Results 41 to 50 of about 1,330,295 (302)

Quantitative biology of hydrogen peroxide signaling

Redox Biology, 2017
Hydrogen peroxide (H2O2) controls signaling pathways in cells by oxidative modulation of the activity of redox sensitive proteins denominated redox switches.
Fernando Antunes, Paula Matos Brito
doaj   +1 more source

Compartmentalized muscle redox signals controlling exercise metabolism – Current state, future challenges

Redox Biology, 2020
Exercise imposes cellular stress on contracting skeletal muscle fibers, forcing them to complete molecular adaptations to maintain homeostasis. There is mounting evidence that redox signaling by reactive oxygen species (ROS) is vital for skeletal muscle ...
Carlos Henriquez-Olguin, Roberto Meneses-Valdes, Thomas E. Jensen   +2 more
doaj   +1 more source

Redox homeostasis: The Golden Mean of healthy living

Redox Biology, 2016
The notion that electrophiles serve as messengers in cell signaling is now widely accepted. Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as components of maintenance of a normal physiological steady state.
Fulvio Ursini, Matilde Maiorino, Henry Jay Forman   +2 more
doaj   +1 more source

Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

Biomolecules, 2021
Mitochondria are essential organelles in physiology and kidney diseases, because they produce cellular energy required to perform their function. During mitochondrial metabolism, reactive oxygen species (ROS) are produced.
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, José Pedraza-Chaverri   +3 more
doaj   +1 more source

Molecular Basis of Redox Signaling [PDF]

Oxidative Medicine and Cellular Longevity, 2019
Fil: Hannibal, Luciana.
Maria Clara Franco, Maria C. Carreras, Luciana Hannibal   +2 more
openaire   +3 more sources

Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: proof of concept

npj Microgravity
Skeletal muscles overcome terrestrial, gravitational loading by producing tensile forces that produce movement through joint rotation. Conversely, the microgravity of spaceflight reduces tensile loads in working skeletal muscles, causing an adaptive ...
Khaled Y. Kamal, Mariam Atef Othman, Joo-Hyun Kim, John M. Lawler   +3 more
doaj   +1 more source

Exercise mitigates reductive stress-induced cardiac remodeling in mice

Redox Biology
The endoplasmic reticulum (ER) regulates protein folding and maintains proteostasis in cells. We observed that the ER transcriptome is impaired during chronic reductive stress (RS) in cardiomyocytes.
Arun Jyothidasan, Sini Sunny, Asokan Devarajan, Aniqa Sayed, John Kofi Afortude, Brian Dalley, Vivek Nanda, Steven Pogwizd, Silvio H. Litovsky, Joel D. Trinity, Matthew Might, Namakkal S. Rajasekaran   +11 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Redox regulation of tumor suppressor PTEN in cell signaling

, 2020
Phosphatase and tensin homologs deleted on chromosome 10 (PTEN) is a potent tumor suppressor and often dysregulated in cancers. Cellular PTEN activity is restrained by the oxidation of active -site cysteine by reactive oxygen species (ROS).
우현애
core   +1 more source

Redox Signaling and Cardiac Sarcomeres [PDF]

Journal of Biological Chemistry, 2011
Oxidative stress is common in many clinically important cardiac disorders, including ischemia/reperfusion, diabetes, and hypertensive heart disease. Oxidative stress leads to derangements in pump function due to changes in the expression or function of proteins that regulate intracellular Ca(2+) homeostasis.
Marius P, Sumandea, Susan F, Steinberg
openaire   +2 more sources