Results 101 to 110 of about 3,419 (230)

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, Volume 183, Issue 1, Page 115-130, January 2026.
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Sulfide-Responsive Transcription Control in Escherichia coli

Microorganisms
To elucidate the mechanism of large-scale transcriptional changes dependent on sulfide in Escherichia coli, a large-scale RNA-sequencing analysis was performed on wild-type and sulfide-responsive transcription factor YgaV deletion mutants grown under ...
Koichi Hori, Rajalakshmi Balasubramanian, Shinji Masuda   +2 more
doaj   +1 more source

Biosynthesis of Sulfur-Containing tRNA Modifications: A Comparison of Bacterial, Archaeal, and Eukaryotic Pathways

Biomolecules, 2017
Post-translational tRNA modifications have very broad diversity and are present in all domains of life. They are important for proper tRNA functions.
Mirela Čavužić, Yuchen Liu
doaj   +1 more source

Staphylococcus aureus CstB Is a Novel Multidomain Persulfide Dioxygenase-Sulfurtransferase Involved in Hydrogen Sulfide Detoxification

, 2015
Hydrogen sulfide (H2S) is both a lethal gas and an emerging gasotransmitter in humans, suggesting that the cellular H2S level must be tightly regulated. CstB is encoded by the cst operon of the major human pathogen Staphylococcus aureus and is under the ...
David P. Giedroc (1560214), Richard N. Armstrong (583761), Jiangchuan Shen (1560208), Katherine A. Edmonds (1560205), Khadine A. Higgins (1560211), Mary E. Keithly (1306419)   +5 more
core   +1 more source

H2S Is a Potential Universal Reducing Agent for Prx6‐Type Peroxiredoxins

Advanced Science, Volume 12, Issue 46, December 11, 2025.
We report the identification of H2S as reducing agent for Prx6‐type peroxiredoxins. In contrast to common physiological reducing agents of other peroxiredoxins, HS− is small enough to access the active site of oxidized Prx6‐type enzymes in the fully‐folded protein conformation.
Lukas Lang, Laura Leiskau, Lea Bambach, Marcel Deponte   +3 more
wiley   +1 more source

Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single‐cell resolution

iMeta, Volume 4, Issue 6, December 2025.
Single‐cell and transcriptomics from 1.79 million cells identify the forestomach epithelium as the dominant site of antioxidant activity and oxidative phosphorylation (OXPHOS) in the bovine gastrointestinal tract. Along the basal‐to‐luminal differentiation axis, antioxidant capacity and OXPHOS rise in a coordinated metabolic–redox gradient.
Sen‐Lin Zhu, Yu‐Nan Yan, Ming‐Hui Jia, Hou‐Cheng Li, Bo Han, Tao Shi, Lian‐Bin Xu, Xiao‐Wen Wang, Qi Zhang, Wei‐Jie Zheng, Jing‐Hong Xu, Liang Chen, Wenlingli Qi, Sheng‐Jun Cai, Xin‐Peng Chen, Feng‐Fei Gu, Jian‐Xin Liu, George E. Liu, Yu Jiang, Dong‐Xiao Sun, Ling‐Zhao Fang, Hui‐Zeng Sun   +21 more
wiley   +1 more source

Development of an anti-oxidative intraocular irrigating solution based on reactive persulfides [PDF]

, 2022
Hiroshi Kunikata, Hiroshi Tawarayama, Satoru Tsuda, Takaaki Akaike, Toru Nakazawa   +4 more
openalex   +1 more source

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

, 2019
Life on Earth emerged in a hydrogen sulfide (H2S)-rich environment eons ago and with it protein persulfidation mediated by H2S evolved as a signaling mechanism.
Kohl, Joshua B., Filipović, Miloš R., Milošević, Verica, Mitchell, James R., Adhikari, Bikash, Benhar, Moran, Gonzales-Zorn, Bruno, Carroll, Kate S., Ivanović-Burmazović, Ivana, Jung, Youngeun, Schott-Roux, Sonia, Gomes, Jose Eduardo, Paul, Bindu D., Miler, Marko, Bursać, Biljana, Torregrossa, Roberta, Snyder, Solomon H., Kouroussis, Emilia, Whiteman, Matthew, Miljković, Jan Lj., Gonzalez-Zorn, Bruno, Živanović, Jasmina, Petrović, Dunja, Thomas-Lopez, Daniel, Schwarz, Guenter, Mitchell, Sarah   +25 more
core   +2 more sources

Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation [PDF]

, 2023
Shunichi Tayama, Yuya Kitamura, Kyoga Hiraide, Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Yuko Okuyama, Takeshi Kawabe, Takaaki Akaike, Naoto Ishii   +10 more
openalex   +1 more source

Structural and Kinetic Characterization of Hyperthermophilic NADH-Dependent Persulfide Reductase from Archaeoglobus fulgidus [PDF]

, 2021
Sherwin Shabdar, Bukuru Anaclet, Ana Garcia Castineiras, Neyissa Desir, Nicholas Choe, Edward J. Crane, Matthew H. Sazinsky   +6 more
openalex   +1 more source