Oxidative modification of proteins: from damage to catalysis, signaling, and beyond [PDF]
, 2021 Significance: The systematic investigation of oxidative modification of proteins by reactive oxygen species started in 1980. Later, it was shown that reactive nitrogen species could also modify proteins.
Gomes, Fernando +25 more
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The Aging Liver: Redox Biology and Liver Regeneration
, 2021 Significance: During aging, excessive production of reactive species in the liver leads to redox imbalance with consequent oxidative damage and impaired organ homeostasis.
Vendemiale, Gianluigi +3 more
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Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise [PDF]
, 2013 Pathological endoplasmic reticulum (ER) stress is tightly linked to the accumulation of reactive oxidants, which can be both upstream and downstream of ER stress.
Julia Birk +15 more
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Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity. [PDF]
, 2022 Memo1 deletion in mice causes premature aging and an unbalanced metabolism partially resembling Fgf23 and Klotho loss-of-function animals. We report a role for Memo's redox function in renal FGF23-Klotho signaling using mice with postnatally induced Memo
Bonny, Olivier +32 more
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Redox Signaling through DNA [PDF]
Israel Journal of Chemistry, 2016 AbstractBiological electron transfer reactions between metal cofactors are critical to many essential processes within the cell. Duplex DNA is, moreover, capable of mediating the transport of charge through its π‐stacked nitrogenous bases. Increasingly, [4Fe4S] clusters, generally redox‐active cofactors, have been found to be associated with enzymes ...
O'Brien, Elizabeth +2 more
openaire +4 more sources
Dynamic plastid redox signals integrate gene expression and metabolism to induce distinct metabolic states in photosynthetic acclimation in Arabidopsis [PDF]
, 2009 Plants possess acclimation responses in which structural reconfigurations adapt the photosynthetic apparatus to fluctuating illumination. Long-term acclimation involves changes in plastid and nuclear gene expression and is controlled by redox signals ...
Dietz, K. +55 more
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A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes
Redox Biology, 2016 Antagonizing TNF-α signaling attenuates chronic inflammatory disease, but is associated with adverse effects on the cardiovascular system. Therefore the impact of TNF-α on basal control of redox signaling events needs to be understand in more depth. This
Gobinath Shanmugam +9 more
doaj +1 more source
Redox Signaling and Stress in Inherited Myopathies
, 2022 Significance: Reactive oxygen species (ROS) are highly reactive compounds that behave like a double-edged sword; they damage cellular structures and act as second messengers in signal transduction.
Sukru Anil Dogan +8 more
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Adipokines and redox signaling: impact on fatty liver disease. [PDF]
, 2011 Adipokines (adipose tissue cytokines) are polypeptide factors secreted by adipose tissue in a highly regulated manner. The 'classical' adipokines (leptin, adiponectin, and resistin) are expressed only by adipocytes, but other adipokines have been shown ...
Marra, Fabio. +2 more
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Peroxiredoxins in Redox Signaling and Aging [PDF]
, 2017 Peroxiredoxins have emerged as conserved modulators of the rate of aging in yeast and multicellular organisms and play a role in lifespan extension through the anti-aging intervention caloric restriction.
Roger, Friederike
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