Results 21 to 30 of about 2,924,310 (221)

The NLRP1 and CARD8 inflammasomes detect reductive stress [PDF]

Cell Reports, 2023
Daniel A Bachovchin, Jeffrey Hsiao, Daniel P Ball   +2 more
exaly   +2 more sources

Antioxidant Paradox in Male Infertility: ‘A Blind Eye’ on Inflammation

Antioxidants, 2022
The pathophysiology of male infertility involves various interlinked endogenous pathways. About 50% of the cases of infertility in men are idiopathic, and oxidative stress (OS) reportedly serves as a central mechanism in impairing male fertility ...
Sulagna Dutta, Pallav Sengupta, Shubhadeep Roychoudhury, Srikumar Chakravarthi, Chee Woon Wang, Petr Slama   +5 more
doaj   +1 more source

Endoplasmic reticulum oxidoreductin provides resilience against reductive stress and hypoxic conditions by mediating luminal redox dynamics. [PDF]

Plant Cell, 2022
Ugalde JM, Aller I, Kudrjasova L, et al. Endoplasmic reticulum oxidoreductin provides resilience against reductive stress and hypoxic conditions by mediating luminal redox dynamics. The Plant cell.
Ugalde JM, Aller I, Kudrjasova L, Schmidt RR, Schlößer M, Homagk M, Fuchs P, Lichtenauer S, Schwarzländer M, Müller-Schüssele SJ, Meyer AJ.   +10 more
europepmc   +2 more sources

Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress

Nature Communications, 2022
Reductive stress, reflected by the elevated intracellular NADH/NAD+ ratio, is associated with multiple human diseases. Here, the authors develop a genetic tool to manipulate the ratios of cellular NADH/NAD+ and NADPH/NADP+, and identify purine ...
Ronghui Yang, Chuanzhen Yang, Lingdi Ma, Yiliang Zhao, Zihao Guo, Jing Niu, Qiaoyun Chu, Yingmin Ma, Binghui Li   +8 more
doaj   +1 more source

ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits [PDF]

Cell Metabolism
Amy Deik, Andrew L Markhard, Stephanie Osganian   +2 more
exaly   +2 more sources

Reductive Stress-Induced Mitochondrial Dysfunction and Cardiomyopathy [PDF]

, 2020
The goal of this review was to summarize reported studies focusing on cellular reductive stress-induced mitochondrial dysfunction, cardiomyopathy, dithiothreitol- (DTT-) induced reductive stress, and reductive stress-related free radical reactions ...
Li, Chun-Yan, Yan, Liang-Jun, Ma, Wei-Xing, Tao, Ran, Wang, Xin-Ping   +4 more
core   +1 more source

Reductive stress impairs myogenic differentiation

Redox Biology, 2020
Myo-satellite cells regenerate and differentiate into skeletal muscle (SM) after acute or chronic injury. Changes in the redox milieu towards the oxidative arm at the wound site are known to compromise SM regeneration.
Namakkal S. Rajasekaran, Sandeep Balu Shelar, Dean P. Jones, John R. Hoidal   +3 more
doaj   +1 more source

Reductive stress promotes protein aggregation and impairs neurogenesis [PDF]

Redox Biology, 2020
Federica del Monte, Qin Wang, Thomas van Groen   +2 more
exaly   +2 more sources

The Alternative TrkAIII Splice Variant, a Targetable Oncogenic Participant in Human Cutaneous Malignant Melanoma

Cells, 2023
Post-therapeutic relapse, poor survival rates and increasing incidence justify the search for novel therapeutic targets and strategies in cutaneous malignant melanoma (CMM).
Lucia Cappabianca, Veronica Zelli, Cristina Pellegrini, Michela Sebastiano, Rita Maccarone, Marco Clementi, Alessandro Chiominto, Pierdomenico Ruggeri, Ludovica Cardelli, Marianna Ruggieri, Maddalena Sbaffone, Maria-Concetta Fargnoli, Stefano Guadagni, Antonietta R. Farina, Andrew R. Mackay   +14 more
doaj   +1 more source

The Dark Side of Nrf2 in the Heart

Frontiers in Physiology, 2020
Nuclear factor-erythroid factor 2-related factor 2 (Nrf2) is a critical transcription factor that regulates the expression of over 1000 genes in the cell under normal and stressed conditions.
Huimei Zang, Roy Oomen Mathew, Taixing Cui   +2 more
doaj   +1 more source