Results 11 to 20 of about 444 (152)

Hydrogen Sulfide Signaling in Plants: Emerging Roles of Protein Persulfidation [PDF]

Frontiers in Plant Science, 2018
Hydrogen sulfide (H2S) has been largely referred as a toxic gas and environmental hazard, but recent years, it has emerged as an important gas-signaling molecule with effects on multiple physiological processes in both animal and plant systems.
Angeles Aroca, Cecilia Gotor, Luis C. Romero   +2 more
doaj   +4 more sources

Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1 [PDF]

Redox Biology
Ectopic fat deposition in skeletal muscle (SKM) due to obesity leads to biochemical and morphological alterations that deteriorate SKM quality and performance.
M. Smimmo, V. Casale, D. D'Andrea, I. Bello, N. Iaccarino, F. Romano, V. Brancaleone, E. Panza, R. d’Emmanuele di Villa Bianca, A. Katsouda, E. Mitidieri, I. Antoniadou, A. Papapetropoulos, F. Maione, S. Castaldo, M. Friuli, A. Romano, S. Gaetani, R. Sorrentino, A. Randazzo, G. Cirino, M. Bucci, M. Filipovic, V. Vellecco   +23 more
doaj   +4 more sources

Harshly Oxidized Activated Charcoal Enhances Protein Persulfidation with Implications for Neurodegeneration as Exemplified by Friedreich’s Ataxia

Nanomaterials
Harsh acid oxidation of activated charcoal transforms an insoluble carbon-rich source into water-soluble, disc structures of graphene decorated with multiple oxygen-containing functionalities. We term these pleiotropic nano-enzymes as “pleozymes”.
Anh T. T. Vo, Uffaf Khan, Anton V. Liopo, Karthik Mouli, Kenneth R. Olson, Emily A. McHugh, James M. Tour, Madhavan Pooparayil Manoj, Paul J. Derry, Thomas A. Kent   +9 more
doaj   +2 more sources

The Combined Partial Knockdown of CBS and MPST Genes Induces Inflammation, Impairs Adipocyte Function-Related Gene Expression and Disrupts Protein Persulfidation in Human Adipocytes

Antioxidants, 2022
Recent studies in mice and humans demonstrated the relevance of H2S synthesising enzymes, such as CTH, CBS, and MPST, in the physiology of adipose tissue and the differentiation of preadipocyte into adipocytes.
Jessica Latorre, Angeles Aroca, José Manuel Fernández-Real, Luis C. Romero, José María Moreno-Navarrete   +4 more
doaj   +2 more sources

Ethylene-Induced Hydrogen Sulfide Negatively Regulates Ethylene Biosynthesis by Persulfidation of ACO in Tomato Under Osmotic Stress [PDF]

Frontiers in Plant Science, 2018
A number of recent studies identified hydrogen sulfide (H2S) as an important signal in plant development and adaptation to environmental stress. H2S has been proven to participate in ethylene-induced stomatal closure, but how the signaling pathways of ...
Honglei Jia, Honglei Jia, Sisi Chen, Dan Liu, Johannes Liesche, Cong Shi, Juan Wang, Meijuan Ren, Xiaofeng Wang, Jun Yang, Wei Shi, Jisheng Li   +11 more
doaj   +2 more sources

Persulfidation of Human Cystathionine γ-Lyase Inhibits Its Activity: A Negative Feedback Regulation Mechanism for H₂S Production

Antioxidants
Cystathionine γ-lyase (CSE) is the second enzyme in the trans-sulfuration pathway that converts cystathionine to cysteine. It is also one of three major enzymes responsible for the biosynthesis of hydrogen sulfide (H2S).
Guanya Jia, Heng Li, Haisheng Gan, Jun Wang, Zhilong Zhu, Yanxiong Wang, Yongyi Ye, Xiaoya Shang, Weining Niu   +8 more
doaj   +2 more sources

Reactive Sulfur Species and Protein Persulfidation: An Emerging Redox Axis in Human Health and Disease

Current Issues in Molecular Biology
Reactive sulfur species (RSS)—hydrogen sulfide (H2S), low-molecular-weight persulfides/polysulfides and protein persulfidation—constitute a third redox axis alongside ROS and RNS.
Celia María Curieses Andrés, Fernando Lobo, José Manuel Pérez de la Lastra, Elena Bustamante Munguira, Celia Andrés Juan, Eduardo Pérez Lebeña   +5 more
doaj   +2 more sources

Persulfides and the cellular thiol landscape [PDF]

Proceedings of the National Academy of Sciences, 2014
The biochemistry of sulfur touches on every aspect of cellular biology, from protein structure and function to redox regulation to defense against chemical stress. Over the last decade, posttranslational modification of protein thiols by reactive oxygen or nitrogen species has emerged as a major component of signal transduction, leading to both ...
Miranda, Katrina M., Wink, David A.
openaire   +4 more sources

Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers

Angewandte Chemie, 2022
AbstractProtein persulfides (R‐S‐SH) have emerged as a common post‐translational modification. Detection and quantitation of protein persulfides requires trapping with alkylating agents. Here we show that alkylating agents differ dramatically in their ability to conserve the persulfide's sulfur–sulfur bond for subsequent detection by mass spectrometry.
Danny Schilling, Uladzimir Barayeu, Raphael R. Steimbach, Deepti Talwar, Aubry K. Miller, Tobias P. Dick   +5 more
openaire   +2 more sources

Persulfidation of DJ-1 : Mechanism and Consequences

Biomolecules, 2022
Abstract DJ-1 (also called PARK7) is a ubiquitously expressed protein involved in the etiology of Parkinson disease and cancers. At least one of its three cysteine residue is functionally essential, and its oxidation state determines the specific function of the enzyme.
Erwan Galardon, Nicolas Mathas, Dominique Padovani, Laurent Le Corre, Gabrielle Poncet, Julien Dairou   +5 more
openaire   +3 more sources