New Insights into Oxidative and Reductive Stress Responses and Their Relation to the Anticancer Activity of Selenium-Containing Compounds as Hydrogen Selenide Donors [PDF]
Biology, 2023 Redox balance is important for the homeostasis of normal cells, but also for the proliferation, progression, and survival of cancer cells. Both oxidative and reductive stress can be harmful to cells.
Agnieszka Krakowiak, Sylwia Pietrasik
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Reductive stress—a common metabolic feature of obesity and cancer [PDF]
Acta Pharmaceutica Sinica BReductive stress, characterized by rising level of NADH (nicotinamide adenine dinucleotide) for a status of NADH/NAD+ ratio elevation, has been reported in obesity and cancer.
Man Luo, Xiwen Ma, Jianping Ye
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Reductive stress promotes protein aggregation and impairs neurogenesis [PDF]
Redox Biology, 2020 Redox homeostasis regulates key cellular signaling in both physiology and pathology. While perturbations result in shifting the redox homeostasis towards oxidative stress are well documented, the influence of reductive stress (RS) in neurodegenerative ...
Kishore Kumar S Narasimhan +7 more
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Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy [PDF]
Advanced ScienceRedox balance is crucial for cellular function and adaptation to environmental changes, with its disruption playing a key role in the progression of various diseases, including cancer.
Yumin Mao +8 more
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Distinct Roles of Nrf1 and Nrf2 in Monitoring the Reductive Stress Response to Dithiothreitol (DTT) [PDF]
Antioxidants, 2022 Transcription factor Nrf2 (nuclear factor, erythroid 2-like 2, encoded by Nfe2l2) has been accepted as a key player in redox regulatory responses to oxidative or reductive stresses.
Reziyamu Wufuer +6 more
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Role of Reductive versus Oxidative Stress in Tumor Progression and Anticancer Drug Resistance
Cells, 2021 Redox homeostasis is not only essential for the maintenance of normal physiological functions, but also plays an important role in the growth, survival, and therapy resistance of cancer cells.
Kyung-Soo Chun +2 more
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Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging [PDF]
Antioxidants, 2023 This review is focused on the mechanisms that regulate health, disease and aging redox status, the signal pathways that counteract oxidative and reductive stress, the role of food components and additives with antioxidant properties (curcumin ...
Mitko Mladenov +10 more
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Reductive stress induces unresolved ER stress and proteotoxic cardiomyopathy [PDF]
Redox BiologyChronic reductive stress (cRS), induced by constitutive activation of Nrf2 in transgenic (TG) mouse hearts leads to pathological cardiac remodeling and diastolic dysfunction.
Sini Sunny +13 more
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Impaired Renal Function Due to Reductive Stress Is Associated with Excessive Consumption of Hibiscus sabdariffa Linnaeus [PDF]
AntioxidantsReductive stress (RS) results from the overactivity of the enzymatic and non-enzymatic antioxidant systems and from excess antioxidant agents that neutralize reactive oxygen species.
Linaloe Manzano-Pech +11 more
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Structural basis and regulation of the reductive stress response [PDF]
Cell, 2021 Although oxidative phosphorylation is best known for producing ATP, it also yields reactive oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological levels, a phenomenon known as reductive stress, impedes cellular ...
Andrew G Manford +2 more
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