The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus [PDF]
, 2019 Aims: Quinone compounds are electron carriers and have antimicrobial and toxic properties due to their mode of actions as electrophiles and oxidants.
Fritsch, Verena Nadin +9 more
core +1 more source
iMeta, Volume 4, Issue 6, December 2025.Single‐cell and transcriptomics from 1.79 million cells identify the forestomach epithelium as the dominant site of antioxidant activity and oxidative phosphorylation (OXPHOS) in the bovine gastrointestinal tract. Along the basal‐to‐luminal differentiation axis, antioxidant capacity and OXPHOS rise in a coordinated metabolic–redox gradient.
Sen‐Lin Zhu +21 more
wiley +1 more source
Functional Characterization of the Eukaryotic Cysteine Desulfurase Nfs1p from Saccharomyces cerevisiae [PDF]
, 2004 Previous studies have indicated that the essential protein Nfs1 performs a crucial role in cellular iron-sulfur (Fe/S) protein maturation. The protein is located predominantly in mitochondria, yet low amounts are present in cytosol and nucleus.
Balk +73 more
core +3 more sources
ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism
ChemBioChem, Volume 26, Issue 21, November 8, 2025.ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler +2 more
wiley +1 more source
Hydrogen Sulfide: Redox Metabolism and Signaling [PDF]
, 2011 The recognition of hydrogen sulfide (H2S) as an endogenously produced gas with signaling potential has stimulated research on a multitude of physiological effects mediated in the cardiovascular, immune, gastrointestinal, genitourinary, endocrine, and ...
Banerjee, Ruma
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Hydrogen sulfide promotes lateral root formation in peach through persulfidation of SnRK1α kinase
Plant Biotechnology Journal, Volume 23, Issue 10, Page 4395-4411, October 2025.Summary Root development is crucial for the growth and yield of horticultural crops. Hydrogen sulfide (H2S), an important gasotransmitter, has been shown to regulate lateral root (LR) formation in plants, including peach (Prunus persica). However, its specific regulatory mechanism remains largely unclear.
Xuelian Wu +5 more
wiley +1 more source
The Role of Bacillithiol in Gram-Positive Firmicutes [PDF]
, 2018 Significance: Since the discovery and structural characterization of bacillithiol (BSH), the biochemical functions of BSH-biosynthesis enzymes (BshA/B/C) and BSH-dependent detoxification enzymes (FosB, Bst, GlxA/B) have been explored in Bacillus and ...
Antelmann, Haike +3 more
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A persulfidation-based mechanism controls aquaporin-8 conductance
Science Advances, 2018 A two-step posttranslational modification of AQP8 provides a mechanism regulating plasma membrane H 2 O 2 conductance.
Stefano Bestetti +8 more
openaire +4 more sources
Transcriptional regulation of bacterial virulence gene expression by molecular oxygen and nitric oxide [PDF]
, 2014 © Jeffrey Green, Matthew D Rolfe, and Laura J Smith. Molecular oxygen (O2) and nitric oxide (NO) are diatomic gases that play major roles in infection.
Green, J., Rolfe, M.D., Smith, L.J.
core +1 more source
Cytosolic Fe-S cluster protein maturation and iron regulation are independent of the mitochondrial Erv1/Mia40 import system [PDF]
, 2015 The sulfhydryl oxidase Erv1 partners with the oxidoreductase Mia40 to import cysteine-rich proteins in the mitochondrial intermembrane space. In Saccharomyces cerevisiae, Erv1 has also been implicated in cytosolic Fe-S protein maturation and iron ...
Adrienne C. Dlouhy +65 more
core +2 more sources