Results 41 to 50 of about 187,466 (308)

Redox Control of 20S Proteasome Gating

, 2012
The proteasome is the primary contributor in intracellular proteolysis. Oxidized or unstructured proteins can be degraded via a ubiquitin-and ATP-independent process by the free 20S proteasome (20SPT).
Netto, Luis E. S., Gozzo, Fabio C., Sogayar, Mari C., Santos, Luiz F. A., Demasi, Marcos A. A., Oliveira, Cristiano Luis Pinto de, Silva, Gustavo M., Klitzke, Clecio F., Simoes, Vanessa, Bicev, Renata Naporano, Demasi, Marilene   +10 more
core   +3 more sources

Use of Computational Biochemistry for Elucidating Molecular Mechanisms of Nitric Oxide Synthase

Computational and Structural Biotechnology Journal, 2019
Nitric oxide (NO) is an essential signaling molecule in the regulation of multiple cellular processes. It is endogenously synthesized by NO synthase (NOS) as the product of L-arginine oxidation to L-citrulline, requiring NADPH, molecular oxygen, and a ...
Emmanuelle Bignon, Salvatore Rizza, Giuseppe Filomeni, Elena Papaleo   +3 more
doaj   +1 more source

Protein tyrosine phosphorylation and protein tyrosine nitration in redox signaling

, 2008
Reversible phosphorylation of protein tyrosine residues by polypeptide growth factor-receptor protein tyrosine kinases is implicated in the control of fundamental cellular processes including the cell cycle, cell adhesion, and cell survival, as well as ...
Travassos, Luiz R. [UNIFESP], Roberto J. Arai, Luiz R. Travassos, Arai, Roberto J. [UNIFESP], Monteiro, Hugo P. [UNIFESP], Hugo P. Monteiro   +5 more
core   +1 more source

Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling

Frontiers in Physiology, 2017
Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling maintains the redox homeostasis and its activation is shown to suppress cardiac maladaptation.
Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran   +11 more
doaj   +1 more source

Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

Biomolecules, 2021
Mitochondria are essential organelles in physiology and kidney diseases, because they produce cellular energy required to perform their function. During mitochondrial metabolism, reactive oxygen species (ROS) are produced.
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, José Pedraza-Chaverri   +3 more
doaj   +1 more source

Redox signals in wound healing [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2008
Physical trauma represents one of the most primitive challenges that threatened survival. Healing a problem wound requires a multi-faceted comprehensive approach. First and foremost, the wound environment will have to be made receptive to therapies. Second, the appropriate therapeutic regimen needs to be identified and provided while managing systemic ...
Chandan K, Sen, Sashwati, Roy
openaire   +2 more sources

Quantitative biology of hydrogen peroxide signaling

Redox Biology, 2017
Hydrogen peroxide (H2O2) controls signaling pathways in cells by oxidative modulation of the activity of redox sensitive proteins denominated redox switches.
Fernando Antunes, Paula Matos Brito
doaj   +1 more source

Compartmentalized muscle redox signals controlling exercise metabolism – Current state, future challenges

Redox Biology, 2020
Exercise imposes cellular stress on contracting skeletal muscle fibers, forcing them to complete molecular adaptations to maintain homeostasis. There is mounting evidence that redox signaling by reactive oxygen species (ROS) is vital for skeletal muscle ...
Carlos Henriquez-Olguin, Roberto Meneses-Valdes, Thomas E. Jensen   +2 more
doaj   +1 more source

Reductive stress induces unresolved ER stress and proteotoxic cardiomyopathy

Redox Biology
Chronic reductive stress (cRS), induced by constitutive activation of Nrf2 in transgenic (TG) mouse hearts leads to pathological cardiac remodeling and diastolic dysfunction.
Sini Sunny, Rajesh Kumar Radhakrishnan, Asokan Devarajan, Juan Xavier Masjoan Juncos, Mohit Bansal, Xiaosen Ouyang, Jianhua Zhang, Min Xie, Silvio H. Litovsky, Joel D. Trinity, Matthew Might, Steven M. Pogwizd, Maria I. Kontaridis, Namakkal S. Rajasekaran   +13 more
doaj   +1 more source

Redox homeostasis: The Golden Mean of healthy living

Redox Biology, 2016
The notion that electrophiles serve as messengers in cell signaling is now widely accepted. Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as components of maintenance of a normal physiological steady state.
Fulvio Ursini, Matilde Maiorino, Henry Jay Forman   +2 more
doaj   +1 more source