Results 21 to 30 of about 34,934 (252)

Hansenula polymorpha: An attractive model organism for molecular studies of peroxisome biogenesis and function [PDF]

, 1992
In wild-type Hansenula polymorpha the proliferation of peroxisomes is induced by various unconventional carbon- and nitrogen sources. Highest induction levels, up to 80% of the cytoplasmic volume, are observed in cells grown in methanol-limited chemostat
Titorenko, V.,, Titorenko, V., Klei, I.J. van der; id_orcid, Klei, I.J. van der,, Veenhuis, M., Harder, W.,, Klei, I.J. van der, Veenhuis, M.,, Harder, W.   +8 more
core   +2 more sources

Peroxisomes and disease - an overview. [PDF]

, 2006
Peroxisomes are indispensable for human health and development. They represent ubiquitous subcellular organelles which compartmentalize enzymes responsible for several crucial metabolic processes such as β-oxidation of specific fatty acids, biosynthesis ...
M Schrader (16286), NA Bonekamp (21832802), HK Delille (21854150)   +2 more
core   +6 more sources

Peroxisome Synthesis in the Absence of Preexisting Peroxisomes [PDF]

The Journal of Cell Biology, 1999
Zellweger syndrome and related diseases are caused by defective import of peroxisomal matrix proteins. In all previously reported Zellweger syndrome cell lines the defect could be assigned to the matrix protein import pathway since peroxisome membranes were present, and import of integral peroxisomal membrane proteins was normal.
S T, South, S J, Gould
openaire   +2 more sources

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Ida J. van der Klei, Loknath Gidijala, Kiel, Jan A. K. W., Gidijala, Loknath, Klei, Ida J. van der,, van der Klei, Ida J., Jan A.K.W. Kiel, Veenhuis, Marten,, Gidijala, Loknath,, Kiel, Jan A.K.W.,, Marten Veenhuis, Veenhuis, Marten, van der Klei, Ida J.; id_orcid   +12 more
core   +2 more sources

Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]

, 2012
Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Kikhney, Alexey, Roermund, Carlo W.T. van,, van Roermund, C. W. T., Opalinski, L., Kikhney, A., Williams, Chris,, de Boer, R., Veenhuis, Marten, Kikhney, Alexey,, de Boer, Rinse, Williams, C., Williams, Chris, Opalinski, Lukasz, Bartoszewska, M., Klei, Ida J. van der,, van der Klei, Ida J., Boer, Rinse de,, Opaliński, Łukasz,, van der Klei, I. J., van Roermund, Carlo W. T., Veenhuis, Marten,, Veenhuis, M., van der Klei, Ida J.; id_orcid, Bartoszewska, Magdalena, Bartoszewska, Magdalena,   +24 more
core   +3 more sources

Emerging nanomaterials for targeting peroxisomes

, 2022
Peroxisomes are single membrane-bound metabolic organelles whose dysfunction can lead to several metabolic disorders. In addition, they have been associated with the pathology of several diseases such as cancer, autoimmune diseases, diabetes, stroke, etc.
Bachhuka, A., Marsal, L.F., Ergün, S., Karnati, S., Chand Yadav, T., Santos, A.   +5 more
core   +2 more sources

No peroxisome is an island — Peroxisome contact sites

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016
In order to optimize their multiple cellular functions, peroxisomes must collaborate and communicate with the surrounding organelles. A common way of communication between organelles is through physical membrane contact sites where membranes of two organelles are tethered, facilitating exchange of small molecules and intracellular signaling.
Shai, Nadav, Schuldiner, Maya, Zalckvar, Einat   +2 more
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Peroxisomes and peroxisomal disorders: The main facts [PDF]

Experimental and Toxicologic Pathology, 2010
The importance of peroxisomes for human health is highlighted by the number of peroxisomal disorders (PDs), diseases associated to peroxisome biogenesis disorders and peroxisomal enzyme/transporter deficiencies. Currently, many physiological/biosynthetic mechanisms involved in these illnesses have been elucidated, but PDs remain incurable.
openaire   +3 more sources

Plant peroxisomes: protein import, dynamics and metabolite transport

, 2013
Peroxisomes are small organelles that play pivotal roles in a variety of metabolic processes in eukaryotic cells. In plants, peroxisomes are essential for viability and influence growth and development due to their contributions to processes such as ...
Kaur, N., Jianping Hu, Theodoulou, F. L., Alison Baker, Navneet Kaur, Hu, J., Laura Cross, Frederica L. Theodoulou, Cross, L., Baker, A.   +9 more
core   +1 more source