Results 31 to 40 of about 1,330,295 (302)

Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium

Redox Biology, 2017
Redox homeostasis regulates key cellular signaling pathways in both physiology and pathology. The cell's antioxidant response provides a defense against oxidative stress and establishes a redox tone permissive for cell signaling. The molecular regulation
Gobinath Shanmugam, Madhusudhanan Narasimhan, Susan Tamowski, Victor Darley-Usmar, Namakkal S. Rajasekaran   +4 more
doaj   +1 more source

Sex differences in redox homeostasis in renal disease

Redox Biology, 2020
Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney.
Tanecia Mitchell, Carmen De Miguel, Eman Y. Gohar   +2 more
doaj   +1 more source

Redox‐dependent signal transduction [PDF]

FEBS Letters, 2000
Reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide appear to be transiently produced in response to growth factor and cytokine stimulation. A variety of evidence suggests that this ligand‐stimulated change in the cellular redox state participates in downstream signal transduction.
openaire   +2 more sources

Use of Computational Biochemistry for Elucidating Molecular Mechanisms of Nitric Oxide Synthase

Computational and Structural Biotechnology Journal, 2019
Nitric oxide (NO) is an essential signaling molecule in the regulation of multiple cellular processes. It is endogenously synthesized by NO synthase (NOS) as the product of L-arginine oxidation to L-citrulline, requiring NADPH, molecular oxygen, and a ...
Emmanuelle Bignon, Salvatore Rizza, Giuseppe Filomeni, Elena Papaleo   +3 more
doaj   +1 more source

Dynamic Redox Regulation of IL-4 Signaling. [PDF]

PLoS Computational Biology, 2015
Quantifying the magnitude and dynamics of protein oxidation during cell signaling is technically challenging. Computational modeling provides tractable, quantitative methods to test hypotheses of redox mechanisms that may be simultaneously operative ...
Gaurav Dwivedi, Margaret A Gran, Pritha Bagchi, Melissa L Kemp   +3 more
doaj   +1 more source

Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling

Frontiers in Physiology, 2017
Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling maintains the redox homeostasis and its activation is shown to suppress cardiac maladaptation.
Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran, Namakkal S. Rajasekaran   +11 more
doaj   +1 more source

Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice

Redox Biology, 2019
Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2/Nrf2) is an inducible transcription factor that is essential for maintenance of redox signaling in response to stress.
Gobinath Shanmugam, Anil Kumar Challa, Silvio H. Litovsky, Asokan Devarajan, Ding Wang, Dean P. Jones, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran   +7 more
doaj   +1 more source

Reductive stress impairs myogenic differentiation

Redox Biology, 2020
Myo-satellite cells regenerate and differentiate into skeletal muscle (SM) after acute or chronic injury. Changes in the redox milieu towards the oxidative arm at the wound site are known to compromise SM regeneration.
Namakkal S. Rajasekaran, Sandeep Balu Shelar, Dean P. Jones, John R. Hoidal   +3 more
doaj   +1 more source

Protein tyrosine phosphorylation and protein tyrosine nitration in redox signaling

, 2008
Reversible phosphorylation of protein tyrosine residues by polypeptide growth factor-receptor protein tyrosine kinases is implicated in the control of fundamental cellular processes including the cell cycle, cell adhesion, and cell survival, as well as ...
Travassos, Luiz R. [UNIFESP], Roberto J. Arai, Luiz R. Travassos, Arai, Roberto J. [UNIFESP], Monteiro, Hugo P. [UNIFESP], Hugo P. Monteiro   +5 more
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Reductive stress induces unresolved ER stress and proteotoxic cardiomyopathy

Redox Biology
Chronic reductive stress (cRS), induced by constitutive activation of Nrf2 in transgenic (TG) mouse hearts leads to pathological cardiac remodeling and diastolic dysfunction.
Sini Sunny, Rajesh Kumar Radhakrishnan, Asokan Devarajan, Juan Xavier Masjoan Juncos, Mohit Bansal, Xiaosen Ouyang, Jianhua Zhang, Min Xie, Silvio H. Litovsky, Joel D. Trinity, Matthew Might, Steven M. Pogwizd, Maria I. Kontaridis, Namakkal S. Rajasekaran   +13 more
doaj   +1 more source