Results 51 to 60 of about 1,937 (151)

Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins [PDF]

Journal of Biological Chemistry, 2005
Cysteine residues of certain peroxiredoxins (Prxs) undergo reversible oxidation to sulfinic acid (Cys-SO2H) and the reduction reaction is catalyzed by sulfiredoxin (Srx). Specific Cys residues of various other proteins are also oxidized to sulfinic acid, suggesting that formation of Cys-SO2H might be a novel posttranslational modification that ...
Hyun Ae, Woo, Woojin, Jeong, Tong-Shin, Chang, Kwang Joo, Park, Sung Jun, Park, Jeong Soo, Yang, Sue Goo, Rhee   +6 more
openaire   +2 more sources

Dietary influences on chemotherapy sensitivity and cardiotoxicity modulated by IRE1 targeting in triple‐negative breast cancer in female mice

Physiological Reports, Volume 13, Issue 18, September 2025.
Abstract Triple‐negative breast cancer (TNBC) predominantly affects young and minority women, with cytotoxic chemotherapy regimens causing severe side effects, including chronic cardiac dysfunction. Obesity worsens TNBC survival. Inositol‐requiring enzyme‐1 (IRE1), a key arm of the unfolded protein response (UPR), influences tumor progression.
Yismeilin R. Feliz‐Mosquea, Adam S. Wilson, Nildris Cruz‐Diaz, Valerie S. Payne, Katherine L. Cook, David R. Soto‐Pantoja   +5 more
wiley   +1 more source

Evidence for the Formation of a Covalent Thiosulfinate Intermediate with Peroxiredoxin in the Catalytic Mechanism of Sulfiredoxin [PDF]

Journal of Biological Chemistry, 2008
The typical 2-Cys peroxiredoxins are thiol-peroxidases involved in the physiology of hydrogen peroxide not only as a toxic but also as a signaling molecule. Coordination of these functions depends on the sulfinylation of the catalytic Cys, a modification reversed by ATP-dependent sulfiredoxin, which specifically reduces the sulfinic acid group of ...
Roussel, Xavier, Béchade, Guillaume, Kriznik, Alexandre, van Dorsselaer, Alain, Sanglier-Cianferani, Sarah, Branlant, Guy, Rahuel-Clermont, Sophie   +6 more
openaire   +3 more sources

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Balancing anti-inflammatory and anti-oxidant responses in murine bone marrow derived macrophages.

PLoS ONE, 2017
RationaleThe underlying pathophysiology of bronchopulmonary dysplasia includes a macrophage-mediated host response orchestrated by anti-inflammatory peroxisome proliferator-activated receptor gamma (PPARγ) and anti-oxidant nuclear factor (erythroid ...
Christopher R Nitkin, Tracey L Bonfield
doaj   +1 more source

S‐Methyl Methanethiosulfonate, the Main Human Metabolite of S‐Methyl‐L‐Cysteine Sulfoxide, Alters Energy Metabolism in Prostate Cancer Cells

Molecular Nutrition &Food Research, Volume 69, Issue 8, April 2025.
In this study, we show that the sulfur compound commonly found in cruciferous and allium vegetables and the main human metabolite of S‐methyl‐L‐cysteine sulfoxide, called S‐methyl methanethiosulfonate (MMTSO), alters energy metabolism in DU145 prostate cancer cells.
Gemma Beasy, Federico Bernuzzi, Priscilla Day‐Walsh, Perla Tronsco‐Rey, Marianne Defernez, Shikha Saha, Richard F. Mithen, Maria H. Traka, Paul A. Kroon   +8 more
wiley   +1 more source

MOLECULAR MECHANISM OF THE REDUCTION OF CYSTEINE SULFINIC ACID OF PEROXIREDOXIN TO CYSTEINE BY MAMMALIAN SULFIREDOXIN [PDF]

The FASEB Journal, 2006
Among many proteins with cysteine sulfinic acid (Cys–SO2H) residues, the sulfinic forms of certain peroxiredoxins (Prxs) are selectively reduced by sulfiredoxin (Srx) in the presence of ATP. All Srx enzymes contain a conserved cysteine residue. To elucidate the mechanism of the Srx‐catalyzed reaction, we generated various mutants of Srx and examined ...
Woojin, Jeong, Sung Jun, Park, Tong-Shin, Chang, Duck-Yeon, Lee, Sue Goo, Rhee   +4 more
openaire   +2 more sources

Prolonging in utero-like oxygenation after birth diminishes oxidative stress in the lung and brain of mice pups

Redox Biology, 2013
Background: Fetal-to-neonatal transition is associated with oxidative stress. In preterm infants, immaturity of the antioxidant system favours supplemental oxygen-derived morbidity and mortality.
Javier Escobar, Elena Cubells, Masahiro Enomoto, Guillermo Quintás, Julia Kuligowski, Cristina Martinez Fernández, Isabel Torres-Cuevas, Juan Sastre, Jaques Belik, Máximo Vento   +9 more
doaj   +1 more source

Proteomic analysis across aged tissues reveals distinct signatures and the crucial involvement of midgut barrier function in the regulation of aging

Aging Cell, Volume 24, Issue 1, January 2025.
Proteomic analysis reveals that instead of specific proteins, different tissues exhibit common dysregulated functional networks. Specifically, the integrity of the midgut barrier function is compromised during aging, which can be restored through the downregulation of the insulin receptor (InR).
Congying Zhang, Jinlong Wang, Tianzhao Yao, Jiaxin Hu, Feifei Sun, Chunlu Feng, Zhendong Sun, Yuzhuo Shao, Zhu Wang, Jiarui Wu, Yunpeng Huang   +10 more
wiley   +1 more source

Hyperoxidation of Peroxiredoxin 6 Induces Alteration from Dimeric to Oligomeric State

Antioxidants, 2019
Peroxiredoxins(Prdx), the family of non-selenium glutathione peroxidases, are important antioxidant enzymes that defend our system from the toxic reactive oxygen species (ROS).
Sharifun Shahnaj, Rimpy Kaur Chowhan, Potshangbam Angamba Meetei, Pushpa Kakchingtabam, Khundrakpam Herojit Singh, Laishram Rajendrakumar Singh, Potshangbam Nongdam, Aron B. Fisher, Hamidur Rahaman   +8 more
doaj   +1 more source