Results 21 to 30 of about 6,872 (253)

Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif

Viruses, 2022
Flaviviruses such as dengue virus (DENV) and Zika virus (ZIKV) have evolved sophisticated mechanisms to suppress the host immune system. For instance, flavivirus infections were found to sabotage peroxisomes, organelles with an important role in innate ...
Mafalda A. Farelo, Despoina Korrou-Karava, Katrina F. Brooks, Tiffany A. Russell, Kevin Maringer, Peter U. Mayerhofer   +5 more
doaj   +1 more source

Peroxisome Synthesis in the Absence of Preexisting Peroxisomes [PDF]

The Journal of Cell Biology, 1999
Zellweger syndrome and related diseases are caused by defective import of peroxisomal matrix proteins. In all previously reported Zellweger syndrome cell lines the defect could be assigned to the matrix protein import pathway since peroxisome membranes were present, and import of integral peroxisomal membrane proteins was normal.
S T, South, S J, Gould
openaire   +2 more sources

Hansenula polymorpha: An attractive model organism for molecular studies of peroxisome biogenesis and function [PDF]

, 1992
In wild-type Hansenula polymorpha the proliferation of peroxisomes is induced by various unconventional carbon- and nitrogen sources. Highest induction levels, up to 80% of the cytoplasmic volume, are observed in cells grown in methanol-limited chemostat
Titorenko, V.,, Titorenko, V., Klei, I.J. van der; id_orcid, Klei, I.J. van der,, Veenhuis, M., Harder, W.,, Klei, I.J. van der, Veenhuis, M.,, Harder, W.   +8 more
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Phytanic acid oxidation: topographical localization of phytanoyl-CoA ligase and transport of phytanic acid into human peroxisomes.

Journal of Lipid Research, 1995
To understand the possible role of phytanoyl-CoA ligase, present in the membrane, in the oxidation of phytanic acid in the matrix of peroxisomes (Pahan, K. and I. Singh. 1993. FEBS Lett.
K Pahan, I Singh
doaj   +1 more source

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Ida J. van der Klei, Loknath Gidijala, Kiel, Jan A. K. W., Gidijala, Loknath, Klei, Ida J. van der,, van der Klei, Ida J., Jan A.K.W. Kiel, Veenhuis, Marten,, Gidijala, Loknath,, Kiel, Jan A.K.W.,, Marten Veenhuis, Veenhuis, Marten, van der Klei, Ida J.; id_orcid   +12 more
core   +1 more source

Peroxisomes: Organelles at the crossroads [PDF]

Trends in Cell Biology, 1997
Recent years have seen remarkable progress in our understanding of the function of peroxisomes in higher and lower eukaryotes. Combined genetic and biochemical approaches have led to the identification of many genes required for the biogenesis of this organelle.
Erdmann, R, Veenhuis, M, Kunau, WH, Kunau, Wolf-H.   +3 more
openaire   +4 more sources

The subset of peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved.

PLoS ONE, 2023
Peroxisomes are membrane-enclosed organelles with important roles in fatty acid breakdown, bile acid synthesis and biosynthesis of sterols and ether lipids. Defects in peroxisomes result in severe genetic diseases, such as Zellweger syndrome and neonatal
Tamara Somborac, Güleycan Lutfullahoglu Bal, Kaneez Fatima, Helena Vihinen, Anja Paatero, Eija Jokitalo, Ville O Paavilainen, Svetlana Konovalova   +7 more
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Rosy Beginnings: Studying Peroxisomes in Drosophila

Frontiers in Cell and Developmental Biology, 2020
Research using the fruit fly Drosophila melanogaster has traditionally focused on understanding how mutations affecting gene regulation or function affect processes linked to animal development.
C. Pridie, Kazuki Ueda, Andrew J. Simmonds   +2 more
doaj   +1 more source

Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]

, 2012
Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Kikhney, Alexey, Roermund, Carlo W.T. van,, van Roermund, C. W. T., Opalinski, L., Kikhney, A., Williams, Chris,, de Boer, R., Veenhuis, Marten, Kikhney, Alexey,, de Boer, Rinse, Williams, C., Williams, Chris, Opalinski, Lukasz, Bartoszewska, M., Klei, Ida J. van der,, van der Klei, Ida J., Boer, Rinse de,, Opaliński, Łukasz,, van der Klei, I. J., van Roermund, Carlo W. T., Veenhuis, Marten,, Veenhuis, M., van der Klei, Ida J.; id_orcid, Bartoszewska, Magdalena, Bartoszewska, Magdalena,   +24 more
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The impact of peroxisomes on cellular ageing and death

Frontiers in Oncology, 2012
Peroxisomes are ubiquitous eukaryotic organelles, which perform a plethora of functions including hydrogen peroxide metabolism and β-oxidation of fatty acids.
Selvambigai eManivannan, Christian Quintus Scheckhuber, Marten eVeenhuis, Ida Joanna van der Klei   +3 more
doaj   +1 more source