Results 51 to 60 of about 2,318 (179)

Sulfiredoxin-1 Inhibits PDGF-BB-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Enhancing the Activation of Nrf2/ARE Signaling.

International Heart Journal, 2022
Sulfiredoxin1 (Srxn1), an endogenous antioxidant protein, is involved in cardiovascular diseases. In this study, we aimed to investigate the role of Srxn1 in VSMCs and its molecular mechanism.
Haijie Jiang, Yueyan Zhao, Panyang Feng, Yan Liu   +3 more
semanticscholar   +1 more source

Mitochondrial Peroxiredoxin-IIF (PRXIIF) Activity and Function during Seed Aging

Antioxidants, 2022
Mitochondria play a major role in energy metabolism, particularly in cell respiration, cellular metabolism, and signal transduction, and are also involved in other processes, such as cell signaling, cell cycle control, cell growth, differentiation and ...
Ewelina A. Klupczyńska, Karl-Josef Dietz, Arleta Małecka, Ewelina Ratajczak   +3 more
doaj   +1 more source

Effects of Srxn1 on growth and Notch signalling of astrocyte induced by hydrogen peroxide

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Objective To investigate the effect of Sulfiredoxin-1 (Srxn1) on astrocyte injury induced by hydrogen peroxide (H2O2).Methods Observing the changes of H2O2 on contents of lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD) and ...
Lan Li, Guangjun Lin, Huizi Gu, Lei Yu, Changwei Ni   +4 more
doaj   +1 more source

Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis [PDF]

Carcinogenesis, 2014
Sulfiredoxin (Srx), the exclusive enzyme that reduces the hyperoxidized inactive form of peroxiredoxins (Prxs), has been found highly expressed in several types of human skin cancer. To determine whether Srx contributed to skin tumorigenesis in vivo, Srx null mice were generated on an FVB background.
Lisha, Wu, Hong, Jiang, Hedy A, Chawsheen, Murli, Mishra, Matthew R, Young, Matthieu, Gerard, Michel B, Toledano, Nancy H, Colburn, Qiou, Wei   +8 more
openaire   +2 more sources

Srxn1 Overexpression Protect Against Cardiac Remodelling by Inhibiting Oxidative Stress and Inflammation. [PDF]

J Cell Mol Med
ABSTRACT Oxidative stress and inflammation are common medical issues contributing to the onset and progression of heart failure (HF). Sulfiredoxin 1 (Srxn1) is a key regulatory factor in the antioxidant response. This study aimed to examine the effect of Srxn1 in HF.
Wang H, Yang Y, Ye Y, Wei X, Chen S, Cheng B, Lv Y.   +6 more
europepmc   +2 more sources

Candida albicans resistance to hypochlorous acid

mBio, 2023
Innate immune cells, especially neutrophils, play key roles in protecting against infection by Candida albicans and other fungal pathogens. A distinct aspect of neutrophils compared to other phagocytes is that they make much higher levels of ...
Lois M. Douglas, Kyunghun Min, James B. Konopka   +2 more
doaj   +1 more source

Increased sulfiredoxin-1 levels as compensatory mechanism against reactive oxygen species in women with gestational diabetes mellitus

Journal of Turkish Society of Obstetric and Gynecology, 2021
Objective: This study aimed to investigate the correlation between serum Sulfiredoxin-1 (Srx-1) levels and gestational diabetes mellitus (GDM). Materials and Methods A total of 40 patients diagnosed with GDM according to the American Diabetes Association
B. Tatar, U. Turhan
semanticscholar   +1 more source

Nrf2-activated expression of sulfiredoxin contributes to urethane-induced lung tumorigenesis [PDF]

Cancer Letters, 2018
Lung cancer is the leading cause of cancer death worldwide. Cigarette smoking and exposure to chemical carcinogens are among the risk factors of lung tumorigenesis. In this study, we found that cigarette smoke condensate and urethane significantly stimulated the expression of sulfiredoxin (Srx) at the transcript and protein levels in cultured normal ...
Murli Mishra, Hong Jiang, Hedy A. Chawsheen, Matthieu Gerard, Michel B. Toledano, Qiou Wei   +5 more
openaire   +3 more sources

Evidence for the Formation of a Covalent Thiosulfinate Intermediate with Peroxiredoxin in the Catalytic Mechanism of Sulfiredoxin [PDF]

Journal of Biological Chemistry, 2008
The typical 2-Cys peroxiredoxins are thiol-peroxidases involved in the physiology of hydrogen peroxide not only as a toxic but also as a signaling molecule. Coordination of these functions depends on the sulfinylation of the catalytic Cys, a modification reversed by ATP-dependent sulfiredoxin, which specifically reduces the sulfinic acid group of ...
Roussel, Xavier, Béchade, Guillaume, Kriznik, Alexandre, van Dorsselaer, Alain, Sanglier-Cianferani, Sarah, Branlant, Guy, Rahuel-Clermont, Sophie   +6 more
openaire   +4 more sources

South African Herbal Teas and Diabetes‐Mediated Mitochondrial Dysfunction: Emerging Evidence and Mechanistic Insights

Journal of Food Science, Volume 91, Issue 8, August 2026.
ABSTRACT Type 2 diabetes mellitus (T2DM) is a central component of the metabolic syndrome (MetS) and is associated with underlying mitochondrial dysfunction. Disruption of mitochondrial homeostasis impairs cellular energy metabolism and contributes to the overproduction of reactive oxygen species (ROS), leading to oxidative stress, chronic inflammation,
Shanika Reddy, Naeem Sheik Abdul, Taskeen Fathima Docrat, Jeanine Marnewick   +3 more
wiley   +1 more source