Results 21 to 30 of about 176,842 (263)

Sex differences in redox homeostasis in renal disease

Redox Biology, 2020
Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney.
Tanecia Mitchell, Carmen De Miguel, Eman Y. Gohar   +2 more
doaj   +1 more source

Use of Computational Biochemistry for Elucidating Molecular Mechanisms of Nitric Oxide Synthase

Computational and Structural Biotechnology Journal, 2019
Nitric oxide (NO) is an essential signaling molecule in the regulation of multiple cellular processes. It is endogenously synthesized by NO synthase (NOS) as the product of L-arginine oxidation to L-citrulline, requiring NADPH, molecular oxygen, and a ...
Emmanuelle Bignon, Salvatore Rizza, Giuseppe Filomeni, Elena Papaleo   +3 more
doaj   +1 more source

Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling

Frontiers in Physiology, 2017
Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling maintains the redox homeostasis and its activation is shown to suppress cardiac maladaptation.
Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran   +11 more
doaj   +1 more source

Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

Biomolecules, 2021
Mitochondria are essential organelles in physiology and kidney diseases, because they produce cellular energy required to perform their function. During mitochondrial metabolism, reactive oxygen species (ROS) are produced.
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, José Pedraza-Chaverri   +3 more
doaj   +1 more source

Quantitative biology of hydrogen peroxide signaling

Redox Biology, 2017
Hydrogen peroxide (H2O2) controls signaling pathways in cells by oxidative modulation of the activity of redox sensitive proteins denominated redox switches.
Fernando Antunes, Paula Matos Brito
doaj   +1 more source

Reductive stress induces unresolved ER stress and proteotoxic cardiomyopathy

Redox Biology
Chronic reductive stress (cRS), induced by constitutive activation of Nrf2 in transgenic (TG) mouse hearts leads to pathological cardiac remodeling and diastolic dysfunction.
Sini Sunny, Rajesh Kumar Radhakrishnan, Asokan Devarajan, Juan Xavier Masjoan Juncos, Mohit Bansal, Xiaosen Ouyang, Jianhua Zhang, Min Xie, Silvio H. Litovsky, Joel D. Trinity, Matthew Might, Steven M. Pogwizd, Maria I. Kontaridis, Namakkal S. Rajasekaran   +13 more
doaj   +1 more source

Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice

Redox Biology, 2019
Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2/Nrf2) is an inducible transcription factor that is essential for maintenance of redox signaling in response to stress.
Gobinath Shanmugam, Anil Kumar Challa, Silvio H. Litovsky, Asokan Devarajan, Ding Wang, Dean P. Jones, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran   +7 more
doaj   +1 more source

Compartmentalized muscle redox signals controlling exercise metabolism – Current state, future challenges

Redox Biology, 2020
Exercise imposes cellular stress on contracting skeletal muscle fibers, forcing them to complete molecular adaptations to maintain homeostasis. There is mounting evidence that redox signaling by reactive oxygen species (ROS) is vital for skeletal muscle ...
Carlos Henriquez-Olguin, Roberto Meneses-Valdes, Thomas E. Jensen   +2 more
doaj   +1 more source

Redox homeostasis: The Golden Mean of healthy living

Redox Biology, 2016
The notion that electrophiles serve as messengers in cell signaling is now widely accepted. Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as components of maintenance of a normal physiological steady state.
Fulvio Ursini, Matilde Maiorino, Henry Jay Forman   +2 more
doaj   +1 more source

Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: proof of concept

npj Microgravity
Skeletal muscles overcome terrestrial, gravitational loading by producing tensile forces that produce movement through joint rotation. Conversely, the microgravity of spaceflight reduces tensile loads in working skeletal muscles, causing an adaptive ...
Khaled Y. Kamal, Mariam Atef Othman, Joo-Hyun Kim, John M. Lawler   +3 more
doaj   +1 more source