Distinct Roles of Nrf1 and Nrf2 in Monitoring the Reductive Stress Response to Dithiothreitol (DTT) [PDF]
Antioxidants, 2022 Transcription factor Nrf2 (nuclear factor, erythroid 2-like 2, encoded by Nfe2l2) has been accepted as a key player in redox regulatory responses to oxidative or reductive stresses.
Reziyamu Wufuer +6 more
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Redox Imbalance in Inflammation: The Interplay of Oxidative and Reductive Stress [PDF]
AntioxidantsRedox imbalance plays a pivotal role in the regulation of inflammation, influencing both the onset and progression of various inflammatory conditions. While the pro-inflammatory role of oxidative stress (OS) is well established, the impact of reductive ...
Francesco Bellanti +5 more
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New Insights into Oxidative and Reductive Stress Responses and Their Relation to the Anticancer Activity of Selenium-Containing Compounds as Hydrogen Selenide Donors [PDF]
Biology, 2023 Redox balance is important for the homeostasis of normal cells, but also for the proliferation, progression, and survival of cancer cells. Both oxidative and reductive stress can be harmful to cells.
Agnieszka Krakowiak, Sylwia Pietrasik
doaj +2 more sources
Reductive Stress and Ferroptosis: Linking Insulin Signaling to Metabolic Dysfunction [PDF]
BiomoleculesReductive stress, characterized by excessive reducing equivalents such as NADH, NADPH, and reduced glutathione (GSH), is increasingly recognized as a pathophysiological counterpart to oxidative stress.
Udayakumar Karunakaran, Suma Elumalai
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Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy [PDF]
Advanced ScienceRedox balance is crucial for cellular function and adaptation to environmental changes, with its disruption playing a key role in the progression of various diseases, including cancer.
Yumin Mao +8 more
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Role of Reductive versus Oxidative Stress in Tumor Progression and Anticancer Drug Resistance
Cells, 2021 Redox homeostasis is not only essential for the maintenance of normal physiological functions, but also plays an important role in the growth, survival, and therapy resistance of cancer cells.
Kyung-Soo Chun +2 more
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NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis [PDF]
Advanced ScienceCopper (Cu) is an essential trace element for cellular metabolism, while excessive Cu accumulation leads to neurotoxicity. Current therapeutic strategies for Cu overload remain inadequate in mitigating neurological symptoms.
Si‐Yi Zhang +3 more
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Reductive stress induces unresolved ER stress and proteotoxic cardiomyopathy [PDF]
Redox BiologyChronic reductive stress (cRS), induced by constitutive activation of Nrf2 in transgenic (TG) mouse hearts leads to pathological cardiac remodeling and diastolic dysfunction.
Sini Sunny +13 more
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NADH Reductive Stress and Its Correlation with Disease Severity in Leigh Syndrome: A Pilot Study Using Patient Fibroblasts and a Mouse Model [PDF]
BiomoleculesNicotinamide adenine dinucleotide (NAD) is a critical cofactor in mitochondrial energy production. The NADH/NAD+ ratio, reflecting the balance between NADH (reduced) and NAD+ (oxidized), is a key marker for the severity of mitochondrial diseases.
Tamaki Ishima +12 more
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Metabolic Responses to Reductive Stress
Antioxidants and Redox Signaling, 2020 Significance: Reducing equivalents (NAD(P)H and glutathione [GSH]) are essential for maintaining cellular redox homeostasis and for modulating cellular metabolism. Reductive stress induced by excessive levels of reduced NAD + (NADH), reduced NADP
Wusheng Xiao, Joseph Loscalzo
exaly +3 more sources