Results 1 to 10 of about 176,792 (217)

Influence of electrolyte imbalance on regional wall motion abnormalities in STEMI patients of North Indian origin

Frontiers in Cardiovascular Medicine, 2023
Assessing regional wall motion abnormalities (RWMA) in the myocardium may provide early diagnosis and treat chronic remodeling in STEMI patients. We assessed RWMA in 217 subjects with anterior STEMI admitted to Era University Hospital in Lucknow, UP ...
S. Mohd. Shiraz Rizvi, Sini Sunny, Irshad A. Wani, Farzana Mahdi, Zeeshan H. Zaidi, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran   +6 more
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Mitochondrial metabolism and redox signaling [PDF]

Redox Biology
Annika Müller-Eigner, Andrew P. Wojtovich   +1 more
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Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice

BMC Genomics, 2017
Background Nuclear Factor Erythroid-derived 2-like 2 (Nrf2) senses oxidative environments and/or stress and initiates a cytoprotective response through transcriptional activation of antioxidant and detoxification genes.
Justin M. Quiles, Madhusudhanan Narasimhan, Gobinath Shanmugam, Brett Milash, John R. Hoidal, Namakkal S. Rajasekaran   +5 more
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Redox Homeostasis in Pancreatic β-Cells: From Development to Failure

Antioxidants, 2021
Redox status is a key determinant in the fate of β-cell. These cells are not primarily detoxifying and thus do not possess extensive antioxidant defense machinery.
Štěpánka Benáková, Blanka Holendová, Lydie Plecitá-Hlavatá   +2 more
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Redox Signaling from Mitochondria: Signal Propagation and Its Targets

Biomolecules, 2020
Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling.
Petr Ježek, Blanka Holendová, Lydie Plecitá-Hlavatá   +2 more
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Redox signaling at the crossroads of human health and disease

MedComm, 2022
Redox biology is at the core of life sciences, accompanied by the close correlation of redox processes with biological activities. Redox homeostasis is a prerequisite for human health, in which the physiological levels of nonradical reactive oxygen ...
Jing Zuo, Zhe Zhang, Maochao Luo, Li Zhou, Edouard C. Nice, Wei Zhang, Chuang Wang, Canhua Huang   +7 more
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Identification of transcriptome signature for myocardial reductive stress

Redox Biology, 2017
The nuclear factor erythroid 2 like 2 (Nfe2l2/Nrf2) is a master regulator of antioxidant gene transcription. We recently identified that constitutive activation of Nrf2 (CaNrf2) caused reductive stress (RS) in the myocardium.
Justin M. Quiles, Madhusudhanan Narasimhan, Timothy Mosbruger, Gobinath Shanmugam, David Crossman, Namakkal S. Rajasekaran   +5 more
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Exercise Mediated Nrf2 Signaling Protects the Myocardium From Isoproterenol-Induced Pathological Remodeling

Frontiers in Cardiovascular Medicine, 2019
Although exercise derived activation of Nrf2 signaling augments myocardial antioxidant signaling, the molecular mechanisms underlying the benefits of moderate exercise training (MET) in the heart remain elusive.
Gobinath Shanmugam, Anil K. Challa, Asokan Devarajan, Baskaran Athmanathan, Silvio H. Litovsky, Prasanna Krishnamurthy, Christopher J. Davidson, Namakkal Soorappan Rajasekaran, Namakkal Soorappan Rajasekaran, Namakkal Soorappan Rajasekaran   +9 more
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A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes

Redox Biology, 2016
Antagonizing TNF-α signaling attenuates chronic inflammatory disease, but is associated with adverse effects on the cardiovascular system. Therefore the impact of TNF-α on basal control of redox signaling events needs to be understand in more depth. This
Gobinath Shanmugam, Madhusudhanan Narasimhan, Ramasamy Sakthivel, Rajesh Kumar R, Christopher Davidson, Sethu Palaniappan, William W. Claycomb, John R. Hoidal, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran   +9 more
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Dynamic Redox Regulation of IL-4 Signaling. [PDF]

PLoS Computational Biology, 2015
Quantifying the magnitude and dynamics of protein oxidation during cell signaling is technically challenging. Computational modeling provides tractable, quantitative methods to test hypotheses of redox mechanisms that may be simultaneously operative ...
Gaurav Dwivedi, Margaret A Gran, Pritha Bagchi, Melissa L Kemp   +3 more
doaj   +1 more source