Results 61 to 70 of about 444 (152)

Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells

Neoplasia: An International Journal for Oncology Research, 2021
Increased xCT and transsulfuration pathway has been associated with metabolic reprogramming of colorectal cancer. However, the correlation between these 2 events and the underlying molecular mechanism remains obscure.
Shanwen Chen, Dingfang Bu, Jing Zhu, Taohua Yue, Shihao Guo, Xin Wang, Yisheng Pan, Yucun Liu, Pengyuan Wang   +8 more
doaj   +1 more source

Sulfide promotes tolerance to drought through protein persulfidation in Arabidopsis

, 2023
Hydrogen sulfide (H2S) is a signaling molecule that regulates essential plant processes. In this study, the role of H2S during drought was analysed, focusing on the underlying mechanism.
Cecilia Gotor, Ana Jurado-Flores, Romero, Luis C., Angeles Aroca, Jurado-Flores, Ana, Aroca, Angeles, Luis C Romero, Gotor, Cecilia   +7 more
core   +2 more sources

Functional S-persulfidation exploration reveals a novel regulatory mechanism of HNF1α

Redox Biology
Protein S-persulfidation, a post-translational modification mediated by hydrogen sulfide (H2S), plays an essential role in regulating protein function. However, current profiling methods, mainly based on liquid chromatography-tandem mass spectrometry (LC-
Yaqian Huang, Zongmin Li, Shuai Wang, Yuan Wang, Wei Li, Hanlin Peng, Li Wang, Lulu Zhang, Selena Chen, Jing Wang, Dingfang Bu, Heng Zhang, Changting Cui, Qinghua Cui, Bin Geng, Jichun Yang, Nan Chen, Chu Wang, Ming Chu, Chaoshu Tang, Junbao Du, Jingyuan Li, Hongfang Jin   +22 more
doaj   +1 more source

Genetic Links Between Hydrogen Sulfide Pathways and Risk of Alzheimer's Disease and Related Risk Factors: A Phenome‐Wide Approach

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Hydrogen sulfide (H2S) is a promising therapeutic drug target for various pathologies, including Alzheimer's disease (AD) and related dementias (ADRD). The newly recognized gasotransmitter freely permeates cellular membranes and is vital to maintaining homeostasis, primarily via smooth muscle relaxation and vasodilatory mechanisms ...
James J.R. Brady, William R. Reay
wiley   +1 more source

Effect of 3‐mercaptopyruvate sulfurtransferase (3‐MST) inhibitors on contractile responses in porcine coronary artery

British Journal of Pharmacology, Volume 182, Issue 22, Page 5453-5468, November 2025.
Background and Purpose Hydrogen sulphide (H2S) is synthesised endogenously through cystathionine β‐synthase (CBS), cystathionine γ‐lyase (CSE) and 3‐mercaptopyruvate sulfurtransferase (3‐MST). Although exogenous H2S is known to produce vasodilatation, the vascular effect of H2S produced through 3‐MST is unknown. In this study, we demonstrate the effect
Maha Almaheize, Sahar Alharthi, Patricia Hemp, Jennifer Mattos, Marcus van Leer, Michael Garle, Stephen Alexander, Richard Roberts   +7 more
wiley   +1 more source

L'Élucidation de la Signalisation du Sulfure d'Hydrogène par Persulfidation

, 2019
Hydrogen sulfide (H2S), originally considered a toxic gas, is now a recognised gasotransmitter. Numerous studies have revealed the role of H2S as a redox signalling molecule that controls important physiological/pathophysiological functions.
Kouroussis, Emilia
core   +1 more source

Alfalfa Transcription Factor MsNAC2a Orchestrates the Homeostasis of Salt Stress Responses via Reactive Oxygen Species Accumulation and Hydrogen Sulphide Depletion

Plant Biotechnology Journal, Volume 23, Issue 11, Page 5297-5320, November 2025.
ABSTRACT Soil salinisation poses a significant threat to alfalfa (Medicago sativa L.) growth and development, limiting its productivity and hindering its widespread cultivation. Hydrogen sulphide (H2S) serves as an important gaseous signalling molecule in plants, mediating a myriad of physiological processes like salt tolerance.
Songchong Lu, Yan Sun, Zhaozi Wang, Wanting Yu, Ziyi Dong, Shikai Li, Lichao Ma, Kunlong Su, Huajie Zhang, Zeng‐Yu Wang, Juan Sun, Sheng Luan, Guofeng Yang   +12 more
wiley   +1 more source

H₂S Donor Therapy Reverses Established Pulmonary Arterial Hypertension and Pulmonary Vascular Structural Remodeling in Rats

Biomedicines
Objectives: Downregulation of the endogenous gasotransmitter hydrogen sulfide (H2S) contributes to the pathogenesis of pulmonary arterial hypertension (PAH).
Jie Zheng, Yanan Zhang, Boyang Lv, Yuanyuan Ma, Xuecong Zhong, Junbao Du, Hongfang Jin, Yaqian Huang   +7 more
doaj   +1 more source

Cardiac Arrest After Inhalation of Hazardous Gas Suspected Hydrogen Sulfide at Cucumber Pickle Factory: Two Case Reports

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT We report two cases of acute occupational exposure to hazardous gas, suspected to be hydrogen sulfide. The 34‐year‐old male and 48‐year‐old female patients worked as cleaners at a pickled cucumber factory. The two victims cleaned a waste tank (containing organic waste that can produce hydrogen sulfide) that had been abandoned for 2 years, with
Thi Bich Van Ha, Duc Lich Nguyen, Tat Luat Bui, Dinh Thanh Son Le, Na Le, Ngoc Anh Tran, Hong Thai Phan   +6 more
wiley   +1 more source

CSE/H2S/SESN2 Signalling Mediates the Protective Effect of Exercise Against Immobilization‐Induced Muscle Atrophy in Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Hydrogen sulphide (H2S), a gasotransmitter synthesized by cystathionine‐γ‐lyase (CSE), exhibits antioxidant properties and may mimic exercise‐induced muscle protection. However, its mechanistic role in muscle atrophy and exercise intervention remains unclear.
Xiuru Li, Yating Huang, Xuege Yang, Sujuan Liu, Yanmei Niu, Li Fu   +5 more
wiley   +1 more source