Results 11 to 20 of about 34,934 (252)

USP30-Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease. [PDF]

Adv Sci (Weinh)
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Li J, Hua C, Li G, Zhai F, Ren J, Pan S, Feng Q, Wen J, Liu D, Liu Z, Duan J.   +10 more
europepmc   +2 more sources

Exploiting peroxisomes [PDF]

Nature Reviews Microbiology, 2018
exaly   +3 more sources

Brain peroxisomes [PDF]

Biochimie, 2014
Peroxisomes are essential organelles in higher eukaryotes as they play a major role in numerous metabolic pathways and redox homeostasis. Some peroxisomal abnormalities, which are often not compatible with life or normal development, were identified in severe demyelinating and neurodegenerative brain diseases.
Trompier, Doriane, Vejux, A., Zarrouk, A., Gondcaille, Catherine, Geillon, Flore, Nury, T., Savary, Stéphane, Lizard, Gérard   +7 more
openaire   +4 more sources

Peroxisomes in parasitic protists

, 2016
Representatives of all major lineages of eukaryotes contain peroxisomes with similar morphology and mode of biogenesis, indicating a monophyletic origin of the organelles within the common ancestor of all eukaryotes.
Gabaldón, Toni, Ginger, Michael Louis, Michels, Paul A. M.   +2 more
core   +5 more sources

A Study on the Origin of Peroxisomes: Possibility of Actinobacteria Symbiosis [PDF]

, 2008
The origin of peroxisomes as having developed from the endoplasmic reticulum (ER) was proposed on the basis of the similarity between some peroxisomal proteins and ER proteins, and the localization of some peroxisomal proteins on the ER.
Miyata Daisuke, Horiike Tokumasa, Saruhashi Satoshi, Hamada Kazuo, Shinozawa Takao, Duhita Narendra   +5 more
core   +1 more source

Peroxisomes in intestinal and gallbladder epithelial cells of the stickleback, Gasterosteus aculeatus L. (Teleostei) [PDF]

, 1988
The occurrence of microbodies in the epithelial cells of the intestine and gallbladder of the stickleback, Gasterosteus aculeatus L., is described. In the intestine the organelles are predominantly located in the apical and perinuclear zone of the cells ...
Ruiter, A.J.H. de,, Ruiter, A.J.H. de, Wendelaar Bonga, S.E., Veenhuis, M., Veenhuis, M.,, Wendelaar Bonga, S.E.,   +5 more
core   +2 more sources

Pmp27 Promotes Peroxisomal Proliferation [PDF]

, 1995
Peroxisomes perform many essential functions in eukaryotic cells. The weight of evidence indicates that these organelles divide by budding from preexisting peroxisomes. This process is not understood at the molecular level.
J M Goodman, Lark, Richard H.,, Krimkevich,, Y. I., Y I Krimkevich, J M Dyer, P A Marshall, Goodman, J. M., M Veenhuis, Krimkevich, Yelena I.,, Veenhuis, Marten,, Dyer, J. M., Veenhuis, M., Marshall, Pamela A.,, Goodman, Joel M.,, Lark, R. H., Dyer, John M.,, Marshall, P. A., R H Lark   +17 more
core   +2 more sources

Pay32p of the Yeast Yarrowia lipolytica Is an Intraperoxisomal Component of the Matrix Protein Translocation Machinery [PDF]

, 1995
Pay mutants of the yeast Yarrowia lipolytica fail to assemble functional peroxisomes. One mutant strain, pay32-1, has abnormally small peroxisomes that are often found in clusters surrounded by membranous material.
Rachubinski, Richard A., Szilard, Rachel K., Rachubinski, Richard A.,, Titorenko, Vladimir I.,, V I Titorenko, R A Rachubinski, Titorenko, Vladimir I., Rachel K. Szilard, M Veenhuis, Veenhuis, Marten,, R K Szilard, Szilard, Rachel K.,, Richard A. Rachubinski, Marten Veenhuis, Veenhuis, Marten, Vladimir I. Titorenko   +15 more
core   +2 more sources

A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae [PDF]

, 2001
In vivo time-lapse microscopy reveals that the number of peroxisomes in Saccharomyces cerevisiae cells is fairly constant and that a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process.
Marlene van den Berg, Hettema, E.H., Peter Philippsen, Henk F. Tabak, Hoepfner, D., Tabak, H.F., Dominic Hoepfner, Tabak, H. F., Hettema, E. H., Ewald H. Hettema, van den Berg, M., Philippsen, P.   +11 more
core   +2 more sources

Peroxisomes: Organelles at the crossroads [PDF]

Trends in Cell Biology, 1997
Recent years have seen remarkable progress in our understanding of the function of peroxisomes in higher and lower eukaryotes. Combined genetic and biochemical approaches have led to the identification of many genes required for the biogenesis of this organelle.
Erdmann, R, Veenhuis, M, Kunau, WH, Kunau, Wolf-H.   +3 more
openaire   +4 more sources