Results 1 to 10 of about 191,431 (114)

Redox Signaling from Mitochondria: Signal Propagation and Its Targets

Biomolecules, 2020
Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling.
Petr Ježek, Petr Ježek, Blanka Holendová   +2 more
exaly   +3 more sources

Redox signaling at the crossroads of human health and disease

MedComm, 2022
Redox biology is at the core of life sciences, accompanied by the close correlation of redox processes with biological activities. Redox homeostasis is a prerequisite for human health, in which the physiological levels of nonradical reactive oxygen ...
Edouard C Nice, Chuang Wang, Li Zhou
exaly   +2 more sources

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

Redox Biology, 2017
Hydrogen peroxide emerged as major redox metabolite operative in redox sensing, signaling and redox regulation. Generation, transport and capture of H2O2 in biological settings as well as their biological consequences can now be addressed.
Helmut Sies
exaly   +3 more sources

Localized redox relays as a privileged mode of cytoplasmic hydrogen peroxide signaling

Redox Biology, 2017
Hydrogen peroxide (H2O2) is a key signaling agent. Its best characterized signaling actions in mammalian cells involve the early oxidation of thiols in cytoplasmic phosphatases, kinases and transcription factors.
Rui Travasso, Anahita Bayani, Armindo Salvador   +2 more
exaly   +3 more sources

Endothelial Drp1 integrates VEGF-induced redox signaling with glycolysis through cysteine oxidation to drive angiogenesis [PDF]

Nature Communications
Angiogenesis is essential for development and tissue repair after ischemia. Reactive oxygen species (ROS) act as signaling molecules that promote angiogenesis in endothelial cells (ECs) which mainly rely on aerobic glycolysis for energy production ...
Sheela Nagarkoti, Young-Mee Kim, Archita Das, Dipankar Ash, Eric A. Vitriol, Tracy-Ann Read, Varadarajan Sudhahar, Md. Selim Hossain, Shikha Yadav, Stephanie Kelley Spears, Kelvin N. Orji, Maritza J. Romero, Rudolf Lucas, David Stepp, Eric J. Belin de Chantemele, Ruth B. Caldwell, David JR. Fulton, Tohru Fukai, Masuko Ushio-Fukai   +18 more
doaj   +2 more sources

Influence of electrolyte imbalance on regional wall motion abnormalities in STEMI patients of North Indian origin

Frontiers in Cardiovascular Medicine, 2023
Assessing regional wall motion abnormalities (RWMA) in the myocardium may provide early diagnosis and treat chronic remodeling in STEMI patients. We assessed RWMA in 217 subjects with anterior STEMI admitted to Era University Hospital in Lucknow, UP ...
S. Mohd. Shiraz Rizvi, Sini Sunny, Irshad A. Wani, Farzana Mahdi, Zeeshan H. Zaidi, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran   +6 more
doaj   +1 more source

Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice

BMC Genomics, 2017
Background Nuclear Factor Erythroid-derived 2-like 2 (Nrf2) senses oxidative environments and/or stress and initiates a cytoprotective response through transcriptional activation of antioxidant and detoxification genes.
Justin M. Quiles, Madhusudhanan Narasimhan, Gobinath Shanmugam, Brett Milash, John R. Hoidal, Namakkal S. Rajasekaran   +5 more
doaj   +1 more source

Redox Homeostasis in Pancreatic β-Cells: From Development to Failure

Antioxidants, 2021
Redox status is a key determinant in the fate of β-cell. These cells are not primarily detoxifying and thus do not possess extensive antioxidant defense machinery.
Štěpánka Benáková, Blanka Holendová, Lydie Plecitá-Hlavatá   +2 more
doaj   +1 more source

Identification of transcriptome signature for myocardial reductive stress

Redox Biology, 2017
The nuclear factor erythroid 2 like 2 (Nfe2l2/Nrf2) is a master regulator of antioxidant gene transcription. We recently identified that constitutive activation of Nrf2 (CaNrf2) caused reductive stress (RS) in the myocardium.
Justin M. Quiles, Madhusudhanan Narasimhan, Timothy Mosbruger, Gobinath Shanmugam, David Crossman, Namakkal S. Rajasekaran   +5 more
doaj   +1 more source

Exercise Mediated Nrf2 Signaling Protects the Myocardium From Isoproterenol-Induced Pathological Remodeling

Frontiers in Cardiovascular Medicine, 2019
Although exercise derived activation of Nrf2 signaling augments myocardial antioxidant signaling, the molecular mechanisms underlying the benefits of moderate exercise training (MET) in the heart remain elusive.
Gobinath Shanmugam, Anil K. Challa, Asokan Devarajan, Baskaran Athmanathan, Silvio H. Litovsky, Prasanna Krishnamurthy, Christopher J. Davidson, Namakkal Soorappan Rajasekaran, Namakkal Soorappan Rajasekaran, Namakkal Soorappan Rajasekaran   +9 more
doaj   +1 more source