Results 71 to 80 of about 187,466 (308)

Redox signaling in cardiac myocytes

Free Radical Biology and Medicine, 2011
The heart has complex mechanisms that facilitate the maintenance of an oxygen supply-demand balance necessary for its contractile function in response to physiological fluctuations in workload as well as in response to chronic stresses such as hypoxia, ischemia, and overload.
Xavier Da Costa Dos Santos, Celio Santos, Anilkumar, Narayana, Zhang, Min, Brewer, Alison C., Shah, Ajay M.   +4 more
openaire   +3 more sources

Redox Regulation of Lymphocyte Signaling [PDF]

IUBMB Life, 2000
AbstractCompelling evidence exists that reactive oxygen species can deliver intracellular signals in mammalian cells, and elicit a broad array of physiological responses according to the cell type, the oxidative burden and the cellular compartment where radicals are generated. When applied to immune cells, these concepts gain a particular relevance, in
G, Pani, R, Colavitti, S, Borrello, T, Galeotti   +3 more
openaire   +2 more sources

HyPer as a tool to determine the reductive activity in cellular compartments

Redox Biology
A multitude of cellular metabolic and regulatory processes rely on controlled thiol reduction and oxidation mechanisms. Due to our aerobic environment, research preferentially focuses on oxidation processes, leading to limited tools tailored for ...
Andrei Zhuravlev, Daria Ezeriņa, Julia Ivanova, Nikita Guriev, Natalia Pugovkina, Alla Shatrova, Nikolay Aksenov, Joris Messens, Olga Lyublinskaya   +8 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Redox regulation of tumor suppressor PTEN in cell signaling

, 2020
Phosphatase and tensin homologs deleted on chromosome 10 (PTEN) is a potent tumor suppressor and often dysregulated in cancers. Cellular PTEN activity is restrained by the oxidation of active -site cysteine by reactive oxygen species (ROS).
우현애
core   +1 more source

RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cells

Frontiers in Oncology, 2022
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a poor response to current treatment regimens. The multifunctional DNA repair-redox signaling protein Ref-1 has a redox signaling function that activates several transcriptional
Mahmut Mijit, Randall Wireman, Lee Armstrong, Silpa Gampala, Zonera Hassan, Christian Schneeweis, Guenter Schneider, Chi Zhang, Chi Zhang, Chi Zhang, Melissa L. Fishel, Melissa L. Fishel, Melissa L. Fishel, Mark R. Kelley, Mark R. Kelley, Mark R. Kelley, Mark R. Kelley   +16 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Redox signaling in drug-tolerant persister cells as an emerging therapeutic target

EBioMedicine, 2023
Summary: Drug-tolerant persister (DTP) cells have attracted significant interest, given their predominant role in treatment failure. In this respect, DTP cells reportedly survive after anticancer drug exposure, and their DNA repair mechanisms are altered
Zhe Zhang, Yunhan Tan, Canhua Huang, Xiawei Wei   +3 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Mitochondria and Redox Signaling in Steatohepatitis [PDF]

Antioxidants & Redox Signaling, 2011
Alcoholic and nonalcoholic fatty liver diseases are potentially pathological conditions that can progress to steatohepatitis, fibrosis, and cirrhosis. These conditions affect millions of people throughout the world in part through poor lifestyle choices of excess alcohol consumption, overnutrition, and lack of regular physical activity.
E Matthew, Morris, R Scott, Rector, John P, Thyfault, Jamal A, Ibdah   +3 more
openaire   +2 more sources