Results 61 to 70 of about 187,466 (308)

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Targeting Oncogenic Nuclear Factor Kappa B Signaling with Redox-Active Agents for Cancer Treatment

, 2018
Significance: Nuclear factor kappa B (NF-κB) signaling is essential under physiologically relevant conditions. However, aberrant activation of this pathway plays a pertinent role in tumorigenesis and contributes to resistance.
Zaklina Kovacevic, Fouani, Leyla, Leyla Fouani, Kovacevic, Zaklina, Richardson, Des R, Des R. Richardson   +5 more
core   +1 more source

Cytosolic cysteine in redox signaling [PDF]

Plant Signaling & Behavior, 2008
CYSTEINE BIOSYNTHESIS IN PLANTS TAKES PLACE IN THE THREE CELLULAR COMPARTMENTS WITH AUTONOMOUS PROTEIN BIOSYNTHESIS MACHINERY: cytosol, plastids and mitochondria. This sulfur-containing molecule is synthesized sequentially in these compartments by two enzymatic families, the serine acetyltransferases and the O-acetylserine(thiol) lyases.
López-Martín, M. Carmen, Romero, Luis C., Gotor, Cecilia   +2 more
openaire   +3 more sources

Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation

Frontiers in Aging Neuroscience, 2020
Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein
Mattéa J. Finelli
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Monolayer to MTS : using SEM, HIM, TEM and SERS to compare morphology, nanosensor uptake and redox potential in MCF7 cells

, 2015
This research received support from the QNano Project http://www.qnano-ri.eu which is financed by the European Community Research Infrastructures under the FP7 Capacities Programme (Grant No.
Campbell, C.J., C. J. Campbell, Bell, A.P., A. P. Bell, Jamieson, L.E., Harrison, D.J., L. E. Jamieson, D. J. Harrison   +7 more
core   +1 more source

Cell Compartmentalization in Redox Signaling [PDF]

IUBMB Life, 2001
AbstractFrom a growing body of evidence on the role of Reactive Oxygen Species as intracellular signaling molecules, the concept starts to emerge that cell responses to redox changes are function of the intracellular site where oxidants are produced and/or meet their molecular targets.
G, Pani, B, Bedogni, R, Colavitti, R, Anzevino, S, Borrello, T, Galeotti   +5 more
openaire   +2 more sources

Novel and Converging Ways of NOX2 and SOD3 in Trafficking and Redox Signaling in Macrophages

Antioxidants, 2021
Macrophages and related tissue macrophage populations use the classical NADPH oxidase (NOX2) for the regulated production of superoxide and derived oxidants for pathogen combat and redox signaling.
Steen Vang Petersen, Nanna Bach Poulsen, Cecilie Linneberg Matthiesen, Frederik Vilhardt   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The C-Terminal Module IV of Connective Tissue Growth Factor, Through EGFR/Nox1 Signaling, Activates the NF-κB Pathway and Proinflammatory Factors in Vascular Smooth Muscle Cells

, 2015
Connective tissue growth factor (CTGF/CCN2) is a developmental gene upregulated in pathological conditions, including cardiovascular diseases, whose product is a matricellular protein that can be degraded to biologically active fragments. Among them, the
Rodrigues-Diez, Raul R., Keri, Gyorgy, Egido de los Ríos, Jesús, Gyorgy Kery, Briones Alonso, Ana María, Pato, Janos, Raúl R. Rodrigues-Diez, Jesus Egido, Ana Belen Garcia-Redondo, Macarena Orejudo, Enrique Bosch-Panadero, Rodrigues Díez, Raquel, Salaices Sánchez, Mercedes, Ruiz Ortega, Marta, Raquel Rodrigues-Diez, Marta Ruiz-Ortega, Janos Pato, Orejudo, Macarena, Bosch-Panadero, Enrique, Mercedes Salaices, Alberto Ortiz, Ortiz Arduán, Alberto, Ana Maria Briones, García Redondo, Ana Belén   +23 more
core   +1 more source