Results 41 to 50 of about 28,838 (266)

Stress, Stress Reduction and Obesity in Childhood and Adolescence [PDF]

Hormone Research in Paediatrics, 2021
Background: Obesity in childhood and adolescence remains a great global health challenge. Stress exposure during childhood and adolescence is associated with a higher risk for obesity, yet the linkage between stress and obesity is multidimensional, and its biological and behavioral mechanisms are still not fully understood.
Claudia Kappes, Robert Stein, Antje Körner, Andreas Merkenschlager, Wieland Kiess   +4 more
openaire   +3 more sources

Antioxidant Paradox in Male Infertility: ‘A Blind Eye’ on Inflammation

Antioxidants, 2022
The pathophysiology of male infertility involves various interlinked endogenous pathways. About 50% of the cases of infertility in men are idiopathic, and oxidative stress (OS) reportedly serves as a central mechanism in impairing male fertility ...
Sulagna Dutta, Pallav Sengupta, Shubhadeep Roychoudhury, Srikumar Chakravarthi, Chee Woon Wang, Petr Slama   +5 more
doaj   +1 more source

Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress

Nature Communications, 2022
Reductive stress, reflected by the elevated intracellular NADH/NAD+ ratio, is associated with multiple human diseases. Here, the authors develop a genetic tool to manipulate the ratios of cellular NADH/NAD+ and NADPH/NADP+, and identify purine ...
Ronghui Yang, Chuanzhen Yang, Lingdi Ma, Yiliang Zhao, Zihao Guo, Jing Niu, Qiaoyun Chu, Yingmin Ma, Binghui Li   +8 more
doaj   +1 more source

ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits [PDF]

Cell Metabolism
Andrew L Markhard, Olga Goldberger
exaly   +2 more sources

Reductive stress impairs myogenic differentiation

Redox Biology, 2020
Myo-satellite cells regenerate and differentiate into skeletal muscle (SM) after acute or chronic injury. Changes in the redox milieu towards the oxidative arm at the wound site are known to compromise SM regeneration.
Namakkal S. Rajasekaran, Sandeep Balu Shelar, Dean P. Jones, John R. Hoidal   +3 more
doaj   +1 more source

The Alternative TrkAIII Splice Variant, a Targetable Oncogenic Participant in Human Cutaneous Malignant Melanoma

Cells, 2023
Post-therapeutic relapse, poor survival rates and increasing incidence justify the search for novel therapeutic targets and strategies in cutaneous malignant melanoma (CMM).
Lucia Cappabianca, Veronica Zelli, Cristina Pellegrini, Michela Sebastiano, Rita Maccarone, Marco Clementi, Alessandro Chiominto, Pierdomenico Ruggeri, Ludovica Cardelli, Marianna Ruggieri, Maddalena Sbaffone, Maria-Concetta Fargnoli, Stefano Guadagni, Antonietta R. Farina, Andrew R. Mackay   +14 more
doaj   +1 more source

Reductive Stress [PDF]

Hypertension, 2010
Normal cellular functions essentially depend on a balanced redox environment. Free radicals and nonradical oxidants can shift the redox balance toward a more “oxidized” state, which is counteracted by the intracellular antioxidant defense systems.
Johann Bauersachs, Julian D. Widder
openaire   +1 more source

The Dark Side of Nrf2 in the Heart

Frontiers in Physiology, 2020
Nuclear factor-erythroid factor 2-related factor 2 (Nrf2) is a critical transcription factor that regulates the expression of over 1000 genes in the cell under normal and stressed conditions.
Huimei Zang, Roy Oomen Mathew, Taixing Cui   +2 more
doaj   +1 more source

Redox Balance in Type 2 Diabetes: Therapeutic Potential and the Challenge of Antioxidant-Based Therapy

Antioxidants, 2023
Oxidative stress is an important factor in the development of type 2 diabetes (T2D) and associated complications. Unfortunately, most clinical studies have failed to provide sufficient evidence regarding the benefits of antioxidants (AOXs) in treating ...
Lital Argaev-Frenkel, Tovit Rosenzweig
doaj   +1 more source

Beyond Antioxidant Activity: Redox Properties of Catechins May Affect Changes in the DNA Methylation Profile—The Example of SRXN1 Gene

Antioxidants, 2023
The role of catechins in the epigenetic regulation of gene expression has been widely studied; however, if and how this phenomenon relates to the redox properties of these polyphenols remains unknown.
Patrycja Jakubek, Jovana Rajić, Monika Kuczyńska, Klaudia Suliborska, Mateusz Heldt, Karol Dziedziul, Melita Vidaković, Jacek Namieśnik, Agnieszka Bartoszek   +8 more
doaj   +1 more source