Results 21 to 30 of about 28,838 (266)

Induction of Intracellular Reductive Stress with a Photoactivatable Phosphine Probe

CHIMIA, 2018
Reductive stress is a condition present in cells that have an increased concentration of reducing species, and it has been associated with a number of pathologies, such as neurodegenerative diseases and cancer.
Alina Tirla, Pablo Rivera-Fuentes
doaj   +2 more sources

Reductive Stress and Ferroptosis: Linking Insulin Signaling to Metabolic Dysfunction [PDF]

Biomolecules
Reductive stress, characterized by excessive reducing equivalents such as NADH, NADPH, and reduced glutathione (GSH), is increasingly recognized as a pathophysiological counterpart to oxidative stress.
Udayakumar Karunakaran, Suma Elumalai
doaj   +2 more sources

Oxidative Homeostasis Regulates the Response to Reductive Endoplasmic Reticulum Stress through Translation Control

Cell Reports, 2016
Reductive stress leads to the loss of disulfide bond formation and induces the unfolded protein response of the endoplasmic reticulum (UPRER), necessary to regain proteostasis in the compartment.
Shuvadeep Maity, Asher Rajkumar, Latika Matai, Ajay Bhat, Asmita Ghosh, Ganesh Agam, Simarjot Kaur, Niraj R. Bhatt, Arnab Mukhopadhyay, Shantanu Sengupta, Kausik Chakraborty   +10 more
doaj   +2 more sources

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis [PDF]

Advanced Science
Copper (Cu) is an essential trace element for cellular metabolism, while excessive Cu accumulation leads to neurotoxicity. Current therapeutic strategies for Cu overload remain inadequate in mitigating neurological symptoms.
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
doaj   +2 more sources

NADH Reductive Stress and Its Correlation with Disease Severity in Leigh Syndrome: A Pilot Study Using Patient Fibroblasts and a Mouse Model [PDF]

Biomolecules
Nicotinamide adenine dinucleotide (NAD) is a critical cofactor in mitochondrial energy production. The NADH/NAD+ ratio, reflecting the balance between NADH (reduced) and NAD+ (oxidized), is a key marker for the severity of mitochondrial diseases.
Tamaki Ishima, Natsuka Kimura, Mizuki Kobayashi, Chika Watanabe, Eriko F. Jimbo, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Kei Murayama, Akira Ohtake, Ryozo Nagai, Hitoshi Osaka, Kenichi Aizawa   +12 more
doaj   +2 more sources

Metabolic Responses to Reductive Stress

Antioxidants and Redox Signaling, 2020
Significance: Reducing equivalents (NAD(P)H and glutathione [GSH]) are essential for maintaining cellular redox homeostasis and for modulating cellular metabolism. Reductive stress induced by excessive levels of reduced NAD + (NADH), reduced NADP
Wusheng Xiao, Joseph Loscalzo
exaly   +3 more sources

Redox Imbalance in Inflammation: The Interplay of Oxidative and Reductive Stress [PDF]

Antioxidants
Redox imbalance plays a pivotal role in the regulation of inflammation, influencing both the onset and progression of various inflammatory conditions. While the pro-inflammatory role of oxidative stress (OS) is well established, the impact of reductive ...
Francesco Bellanti, Anna Rita Daniela Coda, Maria Incoronata Trecca, Aurelio Lo Buglio, Gaetano Serviddio, Gianluigi Vendemiale   +5 more
doaj   +2 more sources

Tandem Mass Tagging Based Identification of Proteome Signatures for Reductive Stress Cardiomyopathy [PDF]

Frontiers in Cardiovascular Medicine, 2022
Nuclear factor erythroid 2-related factor 2 (NRF2), a redox sensor, is vital for cellular redox homeostasis. We reported that transgenic mice expressing constitutively active Nrf2 (CaNrf2-TG) exhibit reductive stress (RS).
Sini Sunny, Arun Jyothidasan, Cynthia L. David, Krishna Parsawar, Arul Veerappan, Arul Veerappan, Dean P. Jones, Steven Pogwizd, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran   +10 more
doaj   +2 more sources

Media component bovine serum albumin facilitates the formation of mycobacterial biofilms in response to reductive stress [PDF]

BMC Microbiology, 2023
Background Mycobacterium tuberculosis (Mtb) forms physiologically relevant biofilms harboring drug-tolerant bacteria. This observation has brought the study of mycobacterial biofilms to the forefront of tuberculosis research.
Parminder Singh Mavi, Shweta Singh, Ashwani Kumar   +2 more
doaj   +2 more sources

Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress [PDF]

Journal of Diabetes Research, 2014
Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin resistance and insulin secretion impairment. These disorders, if not intervened, will eventually be followed by appearance of frank diabetes.
Liang-Jun Yan
doaj   +2 more sources