys peroxiredoxins (Prx), thioredoxin (Trx), Trx reductase (TrxR), and sulfiredoxin (Srx) is central in antioxidant protection and redox signaling in the cytoplasm of eukaryotic cells.
Gianluca Selvaggio, Pedro M.B.M. Coelho, Armindo Salvador   +2 more
doaj   +1 more source

The flavohemoglobin Yhb1 is a new interacting partner of the heme transporter Str3

Molecular Microbiology, Volume 122, Issue 1, Page 29-49, July 2024.
A new mechanism for Yhb1 (orange) heme‐dependent activation involves direct interaction with the cell‐surface heme transporter Str3 (blue) in the presence of exogenous heme (red). Upon exposure to nitric oxide (˙NO), the expression of yhb1+ is induced, as its promoter is liberated from Fep1 repression (violet).
Florie Lo Ying Ping, Tobias Vahsen, Ariane Brault, Raphaël Néré, Simon Labbé   +4 more
wiley   +1 more source

Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine

Redox Biology, 2014
Thioredoxin reductase (TR) catalyzes the reduction of thioredoxin (TRX), which in turn reduces mammalian typical 2-Cys peroxiredoxins (PRXs 1–4), thiol peroxidases implicated in redox homeostasis and cell signaling.
Brian Cunniff, Gregg W. Snider, Nicholas Fredette, Jason Stumpff, Robert J. Hondal, Nicholas H. Heintz   +5 more
doaj   +1 more source

Inhibiting the Keap1/Nrf2 Protein‐Protein Interaction with Protein‐Like Polymers

Advanced Materials, Volume 36, Issue 21, May 23, 2024.
The protein‐protein interaction between Kelch‐like ECH associating protein 1 (Keap1) and nuclear factor erthroid 2‐related factor 2 (Nrf2) regulates the antioxidant response. Protein‐like polymers (PLPs) were developed to inhibit the Keap1/Nrf2 PPI as multivalent, stable, and bioactive compounds.
Kendal P. Carrow, Haylee L. Hamilton, Madeline P. Hopps, Yang Li, Baofu Qiao, N. Connor Payne, Matthew P. Thompson, Xiaoyu Zhang, Assa Magassa, Mara Fattah, Shivangi Agarwal, Michael P. Vincent, Marina Buyanova, Paul A. Bertin, Ralph Mazitschek, Monica Olvera de la Cruz, Delinda A. Johnson, Jeffrey A. Johnson, Nathan C. Gianneschi   +18 more
wiley   +1 more source

Cysteine oxidation as a regulatory mechanism of Arabidopsis plastidial NAD‐dependent malate dehydrogenase

Physiologia Plantarum, Volume 176, Issue 3, May/June 2024.
Abstract Malate dehydrogenases (MDHs) catalyze a reversible NAD(P)‐dependent‐oxidoreductase reaction that plays an important role in central metabolism and redox homeostasis of plant cells. Recent studies suggest a moonlighting function of plastidial NAD‐dependent MDH (plNAD‐MDH; EC 1.1.1.37) in plastid biogenesis, independent of its enzyme activity ...
Maike Cosse, Tanja Rehders, Jürgen Eirich, Iris Finkemeier, Jennifer Selinski   +4 more
wiley   +1 more source

Cysteine post‐translational modifications regulate protein interactions of caveolin‐3

The FASEB Journal, Volume 38, Issue 5, 15 March 2024.
Caveolins are the structural proteins of caveolae. Caveolin‐1 is ubiquitously expressed, and caveolin‐3 is muscle‐specific. We report that a caveolin‐3 protomer is palmitoylated on 6 cysteines per monomer: twice as many sites as for caveolin‐1. Redox stress‐induced glutathiolation near the caveolin‐3 amino terminus abolishes its interaction with ...
Fiona Ashford, Chien‐Wen Kuo, Emma Dunning, Elaine Brown, Sarah Calagan, Izzy Jayasinghe, Colin Henderson, William Fuller, Krzysztof Wypijewski   +8 more
wiley   +1 more source

Unraveling Fungal Radiation Resistance Regulatory Networks through the Genome-Wide Transcriptome and Genetic Analyses of Cryptococcus neoformans

mBio, 2016
The basidiomycetous fungus Cryptococcus neoformans has been known to be highly radiation resistant and has been found in fatal radioactive environments such as the damaged nuclear reactor at Chernobyl. To elucidate the mechanisms underlying the radiation
Kwang-Woo Jung, Dong-Hoon Yang, Min-Kyu Kim, Ho Seong Seo, Sangyong Lim, Yong-Sun Bahn   +5 more
doaj   +1 more source

Biosynthesis of Zinc Oxide Nanoparticles Using Garlic Peel Extract and Their Antibacterial Potential

Microbiology Research
Zinc oxide nanoparticles (ZnO NPs) have gathered interest because of their unique characteristics and potential applications. In the current work, ZnO NPs underwent an eco-friendly biosynthesis process using garlic peel extract.
Ali Abdelmoteleb, Benjamín Valdez-Salas, Ernesto Beltran-Partida, Vianey Mendez-Trujillo, Daniel González-Mendoza, Olivia Tzintzun-Camacho, Ahmed F. Roumia   +6 more
doaj   +1 more source

Origins of Ultrasensitivity and Complex Signaling Dynamics of Cellular Hydrogen Peroxide and Peroxiredoxin

Antioxidants
Hydrogen peroxide (H2O2) plays a crucial role in cell signaling in response to physiological and environmental perturbations. H2O2 can oxidize typical 2-Cys peroxiredoxin (PRX) first into a sulfenic acid, which resolves into a disulfide that can be ...
Shengnan Liu, Jingbo Pi, Qiang Zhang
doaj   +1 more source

Enzymology of Sulfiredoxine, a sulfinyl reductase : characterization of the catalytic mechanism

, 2009
Les peroxyrédoxines à deux cystéines typiques (2-Cys Prx) sont impliquées dans la résistance des cellules au stress oxydant associé à H2O2, en réduisant H2O2 en H2O. En parallèle, ces enzymes participent à la transduction du signal dépendant de H2O2 en tant que second messager, via leur état rédox.
openaire   +2 more sources