Results 91 to 100 of about 4,338 (207)

Mining proteomes for zinc finger persulfidation

RSC Chemical Biology
A meta-analysis of 22 persulfide-specific proteomics datasets reveals widespread persulfidation of zinc finger proteins across various species, highlighting the role of persulfidation as an important post-translational modification.
Haoju Li, Andrew T. Stoltzfus, Sarah L. J. Michel   +2 more
openaire   +2 more sources

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Redox Modulation at Work: Natural Phytoprotective Polysulfanes From Alliums Based on Redox-Active Sulfur [PDF]

, 2018
Purpose of review: This article provides a brief overview of natural phytoprotective products of allium with a special focus on the therapeutic potential of diallyl polysulfanes from garlic, their molecular targets and their fate in the living organisms.
A Anwar, A Anwar, A Anwar, A Arunkumar, A Das, A Muller, AA Powolny, BA Iwalokun, BC Lee, C Chen, C Jacob, C Oosthuizen, CD Fisher, CJ Cavallito, CS Yang, D Liang, D Wallock-Richards, D Xiao, DM Davenport, DR Allah, E Germain, EA O'Gara, EA O'Gara, F Aala, F Zhang, G Ferrer-Sueta, G Filomeni, G Li, G Li, GA Benavides, GC Wallace, H Fujisawa, H Jurkowska, H Nakagawa, H Nian, H Tsuchiya, HC Wang, HT Hassan, I Gull, I Gull, J Antosiewicz, J Taucher, Jana Reiter, JM Bradley, K Chandra-Kuntal, KC Lai, KL Liu, L Cellini, L Masip, L Yi, LD Lawson, M Abouelfetouh, M Iciek, M Zardast, Małgorzata Iciek, MB Iciek, MC Gruhlke, Michael Puccinelli, MM Fani, MW Ha, N Druesne, NEB Saidu, NEB Saidu, P Gong, P Mikaili, P Rattanachaikunsopon, Qing Liu, RR Cutler, S Ankri, S Kim, S Shetty, SD Stan, SK Saha, T Hosono, T Schneider, T Seki, Toyohiko Ariga, U Münchberg, VA Kiesel, WR Li, X-y Lei, XY Jiang, Y Liu, Y Shadkchan, YA Kim, YR Cai, Z Shigemi, Z Wang, ZM Ross   +88 more
core   +1 more source

Biosynthesis and Reactivity of Cysteine Persulfides in Signaling [PDF]

Journal of the American Chemical Society, 2015
Hydrogen sulfide (H2S) elicits pleiotropic physiological effects ranging from modulation of cardiovascular to CNS functions. A dominant method for transmission of sulfide-based signals is via posttranslational modification of reactive cysteine thiols to persulfides. However, the source of the persulfide donor and whether its relationship to H2S is as a
Pramod K, Yadav, Michael, Martinov, Victor, Vitvitsky, Javier, Seravalli, Rudolf, Wedmann, Milos R, Filipovic, Ruma, Banerjee   +6 more
openaire   +2 more sources

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, Volume 183, Issue 1, Page 115-130, January 2026.
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Regulation, sensory domains and roles of two Desulfovibrio desulfuricans ATCC27774 Crp family transcription factors, HcpR1 and HcpR2, in response to nitrosative stress [PDF]

, 2016
In silico analyses identified a Crp/Fnr family transcription factor (HcpR) in sulfate-reducing bacteria that controls expression of the hcp gene, which encodes the hybrid cluster protein and contributes to nitrosative stress responses.
Browning, D., Busby, S.J., Cadby, I.T., Cole, J.A., Faulkner, M., Green, J., Ibrahim, S.A., Lee, D.J., Lovering, A.L., Stapleton, M.R.   +9 more
core   +2 more sources

Substitutions in the redox-sensing PAS domain of the NifL regulatory protein define an inter-subunit pathway for redox signal transmission [PDF]

, 2011
The Per-ARNT-Sim (PAS) domain is a conserved a/ß fold present within a plethora of signalling proteins from all kingdoms of life. PAS domains are often dimeric and act as versatile sensory and interaction modules to propagate environmental signals to ...
Ayers, Campbell, Demeler, Dixon, Hefti, Hill, Karimova, Key, Kurokawa, Little, Little, Little, Ma, Macheroux, Martinez-Argudo, Matthews, Miyatake, Money, Möglich, Möglich, Möglich, Nan, Perry, Qi, Reyes-Ramirez, Reyes-Ramirez, Slavny, Söderbäck, Taylor, Ukaegbu, Watts, Williamson, Zhou, Zoltowski, Zoltowski   +34 more
core   +1 more source

H2S Is a Potential Universal Reducing Agent for Prx6‐Type Peroxiredoxins

Advanced Science, Volume 12, Issue 46, December 11, 2025.
We report the identification of H2S as reducing agent for Prx6‐type peroxiredoxins. In contrast to common physiological reducing agents of other peroxiredoxins, HS− is small enough to access the active site of oxidized Prx6‐type enzymes in the fully‐folded protein conformation.
Lukas Lang, Laura Leiskau, Lea Bambach, Marcel Deponte   +3 more
wiley   +1 more source

Sulfide-Responsive Transcription Control in Escherichia coli

Microorganisms
To elucidate the mechanism of large-scale transcriptional changes dependent on sulfide in Escherichia coli, a large-scale RNA-sequencing analysis was performed on wild-type and sulfide-responsive transcription factor YgaV deletion mutants grown under ...
Koichi Hori, Rajalakshmi Balasubramanian, Shinji Masuda   +2 more
doaj   +1 more source

Biosynthesis of Sulfur-Containing tRNA Modifications: A Comparison of Bacterial, Archaeal, and Eukaryotic Pathways

Biomolecules, 2017
Post-translational tRNA modifications have very broad diversity and are present in all domains of life. They are important for proper tRNA functions.
Mirela Čavužić, Yuchen Liu
doaj   +1 more source