Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging [PDF]
Antioxidants, 2023 This review is focused on the mechanisms that regulate health, disease and aging redox status, the signal pathways that counteract oxidative and reductive stress, the role of food components and additives with antioxidant properties (curcumin ...
Mitko Mladenov +10 more
doaj +3 more sources
Structural basis and regulation of the reductive stress response [PDF]
Cell, 2021 Although oxidative phosphorylation is best known for producing ATP, it also yields reactive oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological levels, a phenomenon known as reductive stress, impedes cellular ...
Karen Shih +2 more
exaly +4 more sources
Induction of Intracellular Reductive Stress with a Photoactivatable Phosphine Probe
CHIMIA, 2018 Reductive stress is a condition present in cells that have an increased concentration of reducing species, and it has been associated with a number of pathologies, such as neurodegenerative diseases and cancer.
Alina Tirla, Pablo Rivera-Fuentes
doaj +2 more sources
Cell Reports, 2016 Reductive stress leads to the loss of disulfide bond formation and induces the unfolded protein response of the endoplasmic reticulum (UPRER), necessary to regain proteostasis in the compartment.
Shuvadeep Maity +10 more
doaj +2 more sources
VHL-deficiency leads to reductive stress in renal cells. [PDF]
Free Radic Biol Med, 2023 Heritable renal cancer syndromes (RCS) are associated with numerous chromosomal alterations including inactivating mutations in von Hippel-Lindau (VHL) gene. Here we identify a novel aspect of the phenotype in VHL-deficient human renal cells.
Vellama H +14 more
europepmc +10 more sources
Impaired Renal Function Due to Reductive Stress Is Associated with Excessive Consumption of Hibiscus sabdariffa Linnaeus [PDF]
AntioxidantsReductive stress (RS) results from the overactivity of the enzymatic and non-enzymatic antioxidant systems and from excess antioxidant agents that neutralize reactive oxygen species.
Linaloe Manzano-Pech +11 more
doaj +2 more sources
Tandem Mass Tagging Based Identification of Proteome Signatures for Reductive Stress Cardiomyopathy [PDF]
Frontiers in Cardiovascular Medicine, 2022 Nuclear factor erythroid 2-related factor 2 (NRF2), a redox sensor, is vital for cellular redox homeostasis. We reported that transgenic mice expressing constitutively active Nrf2 (CaNrf2-TG) exhibit reductive stress (RS).
Sini Sunny +10 more
doaj +2 more sources
Reductive stress in mitochondria isolated from the carotid body of type 1 diabetic male Wistar rats [PDF]
Physiological ReportsThe carotid body (CB) senses changes in arterial O2 partial pressure (pO2) and glucose levels; therefore, it is key for the detection of hypoxia and hypoglycemia. The CB has been suggested to detect pO2 through an increase in reactive oxygen species (ROS)
Hector R. Tejeda‐Chavez +5 more
doaj +2 more sources
Media component bovine serum albumin facilitates the formation of mycobacterial biofilms in response to reductive stress [PDF]
BMC Microbiology, 2023 Background Mycobacterium tuberculosis (Mtb) forms physiologically relevant biofilms harboring drug-tolerant bacteria. This observation has brought the study of mycobacterial biofilms to the forefront of tuberculosis research.
Parminder Singh Mavi +2 more
doaj +2 more sources
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer [PDF]
Cell Metabolism, 2023 Weiss-Sadan T +26 more
exaly +3 more sources