Results 121 to 130 of about 184,353 (290)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Latent profile analysis of person⁃environment fit creativity of clinical healthcare workers and its influencing factors

open access: yesHuli yanjiu
ObjectiveTo explore the latent profiles of person⁃environment fit creativity among healthcare workers and to analyze the characteristic differences and influencing factors across these profiles.MethodsA total of 492 healthcare workers from four tertiary ...
NI Ling   +7 more
doaj  

Project DECIDE, part II: decision-making places for people with dementia in Alzheimer's disease: supporting advance decision-making by improving person-environment fit. [PDF]

open access: yesBMC Med Ethics, 2023
Florack J   +20 more
europepmc   +1 more source

Mismatch between entrepreneurs and their firms: the role of cognitive fit / misfit [PDF]

open access: yes
(WP 10/04 Clave pdf) This paper examines the relationship between cognitive fit/misfit, and burnout, satisfaction, and intentions to exit the firm in entrepreneurs.
JULIO ORLANDO DE CASTRO
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Enhancing Employer Attractiveness: the impact of inclusive leadership on prospective employees’ intention to apply

open access: yesCogent Business & Management
This study delves into the intricate dynamics among inclusive leadership (IL), perceived organizational justice (POJ), person-environment fit, employer attractiveness (EA), psychological empowerment (PE) and intention to apply, highlighting mediating and
Md. Abu Issa Gazi   +7 more
doaj   +1 more source

Values congruence and commitment: throwing the role of psychological climate into the mix

open access: yes, 2012
Studying the fit between employees and their organisations and the individual and organisational outcomes of this congruence has been an interesting topic for researchers over the past decades. However, the literature does not adequately address how this
Abdelmoteleb, Samir
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Tackling assumptions and expectations; implementing technology in higher education

open access: yes, 2014
This paper explores the underpinning concepts commonly associated with technological implementation in Higher Education. Technological implementation in Higher Education is driven by assumptions from earlier work exploring the potential demands of the ...
Taylor, Teri
core  

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