Results 61 to 70 of about 1,330,295 (302)

Redox Biology

, 2017
The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades.
Idelchik, Maria del Pilar Sosa, Melendez, J. Andrés, Chandrasekaran, Akshaya   +2 more
core   +1 more source

Reactive Oxygen Species and Redox Signaling in Chronic Kidney Disease

, 2020
Chronic kidney disease (CKD) remains a worldwide public health problem associated with serious complications and increased mortality rates. Accumulating evidence indicates that elevated intracellular levels of reactive oxygen species (ROS) play a major ...
Vicente E. Torres, Maria V. Irazabal
core   +1 more source

Redox regulation of the NPR1-TGA1 system of Arabidopsis thaliana by nitric oxide [PDF]

, 2010
The role of reactive oxygen and nitrogen species in local and systemic defense reactions is well documented. NPR1 and TGA1 are key redox-controlled regulators of systemic acquired resistance in plants. NPR1 monomers interact with the reduced form of TGA1,
Bernd Müller, Leister, Dario, Jörg Durner, Leister, D., Durner, J., Durner, Jörg, Christian Lindermayr, Lindermayr, C., Sell, S., Lindermayr, Christian, Dario Leister, Sell, Simone, Müller, B., Müller, Bernd, Simone Sell   +14 more
core   +1 more source

Metabolic and redox signaling in the retina [PDF]

Cellular and Molecular Life Sciences, 2016
Visual perception by photoreceptors relies on the interaction of incident photons from light with a derivative of vitamin A that is covalently linked to an opsin molecule located in a special subcellular structure, the photoreceptor outer segment.
Léveillard, Thierry, Sahel, José-Alain
openaire   +4 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Redox signaling in the gastrointestinal tract

Free Radical Biology and Medicine, 2017
Redox signaling regulates physiological self-renewal, proliferation, migration and differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch signaling pathways mainly through NADPH oxidases (NOXs). In the intestine, intracellular and extracellular thiol redox status modulates the proliferative potential of epithelial cells ...
Pérez Garrido, Salvador, Taléns Visconti, Raquel, Rius Pérez, Sergio, Andres Finamor, Isabela, Sastre Belloch, Juan   +4 more
openaire   +3 more sources

HyPer as a tool to determine the reductive activity in cellular compartments

Redox Biology
A multitude of cellular metabolic and regulatory processes rely on controlled thiol reduction and oxidation mechanisms. Due to our aerobic environment, research preferentially focuses on oxidation processes, leading to limited tools tailored for ...
Andrei Zhuravlev, Daria Ezeriņa, Julia Ivanova, Nikita Guriev, Natalia Pugovkina, Alla Shatrova, Nikolay Aksenov, Joris Messens, Olga Lyublinskaya   +8 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation

Frontiers in Aging Neuroscience, 2020
Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein
Mattéa J. Finelli
doaj   +1 more source