Results 11 to 20 of about 125,831 (393)
Biochimie, 2013 Peroxisomes are essential organelles in higher eukaryotes as they play a major role in numerous metabolic pathways and redox homeostasis. Some peroxisomal abnormalities, which are often not compatible with life or normal development, were identified in ...
Geillon, Flore +7 more
core +7 more sources
VPS13D bridges the ER to mitochondria and peroxisomes via Miro
Journal of Cell Biology, 2021 VPS13D mutations result in severe mitochondrial defects. Guillén-Samander et al. show that VPS13D binds VAP in the ER and interacts with Miro on mitochondria and peroxisomes, where it could provide a bridge for lipid transport between these organelles.
Andrés Guillén-Samander +5 more
semanticscholar +1 more source
Calcium in peroxisomes: An essential messenger in an essential cell organelle
Frontiers in Cell and Developmental Biology, 2022 Calcium is a central signal transduction element in biology. Peroxisomes are essential cellular organelles, yet calcium handling in peroxisomes has been contentious.
Yelena Sargsyan +5 more
doaj +1 more source
The proteome of human liver peroxisomes: identification of five new peroxisomal constituents by a label-free quantitative proteomics survey. [PDF]
PLoS ONE, 2013 The peroxisome is a key organelle of low abundance that fulfils various functions essential for human cell metabolism. Severe genetic diseases in humans are caused by defects in peroxisome biogenesis or deficiencies in the function of single peroxisomal ...
Thomas Gronemeyer +12 more
doaj +1 more source
The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.) [PDF]
, 2014 The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of ...
C Achmüller +36 more
core +11 more sources
Emerging nanomaterials for targeting peroxisomes
Materials Today Advances, 2022 Peroxisomes are single membrane-bound metabolic organelles whose dysfunction can lead to several metabolic disorders. In addition, they have been associated with the pathology of several diseases such as cancer, autoimmune diseases, diabetes, stroke, etc.
Akash Bachhuka +5 more
doaj +1 more source
Peroxisomal Membrane Contact Sites in Yeasts
Frontiers in Cell and Developmental Biology, 2021 Peroxisomes are ubiquitous, single membrane-bound organelles that play a crucial role in lipid metabolism and human health. While peroxisome number is maintained by the division of existing peroxisomes, nascent peroxisomes can be generated from the ...
Amit S. Joshi
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Monoterpenoids, monoterpene indole alkaloids, and cannabinoids are highly valued for their fragrant and therapeutic properties, but sourcing them from nature or deriving them from petrochemicals is no longer sustainable. However, sustainable
Simon Dusséaux +4 more
semanticscholar +1 more source
A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells
iScience, 2020 Summary: Peroxisomes are metabolic organelles that perform a diverse array of critical functions in human physiology. Traditional isolation methods for peroxisomes can take more than 1 h to complete and can be laborious to implement.
G. Jordan Ray +6 more
doaj +1 more source